The association of renal tubular acidosis and cyanotic congenital heart disease

ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

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“…52 In addition, cyanotic patients may develop secondary renal tubular acidosis with subsequent normal anion gap metabolic acidosis. 53 …”

Section: Overviewmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

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“…Successful repair of the heart anomaly should result in prompt resolution of cyanosis and metabolic acidosis (within 48 h) [1]. Persistence of metabolic acidosis beyond this period and continued failure to thrive should alert the clinician to an alternative (extracardiorespiratory) cause, such as a renal tubular acidification defect, as in this case.…”

Section: Distal (Type I) Renal Tubular Acidosis (Rta)mentioning

confidence: 93%

“…After successful cardiac surgery, the patient's acid base status and proximal tubular bicarbonate reabsorption both normalized. Vida et al studied 73 patients with cyanotic heart diseases and found 56 patients with metabolic acidosis [1]. Fortyeight patients had normal anion gap metabolic acidosis.…”

Section: Commentarymentioning

confidence: 99%

Failure to thrive and nephrolithiasis in a boy with congenital cyanotic heart anomaly: answers

et al. 2011

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“…Clinical research activities have begun, with most of the clinical studies undertaken subsequently published in prestigious international scientific journals. [91][92][93][94][95][96][97][98][99][100][101][102] Aldo has also trained three young foreign surgeons (Figs 4 and 5), in addition to the three members of his permanent surgical staff. These surgeons came from Venezuela, El Salvador, and one of us (VLV) from Italy.…”

Section: Contributions To Cardiac Surgerymentioning

confidence: 99%

Aldo R. Castañeda

2006

Self Cite

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Fame, 1-7 the internationally known paediatric cardiac surgeon, Aldo R. Castañeda (Fig. 1). The life and work of Aldo, including his many outstanding contributions to paediatric cardiac surgery, to surgical education, research and teaching, serve as an example and great inspiration for past and new generations in our speciality. Aldo was a pioneer in paediatric cardiac surgery; and his contribution to the surgical treatment of congenital cardiac disease in particular has proved to be of historic importance. We shall offer a short analysis of his life, a gentlemen citizen of the world, who, after his retirement from the surgical leadership of the Children's Hospital of Boston and Harvard Medical School, returned to Guatemala to continue his mission by developing the first and the only programme for paediatric cardiac surgery in Central America. Early life and education Aldo Castañeda was born in Nervi, close to Genoa, Italy, on July 17, 1930. His mother, Isabel Heuberger, was from Nicaragua, and his father, Ricardo Castañeda Palacios, from Guatemala. In 1935, the family moved to Munich, where his father studied medicine. Aldo started primary school in Munich in 1936. When the second World War began in 1939, the state of the family as Guatemalan citizens made them aliens and foreign enemies, so they were not allowed to leave Germany. In 1944, their home was completely destroyed during an air raid. The difficult war years, especially living under the totalitarian rule of Nazism, impacted profoundly Aldo's subsequent vision of life. He spent one more year at the Landschulheim in Schoendorf, a school in Bavaria widely recognized for its academic excellence. Then, after a brief first

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The association of renal tubular acidosis and cyanotic congenital heart disease

Cited by 5 publications

References 6 publications

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Failure to thrive and nephrolithiasis in a boy with congenital cyanotic heart anomaly: answers

Aldo R. Castañeda

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