The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role

Abdulamir, Ahmed Sahib; Hafidh, Rand R.; Bakar, Fatimah Abu

doi:10.1186/1756-9966-30-11

Cited by 276 publications

(231 citation statements)

References 104 publications

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…Colorectal bacterial populations are responsible for important aspects of both health (synthesis of micronutrients such as Vitamin K, protection of the intestine from pathogenic species) and disease (inflammatory reactions and production of carcinogenic metabolites). In relatively recent publications, authors have described associations between species of bacteria, such as Streptococcus bovis subtypes, 33 and Fusobacterium spp. 34 and colorectal neoplasia.…”

Section: Discussionmentioning

confidence: 99%

Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features

et al. 2013

View full text Add to dashboard Cite

KRAS-mutated carcinomas comprise 35-40% of all colorectal carcinomas but little is known about their characteristics. The aim of this study was to examine the pathological and molecular features of KRAS-mutated colorectal carcinomas and to compare them with other carcinoma subgroups. KRAS mutation testing was performed in 776 incident tumors from the Melbourne Collaborative Cohort Study. O 6 -methylguanine DNA methyltransferase (MGMT) status was assessed using both immunohistochemistry and MethyLight techniques. Microsatellite instability (MSI) phenotype and BRAF V600E mutation status were derived from earlier studies. Mutation in KRAS codon 12 or codon 13 was present in 28% of colorectal carcinomas. Compared with KRAS wildtype carcinomas, KRAS-mutated carcinomas were more frequently observed in contiguity with a residual polyp (38 vs 21%; Po0.001), demonstrated mucinous differentiation (46 vs 31%; P ¼ 0.001) and were associated with different MSI status (Po0.001) and with MGMT methylation (47 vs 21%; P ¼ 0.001). Compared with tumors demonstrating neither BRAF nor KRAS mutation, KRAS-mutated carcinomas showed more frequent location in the proximal colon (41 vs 27%; P ¼ 0.001), mucinous differentiation (46 vs 25%; Po0.001), presence of a contiguous polyp (38 vs 22%; Po0.001), MGMT methylation (47 vs 26%; P ¼ 0.01) and loss of MGMT immunohistochemical expression (27 vs 19%; P ¼ 0.02). KRAS-mutated carcinomas were distributed in a bimodal pattern along the proximal-distal axis of the colorectum. Compared with male subjects, female subjects were more likely to have KRAS-mutated carcinoma in the transverse colon and descending colon (39 vs 15%; P ¼ 0.02). No difference in overall survival was observed in patients according to their tumor KRAS mutation status. In summary, KRAS-mutated carcinomas frequently develop in contiguity with a residual polyp and show molecular features distinct from other colorectal carcinomas, in particular from tumors with neither BRAF nor KRAS mutation.

show abstract

Section: Discussionmentioning

confidence: 99%

Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In addition, patients with IBD were recently demonstrated to have a reduced abundance of some members of the gut microbiota, including Firmicutes and Bacteroidetes (16,17). Streptoccus bovis/ gallolyticus, enterotoxigenic Bacterodies fragillis, and Escherichia coli NC101 have been implicated as risk factors for CRC (18)(19)(20). Furthermore, spontaneous intestinal auto-inflammation in several murine models fails to develop in the germ-free setting (21).…”

mentioning

confidence: 99%

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

Elinav

Huber³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

285

251

View full text Add to dashboard Cite

The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC development, where mice deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome feature enhanced inflammation-induced CRC formation. Intriguingly, WT mice cohoused either with inflammasome-deficient mice or with mice lacking IL-18 feature exacerbated inflammation-induced CRC compared with singly housed WT mice. Enhanced tumorigenesis is dependent on microbiota-induced chemokine (C-C motif) ligand 5 (CCL5)-driven inflammation, which in turn promotes epithelial cell proliferation through local activation of the IL-6 pathway, leading to cancer formation. Altogether, our results mechanistically link the altered microbiota with the pathogenesis of inflammation-induced CRC and suggest that in some conditions, microbiota components may transfer CRC susceptibility between individuals.

show abstract

“…pasteurianus and ssp. macedonicus are less frequently associated with colonic disorders (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Contributions of ENDOBACT multicentric study to the infective endocarditis etiology in Romania

Oprea¹,

Surdeanu²,

Bădescu³

et al. 2013

Romanian Review of Laboratory Medicine

View full text Add to dashboard Cite

show abstract

The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role

Cited by 276 publications

References 104 publications

Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features

Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

Contributions of ENDOBACT multicentric study to the infective endocarditis etiology in Romania

Contact Info

Product

Resources

About