The association of plasma IGF-I with dietary, lifestyle, anthropometric, and early life factors in postmenopausal women

Bradbury, Kathryn E.; Balkwill, Angela; Tipper, Sarah; Crowe, Francesca L.; Reeves, Gillian; Green, Jane; Beral, Valerie; Key, Timothy J.

doi:10.1016/j.ghir.2015.01.001

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…Our data suggest the potential role of IGF system in TDLU involution of the normal breast among both Caucasian and AA women. Consistent with findings from previous studies, 11,20,21,[36][37][38][39] our data demonstrated that several breast cancer risk factors may be associated with circulating levels of IGF-I and IGFBP-3. As expected, [37][38][39][40][41] age was inversely associated with circulating levels of IGF-I, IGFBP-3 and IGF-I:IGFBP-3 molar ratio, likely due to the lower levels of growth hormone (GH) in older women, 42 as GH regulates and stimulates secretion of IGF-I and IGFBP-3.…”

Section: Cancer Epidemiologysupporting

confidence: 93%

“…46, 47 After adjusting for age, BMI, and reproductive factors, our data agree with prior studies 20-23 that reported higher circulating levels of IGF-I and lower levels of IGFBP-3 in AA vs. Caucasian women. The racial differences in IGF-I levels are also present in children 23 and associated with lifestyle factors (e.g., diet 21, 36 , physical activity 38 , body fat distribution 29, 37, 40 ). The overall agreement of our results with previous findings supports the validity of our IGF data.…”

Section: Discussionmentioning

confidence: 99%

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Serum insulin‐like growth factor (IGF)‐I and IGF binding protein‐3 in relation to terminal duct lobular unit involution of the normal breast in Caucasian and African American women: The Susan G. Komen Tissue Bank

Pfeiffer

Falk

et al. 2018

Intl Journal of Cancer

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Lesser degrees of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini/TDLU, are associated with elevated breast cancer risk. In rodent models, the insulin-like growth factor (IGF) system regulates involution of the mammary gland. We examined associations of circulating IGF measures with TDLU involution in normal breast tissues among women without precancerous lesions. Among 715 Caucasian and 283 African American (AA) women who donated normal breast tissue samples to the Komen Tissue Bank between 2009 and 2012 (75% premenopausal), serum concentrations of IGF-I and binding protein (IGFBP)-3 were quantified using enzyme-linked immunosorbent assay. Hematoxilyn and eosin-stained tissue sections were assessed for numbers of TDLUs ("TDLU count"). Zero-inflated Poisson regression models with a robust variance estimator were used to estimate relative risks (RRs) for association of IGF measures (tertiles) with TDLU count by race and menopausal status, adjusting for potential confounders. AA (vs. Caucasian) women had higher age-adjusted mean levels of serum IGF-I (137 vs. 131 ng/mL, p = 0.07) and lower levels of IGFBP-3 (4165 vs. 4684 ng/mL, p < 0.0001). Postmenopausal IGFBP-3 was inversely associated with TDLU count among AA (RR = 0.49, 95% CI = 0.28-0.84, p-trend = 0.04) and Caucasian (RR =0.64, 95% CI = 0.42-0.98, p-trend = 0.04) women. In premenopausal women, higher IGF-I:IGFBP-3 ratios were associated with higher TDLU count in Caucasian (RR =1.33, 95% CI = 1.02-1.75, p-trend = 0.04), but not in AA (RR =0.65, 95% CI = 0.42-1.00, p-trend = 0.05), women. Our data suggest a role of the IGF system, particularly IGFBP-3, in TDLU involution of the normal breast, a breast cancer risk factor, among Caucasian and AA women.

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Section: Cancer Epidemiologysupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Serum insulin‐like growth factor (IGF)‐I and IGF binding protein‐3 in relation to terminal duct lobular unit involution of the normal breast in Caucasian and African American women: The Susan G. Komen Tissue Bank

Pfeiffer

Falk

et al. 2018

Intl Journal of Cancer

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“…However, several studies support the presence of a positive [ 31 ], non-linear [ 32 – 35 ] or null [ 36 – 38 ] relationship between serum IGF-I levels and BMI. The largest study was conducted by Crowe et al in 2011 [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Zhu

Gong

et al. 2017

PLoS ONE

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PurposeTo determine serum insulin-like growth factor 1 (IGF-I) levels in healthy Chinese adults, establish reference ranges for serum IGF-I levels and observe the effects of age, sex, body mass index (BMI) and geographical region on serum IGF-I levels.MethodsIn total, 2791 healthy adults (1339 males and 1452 females) from the north (Beijing) and south (Guizhou Province) of China were recruited following a questionnaire survey, physical examination and laboratory examination. Both sexes were divided into 13 groups according to age (18, 19, 20–24, 25–29, 30–34, 35–39, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69 and ≥70 years). The serum IGF-I levels were measured by performing a chemiluminescent assay (Immulite 2000®), and the LMS (Lambda-Mu-Sigma) method was applied to construct smooth centile curves of age-specific IGF-I levels.ResultsSerum IGF-I levels in the adults gradually decreased with increasing age from 18 to 70 years in both the male and female participants. Although the decrease in the level of IGF-1 was more pronounced in females than in males, no significant difference was observed between the sexes, except in the 60- to 64-year-old age group (P = 0.0329). The multiple linear regression model showed that there was an inverse relationship between the serum IGF-I level and BMI (P<0.001), and the serum IGF-I level in the Guizhou population was higher than that in the Beijing population (P<0.05).ConclusionThe normal reference ranges for age- and sex-specific serum IGF-I levels were established for the first time in a large sample of Chinese adults. The serum IGF-I levels were significantly influenced by age, BMI and geographical region.

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“…A major strength of this study is that we investigated the relationship of multiple IGFBPs, in addition to the widely studied IGF-I and IGFBP-3, with quantitative, reliable measures of MD. IGF assays used were also highly reliable, with the IGF proteins demonstrating several expected relationships with breast cancer risk factors [14, 62–67]. For example, we found that IGF-I was inversely associated with age, likely due to declines in growth hormone secretion in with aging [63, 66–70].…”

Section: Discussionmentioning

confidence: 96%

Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Hada

Pfeiffer

et al. 2019

Breast Cancer Res

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Background Mammographic density (MD) is a strong breast cancer risk factor that reflects fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly understood. Insulin-like growth factor binding proteins (IGFBPs) are markers that may be associated with MD given their hypothesized role in breast carcinogenesis. IGFBPs sequester IGF-I, limiting its bioavailability. Prior studies have found positive associations between circulating IGF-I and the IGF-I:IGFBP-3 ratio and breast cancer risk. We evaluated the associations of IGF-I, IGFBP-3, and six other IGFBPs with MD. Methods Serum IGF measures were quantified in 296 women, ages 40–65, undergoing diagnostic image-guided breast biopsy. Volumetric density measures (MD-V) were assessed in pre-biopsy digital mammograms using single X-ray absorptiometry. Area density measures (MD-A) were estimated by computer-assisted thresholding software. Age, body mass index (BMI), and BMI 2 -adjusted linear regression models were used to examine associations of serum IGF measures with MD. Effect modification by BMI was also assessed. Results IGF-I and IGFBP-3 were not strongly associated with MD after BMI adjustment. In multivariable analyses among premenopausal women, IGFBP-2 was positively associated with both percent MD-V ( β = 1.49, p value = 0.02) and MD-A ( β = 1.55, p value = 0.05). Among postmenopausal women, positive relationships between IGFBP-2 and percent MD-V ( β = 2.04, p = 0.003) were observed; the positive associations between IGFBP-2 and percent MD-V were stronger among lean women (BMI < 25 kg/m 2 ) ( β = 5.32, p = 0.0002; p interaction = 0.0003). Conclusions In this comprehensive study of IGFBPs and MD, we observed a novel positive association between IGFBP-2 and MD, particularly among women with lower BMI. In concert with in vitro studies suggesting a dual role of IGFBP-2 on breast tissue, promoting cell proliferation as well as inhibiting tumorigenesis, our findings suggest that further studies assessing the role of IGFBP-2 in breast tissue composition, in addition to IGF-1 and IGFBP-3, are warranted. Electronic supplementary material The online version of this article (10.1186/s13058-019-1162-8) contains supplementary material, which is available to authorized users.

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The association of plasma IGF-I with dietary, lifestyle, anthropometric, and early life factors in postmenopausal women

Cited by 12 publications

References 29 publications

Serum insulin‐like growth factor (IGF)‐I and IGF binding protein‐3 in relation to terminal duct lobular unit involution of the normal breast in Caucasian and African American women: The Susan G. Komen Tissue Bank

Serum insulin‐like growth factor (IGF)‐I and IGF binding protein‐3 in relation to terminal duct lobular unit involution of the normal breast in Caucasian and African American women: The Susan G. Komen Tissue Bank

Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy Chinese adults

Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

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