The Association of TMPRSS6 Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia

Abstract

Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in genome-wide association studies, but their effect in young children where anemia and iron deficiency (ID) were prevalent has not been reported, particularly taking account of iron intake. This study aims to investigate whether TMPRSS6 SNPs (rs855791 and rs4820268) and iron intake are associated with a low iron and hemoglobin concentration in under-two-year-old children. The study analyzed the baseline of a randomized trial (NUPICO, ClinicalTrials.gov NCT01504633) in East Lombok, Indonesia. Children aged 6–17 months (n = 121) were included in this study. The multiple linear regressions showed that TMPRSS6 decreased serum ferritin (SF) by 4.50 g/L per copy minor allele (A) of rs855791 (p = 0.08) and by 5.00 μg/L per copy minor allele (G) of rs4820268 (p = 0.044). There were no associations between rs855791 and rs4820268 with soluble transferrin receptor (sTfR) and hemoglobin (Hb) concentration (rs855791; p = 0.38 and p = 0.13, rs4820268; p = 0.17 and p = 0.33). The finding suggests the need for further studies to explore whether the nutrient recommendation for iron should be based on genetic characteristics, particularly for children who have mutation in TMPRSS6.

Family Characteristics and Anemia in Relation to Preference and Food Variety in Infant Complementary Food

“…The prevalence of anemia in infants 6-10 months in this study was 93.9%, almost the same with research in Sasak in 6-17 months infants (92.6%). Higher than study in Bantul, Yogyakarta in 6 months (75.3%) [18], or in 8-12 infants months in Jakarta (73.3%) [19]. Research in rural China shows an even lower prevalence (43.5%) in infants with a wider age range of 6-30 months [20], in line with the WHO stated global anemia prevalence was 47.4% for pre-school children [21].…”

TMPRSS6 gene polymorphisms associated with iron deficiency anaemia among global population

“…Shinta and colleagues discovered a link between the TMPRSS6 gene polymorphism and iron intake/iron status in under-two-year-old toddlers in Lombok, Indonesia. All of these findings support the direct link between TMPRSS6 gene mutations and IDA, as well as several clinical characteristics [46]. As previously identified that rs855791 and rs4820268 as the common variants associated with low iron and blood parameters among other populations.…”

“…Most studies on TMPRSS6 SNPs that influence biochemical parameters were conducted in Caucasians, and fewer studies were run among the Asian population [46][47][48][49][50][51][52]. However, multiple TMPRSS6 SNPs have been identified across all studies, profoundly associated with IRIDA, IDA, low iron, and blood indices.…”

“…Both SNPs were also frequently identified among the children with IDA rs855791 and rs4820268, exhibiting significant association with low serum ferritin. However, no other associations were found between sTfR and Hb [46]. Gichohi-Wainaina et al [59] reported that the minor allele frequency (MAF) of rs855791 is higher Mohd Atan et al Egyptian Journal of Medical Human Genetics (2022) 23:147 in the Asian population than in the Caucasian.…”

Maternal <i>TMPRSS6</i> Gene Polymorphism rs855791SNP in Women with Preeclampsia

“…Recently, the Genome-Wide Association (GWA) studies identified several Single Nucleotide Polymorphisms (SNPs) of the TMPRSS6 genes, and it was found that the rs855791 has strong robust relation with microcytic red blood cell phenotype [28]. The SNP occurs at nucleotide position 2207 of TMPRSS6 exon 17, causing a missense mutation from Valine (V) to Alanine (A) as GTC > GCC; V736A [29].…”