The association of serum neuron-specific enolase with other disease markers in chronic obstructive pulmonary disease: A case-control study

Li, Jie; Kong, Xinyi; Shu, Wei; Zhang, Wei

doi:10.12669/pjms.345.15145

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…As a result, there was a significant positive correlation between CRP and CA125 and NSE and a significant positive correlation between ESR and NSE. Jie Li et al [23]. studied 102 patients diagnosed with COPD in Nanchang Provincial Chest Hospital in 2017 and found that the serum NSE level of patients with COPD gradually increased with the increase in COPD severity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study

Li,

Feng

et al. 2024

BMC Pediatr

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Background Neurospecific Enolase (NSE), a multifunctional protein, is present in various tissues of the body and plays an important role in many disease processes, such as infection, inflammation, tumours, injury, and immunity. In recent years, the application of NSE in respiratory diseases has become increasingly widespread and a research hotspot. Objective This study aims to explore the relationship between NSE and childhood pneumonia, providing assistance for the diagnosis and assessment of pneumonia. Methods Using prospective research and case-control methods, We selected 129 children with pneumonia hospitalised in Weifang People’s Hospital from September 2020 to April 2022 as the case group. Among them were 67 cases of Mycoplasma pneumoniae pneumonia (MP+), 62 cases of non-Mycoplasma pneumoniae pneumonia (MP -), and 21 cases of severe pneumonia. At the same time, 136 children who underwent outpatient health examinations were selected as the control group. The levels of NSE, ESR, CRP in cases group and NSE in control group were measured separately. Result The NSE levels in the MP + group were 17.86 (14.29–22.54) ng/mL, while those in the MP- group were 17.89 (14.10–21.66) ng/mL, both of which were higher than the control group’s NSE levels of 13.26(12.18,14.44) ng/mL (H = 46.92, P = 0.000). There was no statistically significant difference in NSE levels between the MP + and MP - groups (P > 0.05). The NSE level in the severe pneumonia group was 27.38 (13.95–34.06) ng/mL, higher than that in the mild pneumonia group, which was 17.68 (14.27–21.04) ng/mL, (P = 0.024). The AUC values for diagnosing pneumonia are NSE0.714, CRP0.539, and ESR0.535, with NSE having the highest diagnostic value. Conclusion Serum NSE can serve as an inflammatory indicator for paediatric pneumonia, which has important clinical guidance significance for the diagnosis, condition evaluation, and prognosis of paediatric pneumonia.

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Section: Discussionmentioning

confidence: 99%

Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study

Li,

Feng

et al. 2024

BMC Pediatr

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“…Caution should therefore be exercised in interpreting these data. However, one avenue would be worth exploring given the high rates of NSE expressed in patients with chronic hypercapnia and CO2 retention [68].…”

Section: Effects Of Co2 and Diving On Circulating Markers Of Neuronal...mentioning

confidence: 99%

CO2-Breathing Prior to Simulated Diving Increases Decompression Sickness Risk in a Mouse Model: The Microbiota Trail Is Not Forgotten

Daubresse,

Portas,

Bertaud

et al. 2024

Preprint

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Decompression sickness (DCS) with neurological disorders is the leading cause of diving accidents. Exposure to high levels of CO2 during diving is a safety concern for occupational , groups at risk of DCS. However, the effects of prior exposure to CO2 have never been evaluated. The purpose of this study was to evaluate the effect of CO2 breathing prior to a provocative dive on the occurrence of DCS in mice. 50 mice were exposed to a maximum CO2 concentration of 70 hPa for one hour at atmospheric pressure. Another 50 mice breathing air under similar conditions served as controls. In the AIR group (controls), 22 out of 50 mice showed post-dive symptoms compared to 44 out of 50 in the CO2 group. We found that CO2 breathing is associated with a decrease in body temperature in mice and that CO2 exposure dramatically increases the incidence of DCS. More unexpectedly, it appears that a lower temperature of the animals even before exposure to the accident-prone protocol leads to an unfavorable prognosis. This study also suggests that the composition of the microbiota may influence thermogenesis and thus accidentology. Depending on prior exposure, some bacteria identified in this work could be perceived as protective or pathogenic.

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The association of serum neuron-specific enolase with other disease markers in chronic obstructive pulmonary disease: A case-control study

Cited by 2 publications

References 22 publications

Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study

Evaluation and clinical significance of serum neurospecific enolase in children with pneumonia: a case-control study

CO2-Breathing Prior to Simulated Diving Increases Decompression Sickness Risk in a Mouse Model: The Microbiota Trail Is Not Forgotten

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