The association of SNP276G&gt;T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

Shin, Min Jeong; Jang, Yangsoo; Koh, Soo Jeong; Chae, Jey Sook; Kim, O. Y.; Lee, J. E.; Ordovas, José M.; Lee, J. H.

doi:10.1038/sj.ijo.0803338

Cited by 45 publications

(29 citation statements)

References 25 publications

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“…However, significant reductions in insulin resistance and increases in adiponectin concentration during weight loss have been observed (Haluzík et al, 2004), and the same results have been found only in patients with the GG genotype but not in T-allele carriers in overweight or obese Koreans (Shin et al, 2006). Furthermore, T allele was related to coronary artery disease risk in Italians (Filippi et al, 2005) and TT genotype was associated with cardiovascular disease risk in a subsample of our study population (Yu et al, 2007).…”

Section: Resultssupporting

confidence: 48%

“…in Korea reported significantly higher serum adiponectin in non-diabetic patients with the TT genotype than in those with the GG or GT genotype (Shin et al, 2006;Jang et al, 2008). However, significant reductions in insulin resistance and increases in adiponectin concentration during weight loss have been observed (Haluzík et al, 2004), and the same results have been found only in patients with the GG genotype but not in T-allele carriers in overweight or obese Koreans (Shin et al, 2006).…”

Section: Resultsmentioning

confidence: 51%

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SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

Hwang

Park

Choi³

et al. 2009

Eur J Clin Nutr

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Few studies have examined an association between SNP276 and the risk of metabolic syndrome (MetS), which accelerates the development of diabetic complications, in patients with type II diabetes mellitus (T2DM). This study examined whether the SNP276G4T polymorphism is associated with risk of MetS in 673 Korean patients with T2DM from an ongoing prospective study. Multiple logistic regression analysis revealed that the OR for MetS was greater in patients with the TT genotype than in those with the GG genotype (OR ¼ 2.071; 95% CI ¼ 1.088-3.943) after adjustment of the putative risk factors for MetS. After examining the relationship between serum adiponectin and MetS risk for each genotype, only in patients with the GT genotype, serum adiponectin was negatively associated with the risk of MetS (OR ¼ 0.287; 95% CI ¼ 0.193-0.427). The SNP276G4T polymorphism may have an independent role in the determination of MetS in Korean patients with T2DM.

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Section: Resultssupporting

confidence: 48%

Section: Resultsmentioning

confidence: 51%

SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

Hwang

Park

Choi³

et al. 2009

Eur J Clin Nutr

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“…Numerous articles have speculated on how the ability to identify an individual's susceptibility to diet-related diseases at an early stage, coupled with diet and lifestyle information focused on known diet-genotype-disease interactions, could increase understanding of the relationship between diet and human health [1, 17, 35, 37, 43, 46-48, 50, 52]. Genotyping of individuals participating in dietary intervention studies was rapidly incorporated into study protocols [7,24,42,50,55] as well as into many of the large ongoing cohort studies which are investigating potential diet-health relationships through observational associations [48,58].…”

Section: Genetic Variation and Nutritionmentioning

confidence: 99%

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Williams¹,

Ordovas

Lairon

et al. 2008

Genes Nutr

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Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair the trust of the general population, especially those who are motivated to improve their health through diet. The other road is uncharted and is being built over the many exciting new developments in life sciences. This new era of nutrition recognizes the complex relation between the health of the individual, its genome, and the life-long dietary exposure, and has lead to the realisation that nutrition is essentially a gene-environment interaction science. This review on the relation between genotype, diet and health is the first of a series dealing with the major challenges in molecular nutrition, analyzing the foundations of nutrition research. With the unravelling of the human genome and the linking of its variability to a multitude of phenotypes from ''healthy'' to an enormously complex range of predispositions, the dietary modulation of these propensities has become an area of active research. Classical genetic approaches applied so far in medical genetics have steered away from incorporating dietary effects in their models and paradoxically, most genetic studies analyzing diet-associated phenotypes and diseases simply ignore diet. Yet, a modest but increasing number of studies are accounting for diet as a modulator of genetic associations. These range from observational cohorts to intervention studies with prospectively selected genotypes. New statistical and All authors are member of The European Nutrigenomics Organisation (http://www.nugo.org). bioinformatics approaches are becoming available to aid in design and evaluation of these studies. This review discusses the various approaches used and provides concrete recommendations for future research. C. M. Williams (&)Hugh

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“…However, this study only assessed the genetic influence on IR using HOMA-IR under a codominant model and not the genetic influence on blood glucose. Furthermore, other studies [13,16,19,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] regarding the association between the ADIPOQ T45G polymorphism and IR have been reported.…”

Section: Discussionmentioning

confidence: 99%

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

et al. 2014

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InsulIn resIstance (Ir) is characterized by a decreased capacity of insulin to perform its normal physiological functions. IR is regulated by both environmental and genetic factors [1,2], and is considered as the core factor in the pathogenesis of metabolic syndrome and obesity. In recent years, numerous studies have revealed abundant information about the molecular mechanism of IR [3,4]. However, the exact pathogenesis underlying the development and progression of IR remains unclear.Adiponectin, the most abundant adipocyte-derived protein, is involved in the control of glucose, fat metabolism, and insulin sensitivity [5,6]. Adiponectindeficient mice exhibit IR and glucose intolerance [7,8], and animal models of obesity and IR show reduced plasma adiponectin levels [9,10]. Adiponectin exerts a potent insulin-sensitizing effect through its receptors AdipoR1 and AdipoR2, leading to the activation Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: A meta-analysis Results of published studies on the association of the ADIPOQ T45G polymorphism with insulin resistance (IR) and blood glucose are conflicting. In this study, we performed a meta-analysis to further investigate such an association. Articles that evaluate the effect of the T45G polymorphism on IR and blood glucose were identified from the PubMed and Embase databases. Five indices, including fasting blood glucose (FBG), fasting insulin (F-insulin), 2-h blood glucose (2-h BG), 2-h insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), were used to assess the effects of the T45G polymorphism on IR and blood glucose under a dominant model. 24 articles involving 7630 subjects were included. Twenty-two studies on FBG, 17 on F-insulin, 20 on HOMA-IR, and 3 on 2-h BG were included. No study on 2-h insulin was found. This meta-analysis revealed no significant association between the ADIPOQ T45G polymorphism and IR and blood glucose in the overall population and subgroup subjects under a dominant model, regardless of whether FBG, F-insulin, 2-h BG, or HOMA-IR was used. The present meta-analysis indicated that the mutation allele may have no function in IR development. The ADIPOQ T45G polymorphism is not associated with IR and blood glucose.

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The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

Cited by 45 publications

References 25 publications

SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

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