The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population

Petrović, Sanja Matić; Nikolic, Nadja; Toljic, Bosko; Jovanović, Jelena Arambašić; Miličić, Biljana; Miličić, Tanja; Jotić, Aleksandra; Vidaković, Melita; Milašin, Jelena; Pucar, Ana

doi:10.1016/j.archoralbio.2020.104929

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Therefore, the development of periodontitis in T2DM may be related to pathological alterations in the periodontium caused by diabetes due to hyperglycemia, high AGE levels and oxidative stress. T2DM is suggested to mask the impact of periodontitis on systemic inflammation [58].…”

Section: Aggression Recognitionmentioning

confidence: 99%

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Portes

Bullón

Quiles

et al. 2021

Cells

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Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success.

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Section: Aggression Recognitionmentioning

confidence: 99%

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Portes

Bullón

Quiles

et al. 2021

Cells

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“…), and abnormal host response to periodontal disease are the key determinants of the onset and progression of periodontal disease [3]. In recent years, special attention has been paid to the possibility that the presence of periopathogens may influence systemic health [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Identification of Periopathogens in Atheromatous Plaques Obtained from Carotid and Coronary Arteries

Pavlić

Perić²,

Kalezic³

et al. 2021

BioMed Research International

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Increasing attention has been paid to the possible link between periodontal disease and atherosclerosis over the past decade. The aim of this study is to investigate the presence of five periopathogens: Porphyromonas gingivalis (P.g.), Aggregatibacter actinomycetemcomitans (A.a.), Tannerella forsythia (T.f.), Treponema denticola (T.d.), and Prevotella intermedia (P.i.) in atheromatous plaques obtained from the carotid and coronary arteries in patients who underwent coronary artery bypass graft surgery and carotid endarterectomy. Group I (carotid arteries) consisted of 30 patients (mean age: 54.5 ± 14.8 ), and group II (coronary arteries) consisted of 28 patients (mean age: 63 ± 12.1 ). Clinical periodontal examinations consisted of plaque index, gingival index, sulcus bleeding index, and periodontal probing depth and were performed on the day of vascular surgery. The presence of periopathogens in periodontal pockets and atherosclerotic vessels was detected using polymerase chain reaction. In both subgingival plaque and atherosclerotic plaque of carotid arteries, P.g., A.a., T.f., T.d., and P.i. were detected in 26.7%, 6.7%, 66.7%, 10.0%, and 20.0%, respectively, while for coronary arteries, P.g. was detected in 39.3%, A.a. in 25%, T.f. in 46.4%, T.d. in 7.1%, and P.i. in 35.7%. The presence of five periopathogens in carotid and coronary atherosclerotic vessels showed correlation in regard to the degree of periodontal inflammation. The present study suggests the relationship between periodontal pathogenic bacteria and atherogenesis. Further studies are necessary in relation to the prevention or treatment of periodontal disease that would result in reduced mortality and morbidity associated with atherosclerosis.

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Association between Periodontitis and Genetic Polymorphisms in Interleukins among Patients with Diabetes Mellitus

et al. 2021

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There is a perplexity in the association between interleukin (IL) polymorphisms and periodontitis among patients with and without diabetes mellitus (DM). The aim of the present study was to evaluate indexed data regarding the association between periodontitis and genetic polymorphisms in interleukins among patients with and without DM. The addressed question was “Is there an association between periodontitis and polymorphisms in interleukins among patients with and without DM?” Original studies were included. Indexed databases were searched, and the pattern of the present literature review was customized to summaries’ the pertinent information. Eight studies were included and processed for data extraction. Two studies showed that polymorphisms in IL-1B genes aggravate periodontitis in patients with type-2 DM, and two studies showed that IL-1B genes either do not or are less likely to contribute towards the progression of periodontitis in patients with type-2 DM. Two studies reported that IL genes do not show cross-susceptibility with periodontitis and type-2 DM. One study reported that the primary factor that governs the occurrence and progression of periodontitis in patients with and without type-2 DM is poor routine oral hygiene maintenance. Seven studies had a high risk of bias. The role of IL gene polymorphisms in the development and progression of periodontitis in patients with and without DM remains controversial.

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The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population

Cited by 3 publications

References 67 publications

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Identification of Periopathogens in Atheromatous Plaques Obtained from Carotid and Coronary Arteries

Association between Periodontitis and Genetic Polymorphisms in Interleukins among Patients with Diabetes Mellitus

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