The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population

Chen, Tzu-Hua; Huang, Joh-Jong; Lee, Hsiang‐Ying; Kung, Wei-Shyang; Luo, Kuei-Hau; Lu, Jiayi; Chuang, Hung‐Yi

doi:10.3390/ijerph18178965

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…In 2021, a meta-analysis of 43 studies that analyzed the association of blood lead levels with renal function showed that high BUN is a valuable prognostic test for lead-associated kidney disease ( 129 ). A study on selenium from Taiwan and another on mercury from Colombia link the renal toxicity of these metals to genetic predisposition ( 130 , 131 ).…”

Section: Occupation and The Kidneymentioning

confidence: 99%

Where do you live and what do you do? Two questions that might impact your kidney health

Aoun¹,

Chelala²

2022

Front. Nephrol.

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In many cases the social determinants of health need to be assessed through their interaction with environmental factors. This review looks at the impact of physical location and occupation of individuals on their kidney health. It examines the effect of living at high altitude on kidney function and the relationship between extreme cold or hot temperatures and the incidence of kidney injury. It reviews as well the many occupations that have been linked to kidney disease in high-income and low-and-middle-income countries. As a conclusion, this overview proposes preventive recommendations that could be individualized based on weather, altitude, socio-economic level of the country and occupation of the individual.

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Section: Occupation and The Kidneymentioning

confidence: 99%

Where do you live and what do you do? Two questions that might impact your kidney health

Aoun¹,

Chelala²

2022

Front. Nephrol.

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“…Previous animal studies have reported that treatment of Se can alleviate the nephrotoxicity that is induced by lead nitrate ( 7 ), cyclophosphamide ( 8 ), cisplatin ( 9 ), or streptozotocin ( 10 ), and Se deficiency has direct effects on renal injury ( 11 ). Population studies have also observed that plasma Se levels in nondialyzed CKD patients are lower than those of their healthy counterparts ( 12 , 13 ). However, longitudinal data on the association between selenium and renal function remain limited ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Inverse Association Between Baseline Plasma Selenium Concentrations and Risks of Renal Function Decline in Hypertensive Adults

Song

Liu

et al. 2022

The Journal of Nutrition

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Background The kidney has the highest level of selenium (Se) in the body, but the role of plasma Se in chronic kidney disease is uncertain. Objective We aimed to investigate the longitudinal association between baseline plasma Se and renal function decline in adults with hypertension and to explore possible effect modifiers. Methods This was a post-hoc analysis of 935 men and women with hypertension aged 40 to 75 years from a folic-acid intervention trial (CSPPT) in China. Baseline plasma Se was analyzed as a continuous variable and as tertiles. The primary outcome was rapid decline in renal function, defined as a mean decline in eGFR ≥5 mL/(min· 1.73m2) per year. Results The median follow-up duration from baseline to outcome was 4.4 years. After multivariate adjustment, there was an inverse association between plasma Se and rapid decline in renal function (per 10-unit increment; OR, 0.85; 95%CI: 0.73, 0.99). When baseline plasma Se was assessed as tertiles, compared to the lowest tertile (<74.5 μg/L), a lower trend of the primary outcome was found in the second tertile (74.5 to <89.4 μg/L; OR, 0.60; 95%CI: 0.34, 1.07) and the highest tertile (89.4 to <150 μg/L; OR, 0.42; 95%CI: 0.22, 0.80) (P for trend = 0.006). Furthermore, the Se-renal association was more pronounced among participants with folic acid treatment or with a higher baseline folate concentration (both P for interaction <0.05). Conclusions In this sample of Chinese adults with hypertension, baseline plasma Se concentrations are inversely associated with the risk of renal function decline.

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“…Most of the previous studies focused on the analysis of As in urine, and less on the blood As. Whether urinary or blood As, many studies have shown that As exposure is inversely related to the glomerular filtration rate (GFR) or to the prevalence of proteinuria; however, the results were not consistent [ 5 , 6 , 7 ]. Furthermore, studies have revealed that chronic As exposure would lead to positive regulation of tumor necrosis factor- alpha (TNF-α) mRNA and other related factors, and then to atherosclerosis and skin lesions.…”

Section: Introductionmentioning

confidence: 99%

Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR)

Fang

Lin

Lee

et al. 2022

IJERPH

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When poisons enter the human body, tumor necrosis factor (TNF-α) will increase and cause damage to tissues through oxidative stress or inflammatory reaction. In previous studies, arsenic (As) has known to cause many health problems. Some studies have shown that As exposure is negatively correlated with estimated glomerular filtration rate (eGFR), or with the prevalence of proteinuria. At present, there are few studies focusing on the effects of As exposure and TNF-α single nucleotide polymorphism (SNP) to eGFR; thus, this study was intended to explore the interactions between TNF-α SNPs and plasma As and their effects on eGFR. A cohort of 500 adults, aged 30 to 70 years, was randomly selected from Taiwan Biobank (TWB). We used the gene chip to screen out seven SNPs of the TNF-α gene and used the results, combined with questionnaires, biochemical tests, and stored plasma samples from the TWB, for the analysis of As by inductively coupled plasma mass spectrometry (ICP-MS). After adjustments for BMI, hypertension, hyperlipidemia, kidney stones, and smoking habits, multiple regression statistics were performed to explore the interaction between SNPs and plasma As with eGFR. In this sample of the general population, plasma As had a significant association with the decline of eGFR (β (SE) = −7.92 (1.70), p < 0.0001). TNF-α gene SNP rs1800629 had the property of regulating TNF-α, which interacts with plasma As; individuals with the AG type had a significantly lower eGFR than those with the GG type, by 9.59 mL/min/1.73 m2 (p < 0.05), which, regarding the dominant model, could infer that the A allele is a risk allele. SNP rs769177 had no interaction with plasma As; however, participants with the TT or TC type had significantly higher eGFR levels than the CC carriers, by 4.02 mL/min/1.73 m2 (p < 0.05). While rs769176 interacted with plasma As, if a person with the TC type had a higher plasma As concentration, that would sustain higher eGFR. This study found that certain SNPs of the TNF-α gene would be robust to the decline of eGFR caused by As exposure. Still, we need further research to confirm the protective regulation mechanism of these SNPs.

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The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population

Cited by 3 publications

References 43 publications

Where do you live and what do you do? Two questions that might impact your kidney health

Where do you live and what do you do? Two questions that might impact your kidney health

Inverse Association Between Baseline Plasma Selenium Concentrations and Risks of Renal Function Decline in Hypertensive Adults

Interaction between Single Nucleotide Polymorphisms (SNP) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Plasma Arsenic and the Effect on Estimated Glomerular Filtration Rate (eGFR)

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