The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study

Goudarzi, Houman; Araki, Atsuko; Itoh, Shinji; Sasaki, Seiko; Miyashita, Chihiro; Mitsui, Takahiko; Nakazawa, Hiroyuki; Nonomura, Katsuya; Kishi, Reiko

doi:10.1289/ehp142

Cited by 82 publications

(41 citation statements)

References 58 publications

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“…PFOS, but not PFOA were inversely correlated with maternal TSH and positively associated with infant serum TSH (Kato et al 2016). Similarly, PFOS, but not PFOA was negatively associated with glucocorticoids in cord blood (Goudarzi et al 2017).…”

Section: Minatoyamentioning

confidence: 78%

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Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Minatoya

Itoh

Miyashita

et al. 2017

Environmental Research

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Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4ng/mL, respectively. The median total adiponectin and leptin levels were 19.4μg/mL and 6.2ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.

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Section: Minatoyamentioning

confidence: 78%

“…Potential confounding variables were considered based on the previous literatures (Itoh et al 2016;Kato et al 2016;Goudarzi et al 2017). Medical record and questionnaires were used for obtaining data.…”

Section: Statistical Analysesmentioning

confidence: 99%

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Minatoya

Itoh

Miyashita

et al. 2017

Environmental Research

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“…DHEA decreased (Q4 vs. Q1: β = − 1.23 ng/mL, 95% CI − 1.72 to − 0.25) in association with PFOA. [ 44 ] DEHP Cord reproductive hormones 202 MEHP was associated with reduced levels of T/E2, P4, and inhibin B. Inverse associations between maternal MEHP levels T/E2, P4, inhibin B, and INSL3 for males. [ 42 ] Cord steroid hormones 202 MEHP was associated with reduced cortisol and cortisone levels and glucocorticoid/adrenal androgen ratio whereas increased DHEA levels and DHEA/androstenedione ratio.…”

Section: Resultsmentioning

confidence: 99%

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Kishi

Araki

Minatoya

et al. 2017

Environ Health Prev Med

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The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose of this report is to update the progress of the Hokkaido Study, to summarize the recent results, and to suggest future directions. In particular, this report provides the basic characteristics of the cohort populations, discusses the population remaining in the cohorts and those who were lost to follow-up at birth, and introduces the newly added follow-up studies and case-cohort study design. In the Sapporo cohort of 514 enrolled pregnant women, various specimens, including maternal and cord blood, maternal hair, and breast milk, were collected for the assessment of exposures to dioxins, polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances, phthalates, bisphenol A, and methylmercury. As follow-ups, face-to-face neurobehavioral developmental tests were conducted at several different ages. In the Hokkaido cohort of 20,926 enrolled pregnant women, the prevalence of complicated pregnancies and birth outcomes, such as miscarriage, stillbirth, low birth weight, preterm birth, and small for gestational age were examined. The levels of exposure to environmental chemicals were relatively low in these study populations compared to those reported previously. We also studied environmental chemical exposure in association with health outcomes, including birth size, neonatal hormone levels, neurobehavioral development, asthma, allergies, and infectious diseases. In addition, genetic and epigenetic analyses were conducted. The results of this study demonstrate the effects of environmental chemical exposures on genetically susceptible populations and on DNA methylation. Further study and continuous follow-up are necessary to elucidate the combined effects of chemical exposure on health outcomes.

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“…Consistent with our findings, Apelberg et al (2007) reported that the multiparous births group has lower PFOA concentrations than primiparous births (p = 0.02) in 299 cord blood samples from the Baltimore THREE Study in -2005 also indicated a correlation between parity and cord PFOA levels among 70 South Koreans (OR = 0.32, 95% CI 0.1, 1.05). Many studies demonstrated a negative correlation between PFOA in maternal and parity (Goudarzi et al 2016;Kato et al 2014;Kishi et al 2015;Lee et al 2016), and concentrations of PFOA in cord serum were highly correlated with those in maternal serum Needham et al 2011). Perhaps these findings partly explain the difference of cord PFOA concentration due to parity.…”

Section: Isomeric Profile Of Pfoa In Cord Serummentioning

confidence: 97%

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Zhang

Zeng

Qian

et al. 2017

Environ Sci Pollut Res

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Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

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The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study

Cited by 82 publications

References 58 publications

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

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