The association of serum uric acid with metabolic syndrome and its components—From a single‐clinical centre in China

Abstract

Background and Objectives Increasing evidence suggests that uric acid (UA) levels may play a role in the MetS. The purpose of this study was the association of serum uric acid with metabolic syndrome and its components from a single‐clinical centre in China. Subjects and Methods We retrospectively analysed the physical examination information of patients at the Health Checkup Centre of the Beijing Friendship Hospital, Capital Medical University in 2018. MetS was defined as ≥3 of the risk factors according to the revised Harmonised criteria. Statistical analyses were performed using the SPSS statistical software package, version 22.0 (IBM Corporation, Armonk, NY, USA). Results A total of 36 663 subjects were retrospectively analysed. The incidence of MetS was 23.6% amongst the study participants and 38.9% in subjects with HUA. The incidence of HUA was 33.3% in the MetS group. Higher SUA levels were correlated with an increased risk of having full MetS, hypertriglyceridemia and low HDL‐C after adjustment (all P < .001 for the trend). Only in males higher SUA levels correlated with an increased risk of being overweight. Individuals with the highest quartile of SUA had no significant association with having HP in males, and a significant association between SUA levels and hypertension was only seen in the highest quartile of females. Males with the highest quartile of SUA (Q4) and females with the higher quartiles of SUA (Q3 and Q4) had no significant association with having hyperglycemia. Conclusion The incidence of HUA was increased in the MetS group consisting of Chinese patient subjects living in Beijing. SUA is strongly associated with full MetS as well as hypertriglyceridemia and low HDL‐C. The relationship between HUA and an overweight BMI, HP and hyperglycemia varied by gender.

Correlation between serum C-peptide-releasing effects and the risk of elevated uric acid in type 2 diabetes mellitus

“…We identified that SUA levels were positively correlated with 1hCp, 2hCp, and the Hyperuricemic patients were older and had higher values of macroalbuminuria, BMI, TC, C-peptide, the prevalence of hypertension, and MetS, but lower values of HDL-c and HbA1c [11]. SUA was also strongly associated with full MetS as well as hypertriglyceridemia [22,23]. Nevertheless, some prospective and retrospective studies have yielded contrary results.…”

The prevalence and associated clinical correlates of hyperuricemia in patients with bipolar disorder

“…Moreover, a meta-analysis of 11 prospective studies indicates an independent and linear dose-dependent relationship between HUA and MetS (Biradar et al, 2020). The HUA is closely associated with the MetS and its components (Borges et al, 2010;Thottam et al, 2017;Zhang et al, 2018;Xu et al, 2021). Here, we showed by the univariate analysis that the BMI, HC, WC, and TG were higher in the HUA subjects than those in the normal individuals, while the HDL-C level, a protective factor for CVD risk, was lower in the HUA group than in the control group.…”

Serum uric acid levels and prognosis of patients with non-alcoholic fatty liver disease

“…Metabolic disorders may play a mediating role in the relationship between UA level and NAFLD outcome. Numerous studies have indicated that increased UA levels are associated with metabolic syndrome 12 , CVD 13 , hypertension 14 , type 2 diabetes 15 , and hypertriglyceridemia 16 . The underlying mechanism among high UA levels, NAFLD, and metabolic syndrome may be insulin resistance caused by hyperuricaemia.…”