The association of the metabolic syndrome with QTc interval in NHANES III

Faramawi, Mohammed F.; Wildman, Rachel P.; Gustat, Jeanette; Rice, Janet C.; Kareem, Mohammed Y. Abdul

doi:10.1007/s10654-008-9252-4

Cited by 24 publications

(13 citation statements)

References 34 publications

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“…[22][23][24] During LT, these factors can be further aggravated by hypovolemia resulting from bleeding and compression of the inferior vena cava during the anhepatic phase. 25 Additionally, various drugs affecting the QTc interval are administered before and during LT. 26,27 Finally, insulin resistance and the presence of metabolic syndrome are independent risk factors for QTc prolongation, which may further increase CV morbidity and mortality in NASH patients who undergo LT. 28,29 Consistent with previous research, our study demonstrates that NASH patients who undergo LT have overall comparable survival to other etiologies. 13,14,30 Although a higher number of patients died from CV causes in the NASH group (9%), compared to the ETOH group (1%), the difference did not reach statistical significance (P ¼ 0.13).…”

Section: Discussionsupporting

confidence: 90%

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Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

et al. 2012

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Nonalcoholic steatohepatitis (NASH) is an independent predictor of coronary artery disease (CAD). Our aim was to compare the incidence of cardiovascular (CV) events between patients transplanted for NASH and alcohol (ETOH)-induced cirrhosis. This is a retrospective cohort study (August 1993 to March 2010) of 242 patients (115 NASH and 127 ETOH) with 12 months follow-up after liver transplantation (LT). Those with hepatocellular carcinoma or coexisting liver diseases were excluded. Kaplan-Meier's and Cox's proportional hazard analyses were conducted to compare survival. Logistic regression was used to calculate the likelihood of CV events, defined as death from any cardiac cause, myocardial infarction, acute heart failure, cardiac arrest, arrhythmia, complete heart block, and/or stroke requiring hospitalization <1 year after LT. Patients in the NASH group were older (58.4 versus 53.3 years) and were more likely to be female (45% versus 18%; P < 0.001). They were more likely to be morbidly obese (32% versus 9%), have dyslipidemia (25% versus 6%), or have hypertension (53% versus 38%; P < 0.01). On multivariate analysis, NASH patients were more likely to have a CV event <1 year after LT, compared to ETOH patients, even after controlling for recipient age, sex, smoking status, pretransplant diabetes, CV disease, and the presence of metabolic syndrome (26% versus 8%; odds ratio 5 4.12; 95% confidence interval 5 1.91-8.90). The majority (70%) of events occurred in the perioperative period, and the occurrence of a CV event was associated with a 50% overall mortality. However, there were no differences in patient, graft, or CV mortality between groups. Conclusions: CV complications are common after LT, and NASH patients are at increased risk independent of traditional cardiac risk factors, though this did not affect overall mortality. (HEPATOLOGY 2012;56:1741-1750

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Section: Discussionsupporting

confidence: 90%

“…Additionally, various drugs affecting the QTc interval are administered before and during LT 26, 27. Finally, insulin resistance and the presence of metabolic syndrome are independent risk factors for QTc prolongation, which may further increase CV morbidity and mortality in NASH patients who undergo LT 28, 29…”

Section: Discussionmentioning

confidence: 99%

Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

et al. 2012

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“…Our findings are consistent with previous reports in underlining a putative association of QTc prolongation with age, obesity, metabolic syndrome, diabetes and also with hyperglycemia and insulin resistance (Faramawi et al., 2008; Li et al., 2009; Queen et al., 2012). A correlation between blood glucose concentration and QTc interval has also been confirmed in non diabetic patients independently on the aforementioned cardiovascular risk factors, such as dyslipidemia and obesity (Grandinetti et al., 2005; Kubiak et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis

et al. 2016

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Objectives: 1H NMR-metabolomic approach was used to investigate QTc interval correlation with plasma metabolic profiles in shiftworkers. Methods: Socio-demographic data, electrocardiographic QTc interval and plasma metabolic profiles from 32 male shiftworkers, were correlated by multivariate regression analysis. Results: We found a positive correlation between QTc interval values, body mass index, glycemia and lactate level and a negative correlation between QTc interval and both pyroglutamate and 3-hydroxybutyrate plasma level. Conclusions: Our analysis provides evidence of the association between clinical, metabolic profiles and QTc interval values. This could be used to identify markers of early effects and/or susceptibility in shiftworkers.

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“…These changes in ventricular repolarization in diabetic patients are caused by several clinical disorders and/or pathological conditions associated with diabetes, such as hypertension 34 , dyslipidemias 35 , hyperglycemia 2 , hypoglycemia 36 , coronary disease 37 , neuropathy 18 , nephropathy 38 , heart failure 39 , etc. These conditions are responsible for the onset of metabolic disorders, electrolyte disturbances, imbalances of the autonomic nervous system, structural changes, myocardial fibrosis resulting in longer dispersion and/or repolarization time.…”

Section: Study Associationmentioning

confidence: 99%

Repolarização ventricular em pacientes diabéticos: caracterização e implicações clínicas

Clemente¹,

Pereira²,

Ribeiro³

2012

Arq. Bras. Cardiol.

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The association of the metabolic syndrome with QTc interval in NHANES III

Cited by 24 publications

References 34 publications

Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis

Repolarização ventricular em pacientes diabéticos: caracterização e implicações clínicas

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