The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Darand, Mina; Salehi‐Abargouei, Amin; Mehrjardi, Mohammad Yahya Vahidi; Feizi, Awat; Seyedhossaini, Seyed Mustafa; Askari, Gholamreza

doi:10.3389/fcvm.2022.1037940

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Similarly, the PON1 enzyme is found in circulating high-density lipoprotein (HDL) particles [ 44 ]. The Q192R PON1 polymorphism and the ε4 allele are both implicated in modifying the risk of cardiovascular disease, secondary to their role in lipid metabolism [ 45 – 47 ]. Therefore, it is possible that environmental toxicants, by interacting with these genes, may have modified lipid metabolism pathways that contribute to the pathogenesis of GWI.…”

Section: Discussionmentioning

confidence: 99%

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

et al. 2023

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Introduction Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI. Methods Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131). Diagnosis of GWI was performed using the Kansas and/or Center for Disease Control (CDC) criteria. Results Age- and sex-adjusted analyses showed a significantly higher odds ratio for meeting the GWI case criteria in the presence of the ε4 allele (Odds ratio [OR] = 1.84, 95% confidence interval [CI = 1.07–3.15], p ≤ 0.05) and with two copies of the ε4 allele (OR = 1.99, 95% CI [1.23–3.21], p ≤ 0.01). Combined exposure to pesticides and PB pills (OR = 4.10 [2.12–7.91], p ≤ 0.05) as well as chemical alarms and PB pills (OR = 3.30 [1.56–6.97] p ≤ 0.05) during the war were also associated with a higher odds ratio for meeting GWI case criteria. There was also an interaction between the ε4 allele and exposure to oil well fires (OR = 2.46, 95% CI [1.07–5.62], p ≤ 0.05) among those who met the GWI case criteria. Conclusion These findings suggest that the presence of the ε4 allele was associated with meeting the GWI case criteria. Gulf War veterans who reported exposure to oil well fires and have an ε4 allele were more likely to meet GWI case criteria. Long-term surveillance of veterans with GWI, particularly those with oil well fire exposure, is required to better assess the future risk of cognitive decline among this vulnerable population.

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Section: Discussionmentioning

confidence: 99%

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

et al. 2023

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“…Interestingly, the apolipoprotein E (apoE) protein is involved in lipid transport, and the ε4 allele lowers apoE availability within HDL particles. Since this PON1 polymorphism and the ε4 allele are both implicated in modifying the risk of cardiovascular disease, secondary to their role in lipid metabolism [42][43][44], it is, therefore, possible that environmental toxicants may modify lipid metabolism pathways that contribute to the pathogenesis of GWI. In that regard, our prior studies have shown increased triglycerides in the blood of veterans with GWI [30].…”

Section: Discussionmentioning

confidence: 99%

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosis

Abdullah

Nkiliza

Niedospial

et al. 2023

Preprint

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Introduction: Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI. Methods: Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131). Diagnosis of GWI was performed using the Kansas and/or Center for Disease Control (CDC) criteria. Results: Age- and sex-adjusted analyses showed a significantly higher odds ratio for meeting the GWI case criteria in the presence of the ε4 allele (Odds ratio [OR] = 1.84, 95% confidence interval [CI = 1.07 – 3.15], p ≤ 0.05) and with two copies of the ε4 allele (OR = 1.99, 95% CI [1.23 - 3.21], p ≤ 0.01). Combined exposure to pesticides and PB pills (OR = 4.10 [2.12-7.91], p ≤ 0.05) as well as chemical alarms and PB pills (OR = 3.30 [1.56-6.97] p ≤ 0.05) during the war were also associated with a higher odds ratio for meeting GWI case criteria. There was also an interaction between the ε4 allele and exposure to oil well fires (OR = 2.46, 95% CI [1.07-5.62], p ≤ 0.05) among those who met the GWI case criteria. Conclusion: These findings suggest that the presence of the ε4 allele was associated with meeting the GWI case criteria. Gulf War veterans who reported exposure to oil well fires and have an ε4 allele were more likely to meet GWI case criteria. Long-term surveillance of veterans with GWI, particularly those with oil well fire exposure, is required to better assess the future risk of cognitive decline among this vulnerable population.

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Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians

Abdelaziz,

Mesbah,

Abo-Elmatty

et al. 2024

Archives of Physiology and Biochemistry

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The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Cited by 4 publications

References 49 publications

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosis

Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians

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