The association of SNP rs42688595 in LOC514211 gene with Indonesian-Holstein cow’s reproductive traits

Abstract

The aim of this study was to study the association between SNP (single nucleotide polymorphism) rs42688595 in LOC514211 gene with the reproductive traits on Indonesian Holstein dairy cows. Blood samples and reproduction records from 89 cows were used. The DNA analysis was carried out using the PCR-RFLP method. Cows with AC genotypes showed the lowest days open (152.06 ± 20.54 days) and the lowest calving interval (427.06 ± 20.26 days) (P<0.05) compared to those of CC genotypes (236.46 ± 23.34 and 514.95 ± 22.86 days, respectively) and AA genotypes (270.14 ± 26.27 and 552.06 ± 26.29 days, respectively). The studied SNP was not associated with the age at first calving and service per conception (P>0.05). The LOC514211 rs42688595 shows a potency to be used as a genetic marker for a selection program to produce cows with better reproductive performance. Selection could be done by increasing the genetic frequency of heterozygous animals (AC).