The Association of Severe Toxoplasmosis and Some Cytokine Levels in Breast Cancer Patients

Assim, Maha Mustafa; Saheb, Entsar Jabbar

doi:10.24996/ijs.2018.59.3a.6

Cited by 5 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current study is in contradiction with the studies conducted in Baghdad province of Iraq and Egypt (16,17). The distribution of T. gondii infections by place of residence was higher in rural areas (56.6%) than in urban areas (43.3%) in the current study.The results for cancer patients in the present study were consistent with a study conducted in Malaysia (18). Interferons are a group of proteins (cytokines) that are critical for mammalian host resistance to infection.…”

Section: Discussionsupporting

confidence: 91%

The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients

2023

ARI

View full text Add to dashboard Cite

Toxoplasmosis is among the most pervasive zoonotic illnesses in the world. Human infection rates range from 10% to 80% in many countries. Cancer patients receiving chemotherapy are more susceptible to developing acute forms of toxoplasmosis, which can cause brain defects, neurological damage, and encephalitis. The present study aimed to evaluate the effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients from Iraq. This cross-sectional descriptive work was carried out on women who were suffering from breast cancer referring to Al-Haboubi Teaching Hospital in Nasiriya City-Thi-Qar province (Iraq) during the period extended from January to September 2022. About 3 mL of blood was obtained from all participants and sera were collected. Sera were then tested using the enzyme-linked immunosorbent assay (ELISA) kits of Toxoplasma IgM, IgG, and IFN-γ (Nova Tec Immunodiagnostica GmbH, Germany) according to the manufacturer’s protocols. Before blood collection, a printed questionnaire with some demographical information, e.g., age and residence, was completed for participants. The total number of positive patients for T. gondii infection from breast cancer patients in the current study was 60 (85.7%). The results of the analyzing specimens by ELISA test revealed that 85.7% and 74.2% of the patients were positive for IgG and IgM, respectively. The mean level of IFN-γ in breast cancer patients with toxoplasmosis, without toxoplasmosis, and control group was 47.66, 0.00, and 0.57 pg/mL, respectively. Higher IgG and interferon-gamma levels were found in the group of breast cancer patients with toxoplasmosis compared to the group without. According to the ELISA findings, T. gondii was the most common parasite among cancer patients.

show abstract

Section: Discussionsupporting

confidence: 91%

The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients

2023

ARI

View full text Add to dashboard Cite

show abstract

“…Aljubori [15] stated that BC patients aged ≤ 50 years in northern Iraq, while Mutar, et al [16] found that 45% of the Iraqi female patients were ≤ 50 years. Locally, the mean age of the Iraqi women with BC was under 50 years old [15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Gene Polymorphism of Human Lymphotoxin Alpha in Iraqi Breast Cancer Women

Muhammed,

Utba,

Raof

2023

Iraqi Journal of Science

View full text Add to dashboard Cite

The lymphotoxin alpha is a highly polymorphic gene and any genetic variation in it may lead to an increased production of cytokine LTA thus helping tumor development and progression. The aim of this work was to investigate the association of LTA polymorphism with the risk of breast cancer among Iraqi women. The findings of this study demonstrated that the age group > 50 years old formed 52% of the breast cancer patients (P <0.001). Hardy–Weinberg equilibrium analysis revealed that genotype frequencies of most SNPs in BC patients and HC were consistent with HWE. No association was found between LTA polymorphisms and BC. Moreover, seven haplotypes were detected in BC group. However, only one of them developed significant increase; T -A -C -C -G -C –G (0.20 vs. 0.04, OR: 5.931, P = 0.015). Markedly, some SNPs were in a strong LD, while others showed weak or no LD. We can conclude that an insignificant association was found between LTA polymorphisms and breast cancer in Iraqi women.

show abstract

“…Liver function enzymes such as ALT, AST, ALP, D. BILL, T. BILL, and D3 were assayed on an automated biochemical analyzer from Siemens Healthineers, Germany. The tests for serum eotaxin-1, myelin basic protein, and interleukins (9,23,27,37) depended on the sandwich ELISA technique. A specific antibody (pre-coated in the wells) is combined with a sample after addition.…”

Section: Laboratory Assessmentmentioning

confidence: 99%

“…A prominent characteristic of these molecules is their effect on the immune system in relation to the development of cell trafficking and immune tissues and organs. Furthermore, they play an important role in initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosisinfected lungs [27]. Some of these parameters are deemed to be key elements in allergic asthma pathogenesis.…”

Section: Interleukins (Il-9 Il-23 Il-27 and Il-37)mentioning

confidence: 99%

Evaluate the Levels of Serum Eotaxin-1, Myelin Basic Protein, and Some Immunological and Biochemical Markers in Iraqi Patients with Multiple Sclerosis

Sahib,

Sulaiman,

Waheed

et al. 2024

Iraqi Journal of Science

View full text Add to dashboard Cite

The central nervous system (CNS) disease known as multiple sclerosis (MS) is essentially an inflammatory demyelinating condition with a variety of clinical manifestations and variable histological findings. A number of immunological and biochemical markers may alter MS, which is also characterized as an autoimmune illness. MS patients (n = 100) were divided into two groups: newly diagnosed (n = 42) and patients with ongoing treatments (n = 58). These groups were compared to healthy subjects (n = 55); the mean age ±SD was (30±8.46 years), (37±8.06 years), and (31±8.73 years) for MS newly diagnosed patients, patients with ongoing treatments, and healthy subjects, respectively. Studies for serum levels of eotaxin-1, myelin basic protein (MBP), IL-23, 27, 9, and 37 were measured by the ELISA technique. Eotaxin-1, MBP, IL-23, 27, and alkaline phosphate were significantly higher in all MS patient groups, but for IL-37, there was no significant difference between newly diagnosed patients when compared with patients with ongoing treatment. Weak positive correlations were found between IL-9 and myelin (r = 0.282, p≤0.05) and a weak positive correlation between IL-23 and ALP (r = 0.209, p≤0.05) in MS patients. A receiver operating characteristic (ROC) curve analysis was applied for the parameters eotaxin-1, MBP, IL-23, 27, and alkaline phosphate, which showed a high sensitivity according to the area under the curve. The present results conclude that eotaxin-1, MBP, IL-23, 27, and alkaline phosphate can be used as diagnostic markers for multiple sclerosis.

show abstract

The Association of Severe Toxoplasmosis and Some Cytokine Levels in Breast Cancer Patients

Cited by 5 publications

References 27 publications

The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients

The effect of infection with Toxoplasma gondii in inducing interferon-gamma in breast cancer patients

Gene Polymorphism of Human Lymphotoxin Alpha in Iraqi Breast Cancer Women

Evaluate the Levels of Serum Eotaxin-1, Myelin Basic Protein, and Some Immunological and Biochemical Markers in Iraqi Patients with Multiple Sclerosis

Contact Info

Product

Resources

About