The Association of Oral Microbiome Dysbiosis with Gastrointestinal Cancers and Its Diagnostic Efficacy

Asili, Pooria; Mirahmad, Maryam; Rezaei, Parisa; Mahdavi, Mohammad; Larijani, Bagher; Tavangar, Seyed Mohammad

doi:10.1007/s12029-022-00901-4

Cited by 5 publications

(2 citation statements)

References 127 publications

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“…We also found Veillonellaceae, Prevotella, Oribacterium were associated with pancreatic cancer. Veillonellaceae F0422 belongs to the phyla Firmicutes, a common oral microbiome that may be related to gastrointestinal cancers (Asili et al, 2023). Research has indicated a correlation between Prevotella bacteria presence and symptoms of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis

Feng,

Ren,

Wang

2023

Front. Mol. Biosci.

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Background: The oral microbiome has been intricately linked to various pathological conditions, notably cancer, though clear causal links remain elusive. This study aimed to investigate the potential causal relationships between the oral microbiome and seven major cancers: breast, lung, pancreatic, colorectal, gastric, ovarian, and prostate cancers, leveraging Mendelian randomization (MR).Methods: A two-sample MR analysis was conducted using genome-wide association study (GWAS) data specific to oral microbiota in individuals of East Asian descent. Single nucleotide polymorphisms (SNPs) independent of confounders served as instrumental variables (IVs) to deduce causality. MR methodologies such as the inverse variance weighted (IVW) method, weighted median (WM) method, and Mendelian randomization-Egger (MR-Egger) method were employed. The study utilized datasets encapsulating a multitude of cancer cases and controls, focusing on Asian populations.Results: Our analysis revealed intricate associations between specific bacterial genera of the oral microbiome and diverse cancers. Notably, Fusobacterium showed mixed associations with various cancers, while genera like Prevotella and Streptococcus exhibited nuanced roles across malignancies. The genus Aggregatibacter demonstrated a multifaceted influence, positively correlating with some cancers while inhibiting others.Conclusion: Our findings underscore the profound implications of the oral microbiome in systemic malignancies, suggesting potential modulatory roles in cancer etiology. These insights, though preliminary, accentuate the need for deeper exploration and could pave the way for novel therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis

Feng,

Ren,

Wang

2023

Front. Mol. Biosci.

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“…The SHH-BMP4 signaling axis, which is involved in BE, is also upregulated upon C. concisus infection. Interestingly, C. concisus infection can upregulate the SOX5 and TWIST1 genes, which contribute to EMT [ 31 , 99 ]. This potential similarity to the role of H. pylori in gastric cancer highlights the emerging recognition of Campylobacter as a human pathogen [ 100 ].…”

Section: Mechanisms Of Microbiome Impact On Esophageal and Gastric Ca...mentioning

confidence: 99%

The Influence of the Microbiome on Immunotherapy for Gastroesophageal Cancer

Dadgar,

Edlukudige Keshava,

Raj

et al. 2023

Cancers

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Immunotherapy has shown promise as a treatment option for gastroesophageal cancer, but its effectiveness is limited in many patients due to the immunosuppressive tumor microenvironment (TME) commonly found in gastrointestinal tumors. This paper explores the impact of the microbiome on the TME and immunotherapy outcomes in gastroesophageal cancer. The microbiome, comprising microorganisms within the gastrointestinal tract, as well as within malignant tissue, plays a crucial role in modulating immune responses and tumor development. Dysbiosis and reduced microbial diversity are associated with poor response rates and treatment resistance, while specific microbial profiles correlate with improved outcomes. Understanding the complex interactions between the microbiome, tumor biology, and immunotherapy is crucial for developing targeted interventions. Microbiome-based biomarkers may enable personalized treatment approaches and prediction of patient response. Interventions targeting the microbiome, such as microbiota-based therapeutics and dietary modifications, offer the potential for reshaping the gut microbiota and creating a favorable TME that enhances immunotherapy efficacy. Further research is needed to reveal the underlying mechanisms, and large-scale clinical trials will be required to validate the efficacy of microbiome-targeted interventions.

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Relationship between oral microbiota and colorectal cancer: A systematic review

Camañes‐Gonzalvo,

Montiel‐Company,

Lobo‐de‐Mena

et al. 2024

J of Periodontal Research

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This systematic review aims to investigate the microbial basis underlying the association between oral microbiota and colorectal cancer. A comprehensive search was conducted across four databases, encompassing potentially relevant studies published up to April 2024 related to the PECO question: “Is there a differentiation in oral microbial composition between adult patients diagnosed with colorectal cancer compared to healthy patients?”. The Newcastle‐Ottawa Scale was used to evaluate the quality of the studies included. The level of evidence was assessed through the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) tool. Sixteen studies fulfilled the eligibility criteria. Based on low to moderate evidence profile, high levels of certain subspecies within Firmicutes (such as Streptococcus anginosus, Peptostreptococcus stomatis, S. koreensis, and S. gallolyticus), Prevotella intermedia, Fusobacterium nucleatum, and Neisseria oralis were found to be associated with colorectal cancer. Conversely, certain bacteria (e.g., Lachnospiraceae, F. periodonticum, and P. melaninogenica) could exert a symbiotic protective effect against colorectal cancer. Based on existing evidence, it appears that variations in oral microbiota composition exist among individuals with and without colorectal cancer. However, further research is necessary to determine the mechanisms of oral dysbiosis in colorectal carcinogenesis.

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The Association of Oral Microbiome Dysbiosis with Gastrointestinal Cancers and Its Diagnostic Efficacy

Cited by 5 publications

References 127 publications

Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis

Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis

The Influence of the Microbiome on Immunotherapy for Gastroesophageal Cancer

Relationship between oral microbiota and colorectal cancer: A systematic review

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