The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke

Zhang, Ya Xin; Shen, Zhi Yuan; Jia, Yi Cun; Guo, Xin; Guo, Xiao Su; Xing, Yuan; Tian, Shu Juan

doi:10.2147/jir.s418106

Cited by 15 publications

(4 citation statements)

References 36 publications

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“…In addition, recent studies have shown that SIRI was associated with clinical outcomes in patients with stroke. 33,34 Furthermore, previous study showed that SIRI was an independent risk factor for mortality in patients with acute myocardial infarction. 35 In the present study, we found that patients with POD had higher NLR and SIRI before surgery.…”

Section: Discussionmentioning

confidence: 99%

The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study

Lu,

Lin,

Wang

et al. 2023

IJGM

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To explore the relationship between the systemic inflammation response index (SIRI) and postoperative delirium (POD) in older patients with hip arthroplasty surgery. Patients and Methods: Older patients who underwent elective hip arthroplasty surgery were included in this retrospective study. SIRI, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were collected from blood routine examination at admission. Binary logistic regression analysis was performed to evaluate the association between SIRI levels and POD was analyzed. Results: Ultimately, 116 older patients who met the inclusion criteria were assessed. Thirty-four (29%) of 116 patients diagnosed with POD were defined as the POD group, and the rest consisted of the Non-POD group. Compared with non-POD patients, POD patients showed significantly higher levels of SIRI (P < 0.001) and NLR (P = 0.002) at admission. There was no significance in the levels of PLR between two groups. SIRI was independently associated with the occurrence of POD in multivariate logistic regression analysis [odds ratio (OR) = 3.34, 95% confidence interval (95% CI) = 1.26-8.85, P = 0.016]. Receiver operating characteristic curve analysis indicated that SIRI with an optimal cutoff value of 0.987 predicted the POD with a sensitivity of 88.2% and specificity of 74.4%, and the area under the curve was 0.82 (95% CI, 0.74-0.90, P < 0.01). Conclusion:Preoperative SIRI and NLR levels in the blood are associated with the occurrence of POD. Moreover, preoperative SIRI level is a useful candidate biomarker to identify delirium after elective hip arthroplasty surgery in older patients.

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Section: Discussionmentioning

confidence: 99%

The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study

Lu,

Lin,

Wang

et al. 2023

IJGM

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“…Inflammatory markers including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), have been identified as emerging biomarkers that reflect the balance between innate immunity and adaptive immunity ( 11 ). These markers are used in prognosticating various conditions, such as cancer ( 12 , 13 ), cardiovascular diseases ( 14 ), acute ischemic strokes ( 15 , 16 ), and infectious diseases ( 17 ). The elevated NLR has been recognized as a noteworthy independent predictor for Parkinson’s disease (PD) ( 18 ), Alzheimer’s disease (AD) ( 19 , 20 ), and progressive supranuclear palsy (PSP) ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

The characteristic and prognostic role of blood inflammatory markers in patients with Huntington’s disease from China

Xia,

Cheng,

Zhang

et al. 2024

Front. Neurol.

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ObjectivesThis study aims to elucidate the role of peripheral inflammation in Huntington’s disease (HD) by examining the correlation of peripheral inflammatory markers with clinical manifestations and disease prognosis.MethodsThis investigation involved 92 HD patients and 92 matched healthy controls (HCs). We quantified various peripheral inflammatory markers and calculated their derived metrics including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). Clinical assessments spanning cognitive, motor, and disease severity were administered. Comparative analysis of inflammatory markers and clinical correlations between HD and controls was performed. Kaplan–Meier survival analysis and Cox regression model were used to assess the effect of inflammatory markers on survival.ResultsThe study revealed that HD patients had significantly reduced lymphocyte counts, and LMR. Conversely, NLR, PLR, and SII were elevated compared to HCs. Lymphocyte levels inversely correlated with the age of onset and monocyte levels inversely correlated with the UHDRS-total functional capacity (TFC) scores. After adjusting for age, sex, and CAG repeat length, lymphocyte count, NLR, PLR, and SII were significantly correlated with the progression rate of TFC scores. Elevated levels of white blood cells and monocytes were associated with an increased risk of disability and mortality in the HD cohort.ConclusionOur findings indicate that HD patients display a distinct peripheral inflammatory profile with increased NLR, PLR, and SII levels compared to HCs. The peripheral inflammation appears to be linked with accelerated disease progression and decreased survival in HD.

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“…Inflammatory markers including the neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), have been identified as emerging biomarkers that reflect the balance between innate immunity and adaptive immunity (11). These markers are used in prognosticating various conditions, such as cancer (12,13), cardiovascular diseases (14), acute ischemic strokes (15,16), and infectious diseases (17). The elevated NLR has been recognized as a noteworthy independent predictor for Parkinson's disease (PD) (18), Alzheimer's disease (AD) (19,20), and progressive supranuclear palsy (PSP) (21).…”

Section: Introductionmentioning

confidence: 99%

The characteristic and prognostic role of blood inflammatory markers in patients with Huntington's disease from China

Cheng,

Xia,

Shang

2024

Parkinsonism & Related Disorders

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The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke

Cited by 15 publications

References 36 publications

The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study

The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study

The characteristic and prognostic role of blood inflammatory markers in patients with Huntington’s disease from China

The characteristic and prognostic role of blood inflammatory markers in patients with Huntington's disease from China

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