The association of scalp psoriasis with overall psoriasis severity and koebnerization in children: cross‐sectional findings from the Dutch Child‐CAPTURE registry

Bronckers, Inge M G J; Maatkamp, M.; Kievit, Wietske; Kerkhof, P.C.M. van de; Jong, E.M.G.J. de; Seyger, M.M.B.

doi:10.1111/bjd.18168

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Nevertheless, the Koebner phenomenon is best described in association with psoriasis and there have been a number of studies showing the association of Koebnerization with psoriasis [11,12]. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes, and on keloids suggest that the Koebner phenomenon may be responsible for these psoriatic lesions [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Liu

2019

Bioscience Reports

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Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.

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Section: Introductionmentioning

confidence: 99%

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Liu

2019

Bioscience Reports

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“…Analysis of psoriasis in 402 children (<18 y.o.) as part of the Child-CAPTURE registry (Continuous Assessment of Psoriasis Treatment Use Registry) program showed that the percentage of the affected scalp area was significantly higher in children with a positive Koebner phenomenon vs. children with a negative Koebner phenomenon (50% vs. 25% of the affected scalp, p=0,001) [91]. Scalp psoriasis was observed in 87.6% of children, of whom as much as 35.8% reported scalp psoriasis as the initial place of the disease [91].…”

Section: Mechanical Traumamentioning

confidence: 99%

The impact of external factors on psoriasis

Owczarczyk‐Saczonek

Kasprowicz-Furmańczyk

Krajewska–Włodarczyk

et al. 2022

Postępy Higieny I Medycyny Doświadczalnej

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Psoriasis is one of the most common chronic inflammatory skin diseases, constituting a significant health and socioeconomic problem. Despite numerous therapeutic options, the results of treatment very often remain insufficient. It is extremely important to remember that many external factors impact the effectiveness of therapy. This article discusses the importance of emollients in therapy and the influence of infectious agents and injuries on the course of psoriasis. Understanding the above-mentioned factors in the treatment of psoriasis is critical to achieve satisfactory therapeutic effects.

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“…No such associations have been documented for adolescents with psoriasis, with the possible exception to the implication of scratching in the maintenance of scalp psoriasis. 25 Systemic drugs (beta-blockers, lithium, antimalarials, etc.) and HIV infection, are less frequently implicated in the onset of psoriasis in adolescents than they are in adults.…”

Section: Evolution Of the Psoriasis Triggering Factorsmentioning

confidence: 99%

“…Scalp psoriasis has been associated with an increase in the severity of psoriasis and with the Koebner phenomenon, suggesting a possible role for trauma or scratching in the aggravation of scalp psoriasis. 25 In adults, scalp psoriasis is associated with psoriatic arthritis but there are no data confirming such an association in children or adolescents.…”

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confidence: 99%

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

Mahé

2020

PTT

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The skin is at the interface between the body and its environment and is therefore at the center of adolescent concerns during this period of identity formation and increased awareness of body image issues, and stigmatization. Managing an adolescent with psoriasis involves managing the illness and the individual during their transition from being an older child to a young adult. In addition to ensuring that the patient adheres to treatments and is engaged with the therapeutic strategy, dermatologists may also need to manage issues linked to unspoken suffering or conflicts between the adolescent and their parents, who are often present during consultations. The impact of psoriasis on the social interactions, school life and sexuality of the patients, together with the influence of the internet and social networks, also have to be taken into account. In this review, we summarize the epidemiologic, clinical, and therapeutic data available on psoriasis in adolescents, and propose specific management strategies, adapted to the 21st century, for patients in this age group.

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The association of scalp psoriasis with overall psoriasis severity and koebnerization in children: cross‐sectional findings from the Dutch Child‐CAPTURE registry

Abstract: The authors thank all the clinicians who referred the patients included in this study, the technical teams of the eight laboratories and the French Network of laboratories specialized in molecular diagnosis of CF (GenMucoFrance).

Cited by 4 publications

References 7 publications

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

The impact of external factors on psoriasis

<p>Optimal Management of Plaque Psoriasis in Adolescents: Current Perspectives</p>

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