The association of non-invasive skin autofluorescence measurements with cardiovascular and all-cause mortality in hemodialysis patients: a meta-analysis

Varikasuvu, Seshadri Reddy; Sulekar, Harish; Aloori, Sowjanya; Thangappazham, Balachandar

doi:10.1007/s11255-020-02543-6

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…A previous study from our group reported an association between SAF and all-cause mortality in the general population [10]. Other studies on mortality have been performed in speci c groups of patients, and have reported an association between SAF and cardiovascular mortality in patients with chronic kidney disease [18], chronic hemodialysis [11,[19][20][21], type 1 and type 2 diabetes [13], and peripheral artery disease [12]. The present study extends our earlier observations because we were able to link overall mortality data with speci c causes of death, which are registered at the o cial death certi cates.…”

Section: Discussionmentioning

confidence: 93%

Skin autofluorescence and cause-specific mortality: from a population-based cohort

Boersma,

Smit,

Paterson

et al. 2024

Preprint

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We aimed to assess the association of SAF with cardiovascular mortality in the general population and the possible association between SAF with other disease-specific mortality rates. We evaluated 77,143 participants without known diabetes or cardiovascular disease. The cause of death was ascertained by the municipality database. The associations between SAF and all-cause mortality, cardiovascular mortality and cancer mortality were assessed with Cox proportional hazard analysis.After a median follow-up of 115 months, 1447 participants were deceased (1.9%). SAF and age-adjusted SAF-z score were higher in all mortality groups. Cox regression analysis revealed that the highest quartile of SAF was associated with increased odds of cardiovascular mortality, (HR) 12.6 (7.3–21.7) and after adjusting for age (HR 1.8 (1.0-3.2)). Significance was lost after additional adjustments for sex, smoking status, and BMI (HR 1.4 (0.8–2.5). For cancer-related mortality the highest quartile of SAF was associated with higher probability of mortality in all models (unadjusted HR 8.6 (6.6–11.3), adjusted for age HR 2.1 (1.6–2.8)), adjusted for age, sex, smoking status, and BMI HR 1.7 (1.3–2.4)). SAF is associated with all-cause mortality as well as cardiovascular and cancer-related mortality in the general population.

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Section: Discussionmentioning

confidence: 93%

Skin autofluorescence and cause-specific mortality: from a population-based cohort

Boersma,

Smit,

Paterson

et al. 2024

Preprint

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“…As a result, endothelial dysfunction, vasoconstriction, fibrosis, atherosclerosis, and thrombosis would develop. [ 53 ] Nowadays, HbA1c with shorter turnover represents a chronic hyperglycemic state. Besides, in addition to hyperglycemia, the AGE level could also be a potential marker of metabolic load and a surrogate marker of DM or diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case–control studies

Hosseini,

Razavi,

Bahri

et al. 2023

Journal of Research in Medical Sciences

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Background: The advanced glycation end product (AGE) is produced from the nonenzymatic reaction between glucose and macromolecules by aging. Accumulation of AGE causes functional and structural changes in body proteins that lead to impairment of tissue protein functions. We aimed to validate AGE measurement by skin autofluorescence (SAF) in diabetes mellitus (DM) compared to the nondiabetes population. Materials and Methods: We searched the PubMed, Cochrane, and Scopus databases from their inception till September 18, 2022, for casecontrol studies measuring AGE by SAF. Nonhuman studies, as well as review articles, study proposals, editorials, case reports, or congress posters, were excluded. We used a random effects model to assess the standard mean difference (MD) of age, body mass index (BMI), HbA1c, and SAF between diabetes and nondiabetes individuals. Results: Higher SAF in DM patients indicated more accumulation of AGE compared with the nondiabetic population. Furthermore, HbA1c was considerably higher in DM patients. The MD of age, male gender, and BMI were significantly different between the DM individuals, compared with nondiabetic subjects, which can lead to altered SAF level and AGE production. There was a remarkable heterogeneity between diabetes and nondiabetes when measuring age, gender, and BMI, as well as HbA1c and SAF level. Conclusion: This study could not confirm the validity of SAF as a surrogate marker in diabetes patients. Interestingly, metabolic load and high BMI can increase SAF, considerably. Altogether, SAF could be helpful in the future as a marker for metabolic syndrome or diabetes.

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“…Numerous pathological mechanisms for AGE that can cause D-MVE and even mortality are introduced. They consequently result in endothelial dysfunction, arterial stiffness, vasoconstriction, proliferation and thickness of vessel wall, atherosclerotic plaque progression, thrombosis, and fibrosis [49,50]. Although max-IMT is a powerful marker for atherosclerosis and predicting cardiovascular events, the results of previous studies regarding the association of SAF and max-IMT were inconsistent [11,28].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of non-invasive skin autofluorescence measurement in patients with diabetes: a systematic review and meta-analysis

et al. 2021

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The association of non-invasive skin autofluorescence measurements with cardiovascular and all-cause mortality in hemodialysis patients: a meta-analysis

Cited by 8 publications

References 49 publications

Skin autofluorescence and cause-specific mortality: from a population-based cohort

Skin autofluorescence and cause-specific mortality: from a population-based cohort

Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case–control studies

Clinical significance of non-invasive skin autofluorescence measurement in patients with diabetes: a systematic review and meta-analysis

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