The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis

Li, Dan; Li, Jin; Li, Chunlei; Chen, Qianming; Hua, Hong

doi:10.3389/fendo.2017.00310

Cited by 37 publications

(32 citation statements)

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“…The third major group of oral white lesions is white keratotic lesions with a specific pattern (Table 3), which can be differentiated from other entities by their special clinical features like discrete papules, annular or reticular forms; however, they are not distinguishable from each other nor clinically neither microscopically. This group comprises of lichenoid reactions (oral lichen planus, lichenoid contact reaction, drug-induced lichenoid reaction, graft versus host disease) [27,28,29,30]. Presence of papules or reticular elements with symmetrical and generalized distribution along with skin or extraoral mucosal (genitalia) involvement would be in favor of lichen planus [4,30].…”

Section: Discussionmentioning

confidence: 99%

“…Significantly increased amounts of serum anti-thyroglobulin, autoantibodies and anti-thyroid microsomal autoantibodies were found in these patients. The prevalence of thyroid disease in patients with OLP has been reported 2.19% to 6.46% [28]. Moreover, OLP has been found to have a major correlation with diabetes mellitus (DM), which might be due to endocrine dysfunction and immunological defects.…”

Section: Acquired Lesions That Cannot Be Scraped Off (With Specifimentioning

confidence: 99%

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Oral White Lesions: An Updated Clinical Diagnostic Decision Tree

et al. 2019

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Diagnosis of oral white lesions might be quite challenging. This review article aimed to introduce a decision tree for oral white lesions according to their clinical features. General search engines and specialized databases including PubMed, PubMed Central, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as “mouth disease”, “oral keratosis”, “oral leukokeratosis”, and “oral leukoplakia”. Related English-language articles published since 2000 to 2017, including reviews, meta-analyses, and original papers (randomized or nonrandomized clinical trials; prospective or retrospective cohort studies), case reports, and case series about oral diseases were appraised. Upon compilation of data, oral white lesions were categorized into two major groups according to their nature of development: Congenital or acquired lesions and four subgroups: Lesions which can be scraped off or not and lesions with the special pattern or not. In total, more than 20 entities were organized in the form of a decision tree in order to help clinicians establish a logical diagnosis by a stepwise progression method.

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Section: Discussionmentioning

confidence: 99%

Section: Acquired Lesions That Cannot Be Scraped Off (With Specifimentioning

confidence: 99%

Oral White Lesions: An Updated Clinical Diagnostic Decision Tree

et al. 2019

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“…Of these, thyroid disease has gained an increasing interest in this field more recently. A meta-analysis has been conducted by our team and reported a close relationship between thyroid disease and OLP in many countries ( 9 ). However, the situation in Chinese patients is lacking evidence, hence the study concept presented here.…”

Section: Discussionmentioning

confidence: 99%

“…Various factors such as genetic predisposition, psychological factors, and infectious precipitants may be involved in the development of OLP ( 5 , 6 ). Moreover, some systemic diseases such as hypertension, diabetes, and thyroid disorders may increase the risk of OLP ( 7 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study

Zhou

Chen

et al. 2018

Front. Endocrinol.

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BackgroundA possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.ObjectiveThis study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.Methods192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case–control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto’s thyroiditis (HT), hypothyroidism, and thyroid nodule].ResultsThe prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87–5.33) for OLP, 2.09 (1.18–3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30–4.09) for OLP.ConclusionOur study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.

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“…Since OLP is considered by some as an immune-mediated disease, it is reasonable to assume that it may be associated with other immune-mediated diseases, including autoimmune TGDs [10–12]. The prevalence of TGDs in OLP patients ranges between 6.2 to 15.3% compared to a lower prevalence of 1.6–8% in control groups, with odds ratio ranging between 1.47 and 3.01 [13]. A more recent investigation reported a prevalence of 72.4% of TGDs in OLP patients and of 49.4% in controls [14].…”

Section: Introductionmentioning

confidence: 99%

Oral lichen planus and thyroid gland diseases: possible associations

et al. 2019

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Background Lichen planus (LP) is a chronic inflammatory mucocutaneous disease that commonly affects the oral cavity. Previous reports have suggested a possible association between LP and thyroid gland diseases (TGDs). The purpose of this study was to investigate possible associations between oral lichen planus (OLP) and TGDs. Methods Patients diagnosed with OLP, both clinically and histopathologically ( N = 102), were classified according to clinical course (symptomatic/asymptomatic), type (reticular/plaque, atrophic and erosive) and location of lesions. Data on TGDs was compared to age- and gender-matched controls ( N = 102) without OLP. Diagnosis of any type of TGD and related medication for study and control groups was recorded from the medical files provided by patients’ physicians. Statistical analysis used Student’s t-test and Fisher’s exact test; significance was set at p < 0.05. Results TGDs (all), hypothyroidism and related medications were found in 16.6, 12.7 and 12.7% of patients with OLP, respectively. These findings were similar to the control group: TGDs (all) -15.7%, hypothyroidism - 9.8% and thyroid gland disease-related medication - 9.8% ( p > 0.05). No significant associations were found between different characteristics of OLP and hypothyroidism or other TGD ( p > 0.05). Conclusions We found no significant associations between the co-existence of OLP and TGD or related-medications. Our findings are in agreement with some of the previously published similar studies but in controversy with others. Further well-designed, multicenter studies with large groups of patients and controls may help to establish the nature of the associations between OLP and TGDs.

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The Association of Thyroid Disease and Oral Lichen Planus: A Literature Review and Meta-analysis

Cited by 37 publications

References 29 publications

Oral White Lesions: An Updated Clinical Diagnostic Decision Tree

Oral White Lesions: An Updated Clinical Diagnostic Decision Tree

Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study

Oral lichen planus and thyroid gland diseases: possible associations

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