The association of osteochemometrics and bone mineral density in humans

Pedrosa, Mariana; Ferreira, Maria Teresa; Carvalho, Luís A. E. Batista de; Marques, M. P. M.; Curate, Francisco

doi:10.1002/ajpa.24283

Cited by 5 publications

(3 citation statements)

References 94 publications

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“…Considering the 1400-1550 cm −1 region, a synthetic sample of the AB-type showed a single band at 1460 cm −1 that accounted for the contribution of two overlapped signals: the low-frequency ν a band of the A doublet and the high-frequency ν a band of the B doublet; the other ν a bands revealed a shift in the wavenumbers compared to the pure B and A standards [64]. Similar assignation was considered by Pedrosa et al for the bands of male and female femoral bone hydroxyapatite: the band at 1450 cm −1 is assigned to the type A + B carbonate, while the B type is recognized by the 1415 cm −1 band [66]. In some spectra of biological apatite, the above-mentioned band at 1460 cm −1 is observed as two signals: a band at 1450 and a shoulder at 1465 cm −1 [56].…”

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 72%

Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample

et al. 2022

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Although multiple structural, mechanical, and molecular factors are definitely involved in osteoporosis, the assessment of subregional bone mineral density remains the most commonly used diagnostic index. In this study, we characterized bone quality in the femoral neck of one osteoporotic patients as compared to an age-matched control subject, and so used a multiscale and multimodal approach including X-ray computed microtomography at different spatial resolutions (pixel size: 51.0, 4.95 and 0.9 µm), microindentation and Fourier transform infrared spectroscopy. Our results showed abnormalities in the osteocytes lacunae volume (358.08 ± 165.00 for the osteoporotic sample vs. 287.10 ± 160.00 for the control), whereas a statistical difference was found neither for shape nor for density. The osteoporotic femoral head and great trochanter reported reduced elastic modulus (Es) and hardness (H) compared to the control reference (−48% (p < 0.0001) and −34% (p < 0.0001), respectively for Es and H in the femoral head and −29% (p < 0.01) and −22% (p < 0.05), respectively for Es and H in the great trochanter), whereas the corresponding values in the femoral neck were in the same range. The spectral analysis could distinguish neither subregional differences in the osteoporotic sample nor between the osteoporotic and healthy samples. Although, infrared spectroscopic measurements were comparable among subregions, and so regardless of the bone osteoporotic status, the trabecular mechanical properties were comparable only in the femoral neck. These results illustrate that bone remodeling in osteoporosis is a non-uniform process with different rates in different bone anatomical regions, hence showing the interest of a clear analysis of the bone microarchitecture in the case of patients’ osteoporotic evaluation.

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Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 72%

Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample

et al. 2022

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“…4 C). The inclusion of cyanamide anion (NCN 2− ) within the bone´s framework, identified through its infrared peaks at 702 and 2017 cm −1 (respectively from NCN deformation and stretching modes), was previously only reported in bone heated at 650 °C and above under anaerobic conditions 14 , 19 . These observations lead us to conclude that the oxygen availability during heating differed for these archaeological skeletal remains: the fibula was burned in a more confined and anaerobic environment, leading to the absence of hydroxyapatite´s OH librational band and to the appearance of cyanamide.…”

Section: Resultsmentioning

confidence: 99%

Vibrational spectroscopy to study ancient Roman funerary practices at the “Hypogeum of the Garlands” (Italy)

Festa

Rubini

Zaio³

et al. 2022

Sci Rep

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The “Hypogeum of the Garlands” is a sepulchral site, recently found in Grottaferrata (Lazio, Italy), dating back to the first-second century AD. Two sarcophagi were discovered inside, hosting the human remains of Aebutia Quarta, a rich Roman woman, and her son Carvilius Gemellus. While the body of Carvilius is exceptionally well-preserved, following its embalming and perfect sealing of the sarcophagus, in the case of Aebutia only the bones were preserved because of the sarcophagus’s seal breaking down, although she was covered with perfectly preserved flower garlands. Embalming of the body was a rare ritual in the Imperial Roman times when corpses were more often cremated. The remains of Aebutia showed possible traces of heating. Burned bones from a third individual were discovered on the chamber’s floor and preliminary anthropological survey showed that this individual was a male of 40–50 years old. Here, a combination of spectroscopic techniques, including non-destructive inelastic neutron scattering and Raman spectroscopy, and minimally destructive Fourier transform infrared spectroscopy, were applied to the analysis of these bone samples to give information about ancient Roman funerary practices. The temperature and burning conditions were thus determined, showing that Aebutia Quarta was exposed to mild temperatures (200 °C) only in the upper part of the body, while the third individual was likely cremated as its bones were exposed to temperatures up to 900 °C in quasi-anaerobic conditions.

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“…ECM contains a small number of type I collagen fibres, which is the organic part of ECM. The rest of the ECM contains inorganic matter from the mineral phase, mostly comprising hydroxyapatites [1,2]. Primary cells Gels 2023, 9, 923 2 of 23 in bone tissues (osteoblasts, osteocytes and osteoclasts) actively communicate with each other to heal defects and facilitate bone growth, maintenance and resorption [3].…”

Section: Introductionmentioning

confidence: 99%

Metal Organic Framework-Incorporated Three-Dimensional (3D) Bio-Printable Hydrogels to Facilitate Bone Repair: Preparation and In Vitro Bioactivity Analysis

Choi,

Chakraborty,

Adzija

et al. 2023

Gels

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Hydrogels are three-dimensional (3D) water-swellable polymeric matrices that are used extensively in tissue engineering and drug delivery. Hydrogels can be conformed into any desirable shape using 3D bio-printing, making them suitable for personalized treatment. Among the different 3D bio-printing techniques, digital light processing (DLP)-based printing offers the advantage of quickly fabricating high resolution structures, reducing the chances of cell damage during the printing process. Here, we have used DLP to 3D bio-print biocompatible gelatin methacrylate (GelMA) scaffolds intended for bone repair. GelMA is biocompatible, biodegradable, has integrin binding motifs that promote cell adhesion, and can be crosslinked easily to form hydrogels. However, GelMA on its own is incapable of promoting bone repair and must be supplemented with pharmaceutical molecules or growth factors, which can be toxic or expensive. To overcome this limitation, we introduced zinc-based metal-organic framework (MOF) nanoparticles into GelMA that can promote osteogenic differentiation, providing safer and more affordable alternatives to traditional methods. Incorporation of this nanoparticle into GelMA hydrogel has demonstrated significant improvement across multiple aspects, including bio-printability, and favorable mechanical properties (showing a significant increase in the compressive modulus from 52.14 ± 19.42 kPa to 128.13 ± 19.46 kPa with the addition of ZIF-8 nanoparticles). The designed nanocomposite hydrogels can also sustain drug (vancomycin) release (maximum 87.52 ± 1.6% cumulative amount) and exhibit a remarkable ability to differentiate human adipose-derived mesenchymal stem cells toward the osteogenic lineage. Furthermore, the formulated MOF-integrated nanocomposite hydrogel offers the unique capability to coat metallic implants intended for bone healing. Overall, the remarkable printability and coating ability displayed by the nanocomposite hydrogel presents itself as a promising candidate for drug delivery, cell delivery and bone tissue engineering applications.

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The association of osteochemometrics and bone mineral density in humans

Cited by 5 publications

References 94 publications

Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample

Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample

Vibrational spectroscopy to study ancient Roman funerary practices at the “Hypogeum of the Garlands” (Italy)

Metal Organic Framework-Incorporated Three-Dimensional (3D) Bio-Printable Hydrogels to Facilitate Bone Repair: Preparation and In Vitro Bioactivity Analysis

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