2019
DOI: 10.1136/bmjopen-2018-025336
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The association of tryptophan and phenylalanine are associated with arsenic-induced skin lesions in a Chinese population chronically exposed to arsenic via drinking water: a case–control study

Abstract: ObjectivesWe investigated the association of specific serum amino acids (AAs) with the odds of arsenic-induced skin lesions (AISL) and their ability to distinguish patients with AISL from people chronically exposed to arsenic.DesignCase–control study.SettingThree arsenic-exposed villages in Wuyuan County, Hetao Plain, Inner Mongolia, China were evaluated.ParticipantsAmong the 450 residents aged 18–79 years, who were chronically exposed to arsenic via drinking water, 56 were diagnosed as having AISL (defined as… Show more

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Cited by 10 publications
(5 citation statements)
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“…So far, the research on the effects of n-6 PUFAs on human diabetic retinopathy is very rare, and their relationship is not yet clear. To address these critical knowledge gaps, we aimed to comprehensively investigate the association between n-6 PUFAs levels and DR based on a widelytargeted metabolomics approach, which had been popularly accepted as an useful way to identify a specific disease early and better understand the related pathogenesis depending on the unbiased monitoring of changes in endogenous metabolism-related physiological processes ( 20 ).…”
Section: Introductionmentioning
confidence: 99%
“…So far, the research on the effects of n-6 PUFAs on human diabetic retinopathy is very rare, and their relationship is not yet clear. To address these critical knowledge gaps, we aimed to comprehensively investigate the association between n-6 PUFAs levels and DR based on a widelytargeted metabolomics approach, which had been popularly accepted as an useful way to identify a specific disease early and better understand the related pathogenesis depending on the unbiased monitoring of changes in endogenous metabolism-related physiological processes ( 20 ).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, such amino acids alone were reported to be a potential tool for distinguishing patients developing skin lesions after arsenic exposure from healthy controls, therefore potentially being used as early disease markers [ 98 ].…”
Section: Resultsmentioning
confidence: 99%
“…5-hydroxy-L-tryptophan is a metabolite of L-tryptophan. In a Chinese population exposed to arsenic, the signal intensity of tryptophan in the serum was negatively associated with arsenic-induced skin lesions (AISL), and a higher level of tryptophan showed the lowest odds of AISL [ 57 ]. iAs exposure in MIN6-K8 cells decreased the signal intensity of serotonin and its precursor, 5-hydroxy-L-tryptophan, along with a decrease in glucose-stimulated insulin secretion (GSIS).…”
Section: Discussionmentioning
confidence: 99%