The association of opioid consumption and osteoporosis in old men: Bushehr Elderly Health (BEH) program

Sanjari, Mahnaz; Yarmohammadi, Hossein; Fahimfar, Noushin; Gharibzadeh, Safoora; Khalagi, Kazem; Shafiee, Gita; Heshmat, Ramin; Nabipour, Iraj; Amini, Azam; Darabi, Amirhossein; Ghazbani, Arash; Larijani, Bagher; Ostovar, Afshin

doi:10.1007/s11657-022-01181-y

Cited by 2 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study of older adults by Marques et al [ 38 ] showed that, after the confounding variables were moderated, current and previous smoking harmed the health of bones and current smoking in particular can aggravate loss of bone density in older ages. As for drug abuse, most studies have indicated a correlation between opioids and osteoporosis [ 21 – 23 , 39 ]. In general, the discrepancy between the findings of the present study and the above studies can be explained, by smoking, some of the older adults might have refused to mention that they smoked.…”

Section: Discussionmentioning

confidence: 99%

“…A study by Ahmadi et al (2022) reported that 11.3% of the older adults in Tehran abused substances: 3.74% and 83.20% were addicted to opium and alcohol respectively [ 20 ]. Some studies show that opium with inhibiting Gonadotropin-releasing hormone (GnRH) and the ability of Inhibition of osteoblasts؛ may be associated with increased risk of osteoporosis [ 21 ]. Gozashti et al and Li et al indicated that opium addicts are more vulnerable to the occurrence of BMD loss compared with non-addicts [ 22 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Smoking, alcohol consumption, drug abuse, and osteoporosis among older adults: a cross-sectional study on PERSIAN cohort study in Fasa

Khiyali,

Rashedi,

Tavacol

et al. 2024

BMC Geriatr

View full text Add to dashboard Cite

Background With increasing life expectancy and a growing population of older adults, the prevalence of osteoporosis has risen, resulting in a higher incidence of bone fractures, which necessitate extended treatment and specialized medical care. This study investigates the relationship between smoking, alcohol consumption, drug abuse, and osteoporosis among older adults in southern Iran, utilizing cohort data. Methods This cross–sectional study is derived from the Fasa Adult Cohort Study (FACS), which included 10,133 individuals. From this cohort, we selected 1,631 older adults using census sampling methods. Our study aimed to explore the correlation between smoking, alcohol consumption, and drug abuse among older adults and the incidence of osteoporosis. We collected demographic information, nutritional indexes, medical history, glucocorticoid usage, and self-reported data on smoking, alcohol consumption, drug abuse, and osteoporosis through questionnaires. To investigate the relationship between smoking, alcohol, and drug use with osteoporosis while accounting for confounding factors, we employed logistic regression analysis. Results The average age of the study participants was 64.09 ± 3.8 years, with a majority (898 (55.1%)) being female. Osteoporosis prevalence among the subjects was 25.20%. The results did not reveal a significant correlation between smoking, alcohol consumption, drug abuse, and osteoporosis (p > 0.05). Regression analysis identified gender, recent history of fractures within the past five years, history of using glucocorticoids, and physical activity as significant predictive risk factors for osteoporosis within the study population (p < 0.05). Conclusion The study underscores the significance of addressing osteoporosis risk factors in older adults. Healthcare policymakers and administrators can use these findings to identify and mitigate influential factors contributing to osteoporosis in this demographic.

show abstract

Section: Discussionmentioning

confidence: 99%