The association of remotely-sensed outdoor temperature with blood pressure levels in REGARDS: a cross-sectional study of a large, national cohort of African-American and white participants

Kent, Shia T.; Howard, George; Crosson, William L.; Prineas, Ronald J.; McClure, Leslie A.

doi:10.1186/1476-069x-10-7

Cited by 37 publications

(31 citation statements)

References 39 publications

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“…33,34 Our analysis extends previous findings on outdoor temperature and blood pressure, which consistently found lower SBPs and DBPs with higher outdoor temperatures. [10][11][12][13] Similarly, results from seasonality studies reported higher blood pressure values in cold winters compared with hot summers. [15][16][17][18][19][20][21] The association between outdoor temperature and blood pressure found in the present study was independent of Hb and vice versa.…”

Section: Discussionmentioning

confidence: 78%

“…Thus, high daily temperatures coincided with lower systolic (SBP) and diastolic (DBP) blood pressure. [10][11][12][13][14] Moreover, during a cold winter, blood pressures were significantly higher than in a hot summer. [15][16][17][18][19][20][21] In addition to temperature, it has been suggested that other climate parameters like humidity are related to blood pressure.…”

Section: Introductionmentioning

confidence: 99%

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Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Hurk

Kort

Deinum

et al. 2015

Journal of the American Society of Hypertension

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Hurk

Kort

Deinum

et al. 2015

Journal of the American Society of Hypertension

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“…9,12,14,17,18 Only few studies investigated the influence of season on BP adjusted for temperature 11,13 or conversely adjusted the influence of temperature for season. 32,33 Madsen and Nafstad 13 reported that in 18 770 Oslo citizens, office BP was highest in winter, but that adjustment for temperature removed the significance of this finding. Generally, daily temperature reflects the short-term variation in environmental BP cues, whereas season stands for the medium-to-long-term variation.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Blood Pressure Rhythmicity in Relation to Environmental and Genetic Cues in Untreated Referred Patients

et al. 2017

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Abstract-No previous study has addressed the relative contributions of environmental and genetic cues to the diurnal blood pressure rhythmicity. From 24-hour ambulatory recordings of systolic blood pressure obtained in untreated patients (51% women; mean age, 51 years), we computed the night-to-day ratio in 897 and morning surge in 637. Environmental cues included season, mean daily outdoor temperature, atmospheric pressure, humidity and weekday, and the genetic cues 14 single nucleotide polymorphisms in 10 clock genes. Systolic blood pressure averaged (±SD) 126.7±11.9 mm Hg, night-to-day ratio 0.86±0.07, and morning surge 24.8±10.7 mm Hg. In adjusted analyses, night-to-day ratio was 2.4% higher in summer and 1.8% lower in winter (P<0.001) compared with the annual average with a small effect of temperature (P=0.079); morning surge was 1.7 mm Hg lower in summer and 1.1 mm Hg higher in winter (P<0.001). The other environmental cues did not add to the night-to-day ratio or morning surge variance (P≥0.37). Among the 14 genetic variations, only CLOCK rs180260 was significantly associated with morning surge after adjustment for season, temperature, and other host factors and after Bonferroni correction (P=0.044). In CLOCK rs1801260 C allele carriers (n=83), morning surge was 3.7 mm Hg higher than in TT homozygotes (n=554). Of the night-to-day ratio and morning surge variance, season and temperature explained ≈8% and ≈3%, while for genetic cues, these proportions were ≈1% or less. In conclusion, environmental compared with genetic cues are substantially stronger drivers of the diurnal blood pressure rhythmicity. Methods Study PopulationAs described elsewhere, 24,25 we recruited consecutive patients referred for ambulatory BP monitoring to the Hypertension Outpatient Clinic of Ruijin Hospital, Shanghai, China. We adhered to the principles of the Declaration of Helsinki. The Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, approved the study protocol. All patients gave informed written consent.Of patients referred from December 2008 until November 2012, 929 were eligible for inclusion in the present analysis because they were not on antihypertensive drug treatment or off antihypertensive medication for at least 2 weeks because they had both their clinic and 24-hour ambulatory BP measured and because they had been genotyped for the SNPs of interest. For analysis of the night-to-day BP ratio, we excluded 32 participants because their ambulatory BP recording was unsuccessful (n=24) or because of missing genotypes (n=8). For analysis of the morning surge, we discarded an additional 260 participants because they had not completed a diary, so that reliably differentiating between the awake and asleep periods of the day was impossible. Thus, the number of participants analyzed totaled 897 for the night-to-day BP ratio and 637 for the morning BP surge. BP MeasurementPhysicians measured the office BP after the patients had rested in the sitting position for at least 5 minutes. They obtained ...

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“…[1][2][3][4][5][6] An inverse association between ambient temperature and BP has been observed in several studies.…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6] An inverse association between ambient temperature and BP has been observed in several studies.7-9 Thermoregulatory vasoconstriction, which increases arterial BP significantly, 10 is an adaptive response to provide enhanced circulatory function for the protective mechanisms that are activated to maintain temperature in cold weather (nonshivering thermogenesis and increased metabolic rate). …”

mentioning

confidence: 99%

Blood Pressure Response to Patterns of Weather Fluctuations and Effect on Mortality

et al. 2013

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T here is growing evidence that outdoor temperature is a major determinant of the observed seasonal fluctuations in blood pressure (BP) with higher and lower BP in winter and summer, respectively. [1][2][3][4][5][6] An inverse association between ambient temperature and BP has been observed in several studies.7-9 Thermoregulatory vasoconstriction, which increases arterial BP significantly, 10 is an adaptive response to provide enhanced circulatory function for the protective mechanisms that are activated to maintain temperature in cold weather (nonshivering thermogenesis and increased metabolic rate). 2,11Elevation of BP induced by a longer period of cold exposure is not reversible after return to a thermo-neutral temperature in animal studies 12 and may result in cold-induced hypertension. Although several studies explored the effects of seasonal variations on BP, few studies have looked at longitudinal BP changes in relation to fluctuations in weather patterns. To our knowledge, there are no studies that examined the role of sunshine, rain, or air frost on BP. It is unclear whether BP response to weather parameters like temperature, rainfall, frost, and sunshine is similar in everybody. If there is heterogeneity in weather-related BP response, it would be important to know whether intraindividual and interindividual responsiveness to weather changes can predict long-term risk. The aim of this study was to determine the within-subject changes in BP in response to a range of weather patterns and test whether individual BP response to the weather is predictive of long-term mortality and BP control in a large hypertensive cohort. Methods Study PopulationThe Glasgow Blood Pressure Clinic provides secondary and tertiary level service to individuals with hypertension from the West of Scotland. The details of the study population and settings, clinical Abstract-Very few studies have looked at longitudinal intraindividual blood pressure responses to weather conditions.There are no data to suggest that specific response to changes in weather will have an impact on survival. We analyzed >169 000 clinic visits of 16 010 Glasgow Blood Pressure Clinic patients with hypertension. Each clinic visit was mapped to the mean West of Scotland monthly weather (temperature, sunshine, rainfall) data. Percentage change in blood pressure was calculated between pairs of consecutive clinic visits, where the weather alternated between 2 extreme quartiles (Q 1 -Q 4 or Q 4 -Q 1 ) or remained in the same quartile (Q n -Q n ) of each weather parameter. Subjects were also categorized into 2 groups depending on whether their blood pressure response in Q 1 -Q 4 or Q 4 -Q 1 were concordant or discordant to Q n -Q n . Generalized estimating equations and Cox proportional hazards model were used to model the effect on longitudinal blood pressure and mortality, respectively. Q n -Q n showed a mean 2% drop in blood pressure consistently, whereas Q 4 -Q 1 showed a mean 2.1% and 1.6% rise in systolic and diastolic blood pressure, respectively. However,...

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The association of remotely-sensed outdoor temperature with blood pressure levels in REGARDS: a cross-sectional study of a large, national cohort of African-American and white participants

Cited by 37 publications

References 39 publications

Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Diurnal Blood Pressure Rhythmicity in Relation to Environmental and Genetic Cues in Untreated Referred Patients

Blood Pressure Response to Patterns of Weather Fluctuations and Effect on Mortality

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