The association of night shift work with the risk of all-cause dementia and Alzheimer's disease: a longitudinal study of 245,570 UK Biobank participants

Ling, Yitong; Yuan, Shiqi; Huang, Xiaxuan; Tan, Shanyuan; Xu, Anding; Lyu, Jun

doi:10.1007/s00415-023-11672-8

Cited by 9 publications

(3 citation statements)

References 61 publications

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“…The UK Biobank is a substantial research cohort consisting of over 500 000 individuals enrolled in the United Kingdom between 2006 and 2010. These participants underwent baseline assessments, including physical, sociodemographic, and medical evaluations ( 20 , 21 ). Starting in 2014, the UK Biobank initiated magnetic resonance imaging (MRI), including brain imaging, with the goal of gathering imaging data from 100 000 participants.…”

Section: Methodsmentioning

confidence: 99%

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Ling,

Yuan,

Huang

et al. 2023

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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Previous researchers have tried to explore the association between folate/folic acid intake and dementia incidence, but the results remain controversial. We evaluated the associations of folate/folic acid supplementation alone and in combination with other B vitamins on dementia risk and brain structure. A total of 466,224 UK Biobank participants were investigated. Cox proportional hazards models were used to assess the associations between folate/folic acid supplementation status and the risk of Alzheimer's disease (AD) and vascular dementia (VD). Multivariable linear regression models were employed to evaluate the association between folate/folic acid supplementation status and brain structure. In the final model, folate/folic acid supplementation alone was significantly associated with a higher risk of AD (hazard ratio [HR] =1.34, 95% confidence interval [CI] =1.06 to 1.69, p=0.015) and VD (HR=1.61, 95% CI=1.21 to 2.13, p=0.001). Folate/folic acid supplementation alone was associated with a reduction in the hippocampus (β= -95.25 mm3, 95% CI= -165.31 to -25.19 mm3, p=0.014) and amygdala (β= -51.85 mm3, 95% CI= -88.02 to -15.68 mm3, p=0.012). The risk of AD and VD, as well as brain structure, in the group with combined folate/folic acid supplementation and other B vitamins did not show a statistically significant difference compared to the reference group (all p>0.05). Folate/folic acid supplementation alone is significantly associated with a higher risk of AD and VD, as well as adverse alterations in brain structure. However, when combined with other B vitamins, these detrimental effects can be counteracted.

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Section: Methodsmentioning

confidence: 99%

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Ling,

Yuan,

Huang

et al. 2023

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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show abstract

“…Moreover, long-term shift work was identified to be a significant risk factor for various serious disorders, such as mental disorders (Booker et al, 2020), dementia (Ling et al, 2023), endocrine disorders (Hansen et al, 2016), and cardiovascular diseases (Vetter et al, 2016), especially for the females.…”

Section: Introductionmentioning

confidence: 99%

“…A recent cross‐sectional study from China demonstrated that about 60% of shift nurses exhibited work‐related disorders, manifesting as a higher incidence of mental health problems, sleep disorders, and burnout (Cheng et al., 2023 ). Moreover, long‐term shift work was identified to be a significant risk factor for various serious disorders, such as mental disorders (Booker et al., 2020 ), dementia (Ling et al., 2023 ), endocrine disorders (Hansen et al., 2016 ), and cardiovascular diseases (Vetter et al., 2016 ), especially for the females.…”

Section: Introductionmentioning

confidence: 99%

Alterations of functional brain activity and connectivity in female nurses working on long‐term shift

Dong,

Wu,

Dong

et al. 2024

Nursing Open

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AimTo investigate the alterations of functional brain activity and connectivity in female nurses working on long‐term shifts and explore their correlations with work‐related psychological traits.DesignAn exploratory cross‐sectional study.MethodsThirty‐five female nurses working on long‐term shifts (shift nurses) and 35 female nurses working on fixed days (fixed nurses) were enrolled. After assessing the work‐related psychological traits, including burnout, perceived stress, anxiety, and depression of nurses, the fractional amplitude of low‐frequency fluctuations (fALFF) and region of interest (ROI)‐based functional connectivity (FC) analyses were performed to investigate the differences of brain spontaneous activity and functional connectivity between these two groups of nurses. Thereafter, correlations between the functional brain parameters (fALFF and FC) and clinical metrics were investigated among the shift nurses.ResultsCompared to fixed nurses, shift nurses had higher burnout, perceived stress and depression scores, lower fALFF in the right dorsolateral prefrontal cortex (dlPFC), left and right superior parietal lobule (SPL), bilateral anterior cingulate cortex (ACC), and higher fALFF in the right superior/middle temporal gyrus, as well as decreased FC between the right dlPFC (the selected ROI) and bilateral ACC, left and right inferior frontal/orbitofrontal gyrus (IFG/IOFG), right SPL, and left middle occipital gyrus (voxel‐level p < 0.001, cluster level p < 0.05, GRF correction). Correlation analyses demonstrated that the fALFF value of the right dlPFC was significantly correlated with the burnout and anxiety scores, the FC value of the right dlPFC‐right SPL was correlated with the perceived stress and burnout scores, the FC value of the right dlPFC‐right IFG/IOFG was correlated with the burnout score in shift nurses (p < 0.05).ConclusionShift nurses had work‐related altered functional activity and connectivity in the right frontoparietal network, which provided objective and visualised evidence to clarify the hazards of long‐term shift work on female nurses.Patient or Public ContributionSeventy nurses participated deeply as subjects in this study. These findings are expected to draw managers' attention to the harmful influences of shift work on nurses.

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Association of sleep duration with excess risk of dementia among shift workers in the UK biobank: a population-based cohort study

Chang,

Liu,

Zhao

et al. 2024

J Neurol

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The association of night shift work with the risk of all-cause dementia and Alzheimer's disease: a longitudinal study of 245,570 UK Biobank participants

Cited by 9 publications

References 61 publications

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Alterations of functional brain activity and connectivity in female nurses working on long‐term shift

Association of sleep duration with excess risk of dementia among shift workers in the UK biobank: a population-based cohort study

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