The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

Zhang, Ziyu; Dai, Wen; Weng, Shuwei; Luo, Mengdie; Fu, Jiahao; Zadroga, John A.; Spolitu, Stefano; Peng, Daoquan

doi:10.1186/s12944-020-1201-6

Cited by 15 publications

(16 citation statements)

References 33 publications

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“…In contrast to these findings, inverse associations with GUDCA levels 24 and total secondary bile acids 17 have also been reported. In examining total bile acid levels, significant positive associations, 14,15 as well as no associations, 13,17,18,24,25 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Circulating bile acid concentrations and non‐alcoholic fatty liver disease in Guatemala

Rivera-Andrade

Petrick

Álvarez

et al. 2022

Aliment Pharmacol Ther

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Background: Non-alcoholic fatty liver disease (NAFLD) is a major liver disease worldwide. Bile acid dysregulation may be a key feature in its pathogenesis and progression. Aims:To characterise the relationship between bile acid levels and NAFLD at the population level Methods: We conducted a cross-sectional study in Guatemala in 2016 to examine the prevalence of NAFLD. Participants (n = 415) completed questionnaires, donated blood samples and had a brief medical exam. NAFLD was determined by calculation of the fatty liver index. The levels of 15 circulating bile acids were determined by LC-MS/MS. Adjusted prevalence odds ratios (POR adj ) and 95% CI were calculated to examine the relationships between bile acid levels (in tertiles) and NAFLD.Results: Persons with NAFLD had significantly higher levels of the conjugated primary bile acids glycocholic acid (GCA) (POR adj T3 vs T1 = 1.85), taurocholic acid (TCA) (POR adj T3 vs T1 = 2.45) and taurochenodeoxycholic acid (TCDCA) (POR adj T3 vs T1 = 2.10), as well as significantly higher levels the unconjugated secondary bile acid, deoxycholic acid (DCA) (POR adj T3 vs T1 = 1.78) and its conjugated form, taurodeoxycholic acid (TDCA) (POR adj T3 vs T1 = 1.81). Conclusions:The bile acid levels of persons with and without NAFLD differed significantly. Among persons with NAFLD, higher levels of the conjugated forms of CA (i.e. GCA, TCA) and the secondary bile acids that derive from CA (i.e. DCA, TDCA) may indicate there is hepatic overproduction of CA, which may affect the liver via aberrant signalling mediated by the bile acids.

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Section: Discussionmentioning

confidence: 99%

Circulating bile acid concentrations and non‐alcoholic fatty liver disease in Guatemala

Rivera-Andrade

Petrick

Álvarez

et al. 2022

Aliment Pharmacol Ther

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“…In a recent large-scale study, which involved in 152,336 participants, 27.5% of the study population had NAFLD [17]. The level of serum TBA in NAFLD patients was significantly higher than health population (3.4 vs.3.0 umol/L, p<0.001), however serum TBA level was not independently associated with NAFLD in multivariate regression analysis.…”

Section: Discussionmentioning

confidence: 90%

“…The recent large-scale population study showed no association between serum total bile acid and NAFLD [17]. Differences in control populations and the degree of insulin resistance or T2DM severity are potential confounding factors between these studies.…”

Section: Discussionmentioning

confidence: 91%

Increased serum total bile acid is independently associated with non-alcoholic steatohepatitis in non-diabetes population

Li¹,

Ma²,

Gu³

et al. 2020

Preprint

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Background and aims Bile acids, which modulate the glycose and lipid metabolism, play an important role in the development of non-alcoholic fatty liver disease (NAFLD). This study aims to explore the association between serum total bile acid (TBA) and non-alcoholic steatohepatitis (NASH) in the general population from a large clinical dataset. Methods NAFLD individuals confirmed by ultrasonography were enrolled in the study. The NASH was defined as the NAFLD individual with abnormal liver function, and non-alcoholic fatty liver (NAFL) was defined as the NAFLD individual with normal liver function. The demographic characters, biochemical results including serum TBA were compared between NASH and NAFL patients. The independently associated factors with NASH were investigated by multivariate logistic regression analysis. Results A total of 6862 individuals were enrolled in the study, of which 23.7% were NASH. The median age was 45 (39-55) years old, and the BMI was 26.9(25.1-28.9) kg/m 2 . The NASH patients showed higher levels of serum TBA compared to the NAFL patients [3.30(2.30-5.0) μmol/L vs. 2.70(1.90-4.20) μmol/L, P <0.001]. The prevalence of NASH tended to increase with the increasing of serum TBA level ( P <0.001). Multivariate logistic regression analysis showed the age, male, serum TBA levels, diabetes mellitus (DM), serum uric acid, total cholesterol and triglyceride were independent risk factors for NASH ( P <0.05). Stratification analysis according to DM status showed that serum TBA was independently associated with NASH in individuals without DM (OR: 1.55, 95% CI: 1.11-2.13, P =0.008), while not in individuals with DM (OR: 1.32, 95% CI: 0.53-2.96, P =0.515). Conclusion Serum TBA level was significantly higher in NASH patients than in NAFL patients, and was independently associated with NASH in non-diabetes population.

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“…In a recent large-scale study conducted by Zhang et al [14], which involved 152,336 participants, 27.5% of the study population had NAFLD. The level of serum TBA in patients with NAFLD was significantly higher than that in those without NAFLD (3.4 vs. 3.0 μmol/L, p ≤ 0:01).…”

Section: Discussionmentioning

confidence: 98%

“…In a cross-sectional study with large sample sizes, Zhang et al [14] showed that serum TBA levels were higher in patients with NAFLD than in those without NAFLD. However, multivariate logistic regression analysis showed no association between serum TBA and NAFLD after adjusting for confounding factors, which may be partly attributed to the diverse compositions of circulating TBAs.…”

Section: Introductionmentioning

confidence: 99%

Serum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated with Nonalcoholic Fatty Liver Disease: A Retrospective Cross-Sectional Study

et al. 2021

BioMed Research International

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Introduction and Aims. Bile acids play an essential role in the progression of nonalcoholic fatty liver disease (NAFLD). This study was aimed at investigating the association of the serum glycocholic acid- (GCA-) to-total bile acid (TBA) ratio with NAFLD in the general population. Materials and Methods. A total of 6708 subjects (2859 cases with NAFLD and 3849 controls) were enrolled in the development cohort and additional 1568 subjects (784 cases with NAFLD and 784 controls) in an independent validation cohort. Demographic characteristics and biochemical data were compared between subjects with NAFLD and controls. Multivariate logistic regression analysis was performed to determine the association of the GCA-to-TBA ratio with NAFLD. A novel model incorporating the GCA-to-TBA ratio was developed for screening NAFLD from the general population. Results. The serum TBA and GCA levels were significantly higher in subjects with NAFLD than in those without NAFLD (2.8 (2.0-4.2) μmol/L vs. 2.5 (1.8-3.7) μmol/L and 1.30 (1.10-1.53) μg/mL vs. 1.28 (1.08-1.50) μg/mL, respectively, all p ≤ 0.01 ), whereas the serum GCA-to-TBA ratio was significantly lower in subjects with NAFLD than in subjects without NAFLD (0.44 (0.33-0.60) vs. 0.48 (0.36-0.64), p ≤ 0.01 ). Logistic regression analysis showed that the GCA-to-TBA ratio was independently associated with NAFLD after adjustment for confounding factors (odds ratio: 0.81, 95% confidence interval (CI): 0.71-0.92, p ≤ 0.01 ). The area under the receiver operating characteristic curve of the novel developed GCA-to-TBA ratio score model in discriminating NAFLD was 0.84 (95% CI: 0.83-0.85) in the development cohort and was 0.91 (95% CI: 0.36-0.65) in the validation cohort. Conclusion. The serum GCA-to-TBA ratio is independently associated with NAFLD. A simple novel model incorporating the GCA-to-TBA ratio score has a good performance in discriminating NAFLD from the general population.

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The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

Cited by 15 publications

References 33 publications

Circulating bile acid concentrations and non‐alcoholic fatty liver disease in Guatemala

Circulating bile acid concentrations and non‐alcoholic fatty liver disease in Guatemala

Increased serum total bile acid is independently associated with non-alcoholic steatohepatitis in non-diabetes population

Serum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated with Nonalcoholic Fatty Liver Disease: A Retrospective Cross-Sectional Study

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