The association of serum lipid levels with colorectal cancer recurrence

Brantley, Kristen; Riis, Anders H.; Erichsen, Rune; Thorlacius-Ussing, Ole; Møller, Holger Jon; Lash, Timothy L.

doi:10.1016/j.canep.2020.101725

Cited by 17 publications

(14 citation statements)

References 42 publications

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“…A recent prospective cohort study by Brantley et al [ 33 ] involved 341 CRC patients, and their lipoprotein changes were monitored for a year. Analysis performed considered factors such as age, sex, year of diagnosis, chemotherapy treatment stage, NSAID, aspirin, and statin use.…”

Section: Discussionmentioning

confidence: 99%

Lipoproteins as Markers for Monitoring Cancer Progression

Maran

Hamid

2021

Journal of Lipids

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Lipoproteins are among the contributors of energy for the survival of cancer cells. Studies indicate there are complex functions and metabolism of lipoproteins in cancer. The current review is aimed at providing updates from studies related to the monitoring of lipoproteins in different types of cancer. This had led to numerous clinical and experimental studies. The review covers the major lipoproteins such as LDL cholesterol (LDL-C), oxidized low-density lipoprotein cholesterol (oxLDL-C), very low-density lipoprotein cholesterol (VLDL-C), and high-density lipoprotein cholesterol (HDL-C). This is mainly due to increasing evidence from clinical and experimental studies that relate association of lipoproteins with cancer. Generally, a significant association exists between LDL-C with carcinogenesis and high oxLDL with metastasis. This warrants further investigations to include Mendelian randomization design and to be conducted in a larger population to confirm the significance of LDL-C and its oxidized form as prognostic markers of cancer.

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Section: Discussionmentioning

confidence: 99%

Lipoproteins as Markers for Monitoring Cancer Progression

Maran

Hamid

2021

Journal of Lipids

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“…The abnormal rate of oocytes of the tumor-bearing group (57.10%) was increased compared with that of the control group (41.90%), although the number of abnormal oocytes in the control group was higher than that in a previous report (39 abnormal oocytes out of 93 oocytes) (16), which may be associated with the batch deference of mice. It was previously reported that the growth and survival of tumor cells depended on lipid metabolism, as the lipids could provide the energy for the proliferation of tumor cells (17). Moreover, Wang et al (18) reported that the levels of TG, TC and low-density lipoprotein were negatively associated with the number of normal fertilized oocytes, and that the TG levels were negatively associated with the number of oocytes and cleavage embryos.…”

Section: Discussionmentioning

confidence: 97%

Sarcoma‑180 tumor affects the quality of oocytes in mice

et al. 2021

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Numerous factors can affect the quality of oocytes; however, the effects of cancer on the quality of oocytes and the underlying mechanisms remain unclear. In the present study, the effects of the sarcoma-180 (S-180) cell line on the quality of oocytes were investigated using S-180 tumor-bearing mice. In total, 42 female C57BL/6J mice were randomly divided into the tumor-bearing group and the control group, with 21 mice per group. The weight of the mice and ovaries were recorded, and blood glucose, serum insulin, lipopolysaccharide, triglyceride (TG) and total cholesterol (TC) levels were analyzed using the corresponding detection kits. Hematoxylin and eosin staining was performed to observe the pathological changes of the ovarian tissue, and reverse transcription-quantitative PCR (RT-qPCR) was used to analyze the expression levels of meiosis arrest female 1 (MARF1), SUMO-specific protease 7 (SENP7), aralkylamine N-acetyltransferase (AANAT), cell division cycle 25B and glycine-rich protein 3. The results of the present study revealed that the number of oocytes in the two groups of mice was similar; however, the number of abnormal oocytes was increased in the tumor-bearing group. The serum levels of TG and TC were significantly elevated in the tumor-bearing group compared with in the control group (P<0.01). Additionally, RT-qPCR analysis demonstrated that the expression levels of SENP7 were downregulated, while the expression levels of MARF1 and AANAT were upregulated in the ovaries of the tumor-bearing group compared with in the control group (P<0.01). In conclusion, the findings of the present study suggested that cancer may affect the reproductive system of mice and decrease the quality of oocytes by regulating the expression levels of reproduction-associated genes. These results provided novel insights into the reproductive ability of patients with cancer.

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“…Serum cholesterol is important for cell membrane formations, and changes in cholesterol levels can affect cancer development [12]. Although various studies have been conducted on the involvement of cholesterol in cancer, it remains unknown whether cholesterol levels and the use of statins affect an individual's risk of developing cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Serum cholesterol levels are hypothesized to be markers of tumor progression [12], but the relationship between serum cholesterol levels and CRC is unclear. Studies have shown that low-density lipoprotein cholesterol (LDL-C) is associated with CRC progression [13], highdensity lipoprotein cholesterol (HDL-C) is inversely related to CRC risk [14], and total cholesterol (TC) and triglyceride (TG) levels are positively associated with increased CRC risk [5].…”

Section: Introductionmentioning

confidence: 99%

Do cholesterol levels and continuity of statin use affect colorectal cancer incidence in older adults under 75 years of age?

Han

Kim

2021

PLoS ONE

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Introduction Colorectal cancer(CRC) is 3rd most common cancer and has a relatively high mortality rate. Currently, the relationships between CRC and serum cholesterol or statin treatment, especially in older adults under 75 years of age, remain questionable due to a lack of data. The present study evaluated the association between serum cholesterol levels and statin treatment continuity and CRC risk in older adults under 75 years of age. Methods This study used senior cohort data obtained from the National Health Insurance Service of South Korea. The selected cohort contains 131,266 participants who were enrolled from 2009 to 2011 and followed for up to 5 years. Serum cholesterol levels were classified as categorical variables, and continuity of statin treatment was evaluated based on dyslipidemia diagnosis and average medication possession ratio. We used Cox regression analysis to evaluate the associations between CRC risk and serum cholesterol level or statin use. Results A low level of high-density lipoprotein cholesterol(HDL-C) was significantly associated with high CRC risk compared to an HDL-C level in the normal range(hazard ratio [HR]: 1.197, 95% CI: 1.040–1.377). A high level of low-density lipoprotein cholesterol(LDL-C) was associated with increased CRC risk compared to a normal LDL-C level, but not statistically significant. Statin use was associated with decreased CRC risk, and high medication compliance was inversely associated with CRC risk in patients with and without dyslipidemia. Conclusions Statin use was associated with decreased CRC risk, and high medication compliance was inversely associated with CRC risk in patients with and without dyslipidemia compared to non-use of medication. Regular health examinations can help identify individuals who are vulnerable to CRC, and continued statin use may be associated with a reduced risk of CRC. This is particularly important in patients with diabetes and dyslipidemia.

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The association of serum lipid levels with colorectal cancer recurrence

Cited by 17 publications

References 42 publications

Lipoproteins as Markers for Monitoring Cancer Progression

Lipoproteins as Markers for Monitoring Cancer Progression

Sarcoma‑180 tumor affects the quality of oocytes in mice

Do cholesterol levels and continuity of statin use affect colorectal cancer incidence in older adults under 75 years of age?

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