The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

Shiraki, Masataka; Kashiwabara, Shoji; Imai, Takumi; Tanaka, Shiro; Saito, Mitsuru

doi:10.1007/s00774-019-01017-9

Cited by 24 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(53) In the Health ABC cohort, the urinary AGE pentosidine was associated with increased incidence of clinical fractures (HR 1.42; 95% CI, 1.10 to 1.83; for 1 SD increase in log pentosidine) and increased prevalence of vertebral fractures (adjusted odds ratio, 5.93; 95% CI, 2.08 to 16.94; for 1 SD increase in log pentosidine) in subjects with T2D, but not in those without diabetes. (54) Urinary pentosidine dosage has been inconsistently associated with fracture risk in other studies (54)(55)(56)(57) ; therefore, direct quantification of bone AGE content remains the gold standard, although not feasible in large cohorts.…”

Section: Discussionmentioning

confidence: 99%

Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

Napoli

Conte

Eastell

et al. 2020

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Type 2 diabetes (T2D) is characterized by increased fracture risk despite higher BMD and reduced bone turnover. BMD underestimates fracture risk in T2D, but the predictive role of bone turnover markers (BTMs) on fracture risk in T2D has not been explored. Thus, we sought to determine whether BTMs predict incident fractures in subjects with T2D. For this case‐cohort study, we used data from the Health, Aging, and Body Composition (Health ABC) Study of well‐functioning older adults, aged 70 to 79 years at baseline (April 1997–June 1998). The case‐cohort sample consisted of (i) the cases, composed of all 223 participants who experienced incident fractures of the hip, clinical spine, or distal forearm within the first 9 years of study follow‐up; and (ii) the subcohort of 508 randomly sampled participants from three strata at baseline (T2D, prediabetes, and normoglycemia) from the entire Health ABC cohort. A total of 690 subjects (223 cases, of whom 41 were in the subcohort) were included in analyses. BTMs (C‐terminal telopeptide of type I collagen [CTX], osteocalcin [OC], and procollagen type 1 N‐terminal propeptide [P1NP]) were measured in archived baseline serum. Cox regression with robust variance estimation was used to estimate the adjusted hazard ratio (HR) for fracture per 20% increase in BTMs. In nondiabetes (prediabetes plus normoglycemia), fracture risk was increased with higher CTX (HR 1.10; 95% confidence interval [CI], 1.01 to 1.20 for each 20% increase in CTX). Risk was not increased in T2D (HR 0.92; 95% CI, 0.81 to 1.04; p for interaction .045). Similarly, both OC and P1NP were associated with higher risk of fracture in nondiabetes, but not in T2D, with p for interaction of .078 and .109, respectively. In conclusion, BTMs did not predict incident fracture risk in T2D but were modestly associated with fracture risk in nondiabetes. © 2020 American Society for Bone and Mineral Research.

show abstract

Section: Discussionmentioning

confidence: 99%

Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

Napoli

Conte

Eastell

et al. 2020

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Routine biochemical data were obtained by respective in-house laboratories. Urinary PEN level was determined by an ELISA method 6,18 without the need for sample pre-treatment with heat hydrolysis; this method was preferred over PEN measurement in serum samples, which would have required heat hydrolysis and possible inclusion of artificial error. The assay performance of this ELISA system for urinary PEN was reported previously 18 .…”

mentioning

confidence: 99%

Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers

Nakano

Nakamura

Suzuki

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis and osteoporotic fractures remains controversial. This cross-sectional study aimed to investigate the associations of PEN and CML with bone markers, bone mineral density (BMD), and osteoporotic fractures in postmenopausal women from the Nagano Cohort Study. A total of 444 Japanese postmenopausal outpatients (mean ± standard deviation age: 69.8 ± 10.2 years) were enrolled after the exclusion of patients with acute or severe illness or secondary osteoporosis. The relationships among urinary PEN and serum CML levels, various bone markers, lumbar and hip BMD, and prevalent vertebral and long-bone fractures were evaluated. PEN associated significantly with prevalent vertebral fracture after adjustment for other confounders (odds ratio [OR] 1.59, 95% confidence interval [CI] 1.22–2.07; P < 0.001), but not with lumbar BMD. In contrast, a significant negative correlation was found between CML and lumbar BMD (r = − 0.180; P < 0.001), and this relationship was significant after adjustment for confounders (OR 0.84, 95% CI 0.76–0.93; P < 0.01). Although patients with prevalent vertebral fracture had significantly higher CML levels, the association between CML and prevalent vertebral fracture did not reach significance in the multivariate regression model. Both PEN and CML may play important roles in bone health for postmenopausal women, possibly via different mechanisms.

show abstract

“…However, bone quality, in term of tissue material properties, has not been investigated in patients with CLD. Among several risk factors for fractures, prevalent fractures are especially significant in predicting the occurrence of further fragility fractures [17]. Therefore, the present study focused on bone quality and aimed to clarify its involvement in prevalent fractures among patients with CLD.…”

Section: Discussionmentioning

confidence: 99%

“…Prevalent fragility fractures were defined as a history of fractures of the vertebra, proximal portion of the humerus and femur, distal portion of the radius, lower extremity, rib, or pelvis, which occurred after the age of 40 years [17]. Prevalent vertebral fractures, including asymptomatic fractures diagnosed only by radiography, were semi-quantitatively assessed using lateral thoracolumbar spine radiographs [25].…”

Section: Fracture Assessmentmentioning

confidence: 99%

“…Pentosidine is a surrogate marker for AGEs that accumulate in bone due to advanced age or diseases, such as chronic kidney disease (CKD) and diabetes [12][13][14][15][16]. Indeed, high levels of serum and urinary pentosidine are independent factors for osteoporotic fractures in patients with diabetes and postmenopausal women [17][18][19][20]. Thus, pentosidine is a useful marker for appraising fracture risk in these diseases/conditions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease

et al. 2021

Self Cite

View full text Add to dashboard Cite

Aim Osteoporotic fractures negatively impact health-related quality of life and prognosis. Advanced glycation end products (AGEs) impair bone quality and reduce bone strength. The aim of this study was to determine the relationship between plasma levels of pentosidine, a surrogate marker for AGEs, and prevalent fractures in patients with chronic liver disease (CLD). Methods This cross-sectional study included 324 patients with CLD. Vertebral fractures were evaluated using lateral thoracolumbar spine radiographs. Information on prevalent fractures was obtained through a medical interview, medical records, and/or radiography. The patients were classified into low (L), intermediate (I), and high (H) pentosidine (Pen) groups based on baseline plasma pentosidine levels. Results Of the 324 patients, 105 (32.4%) had prevalent fractures. The prevalence of liver cirrhosis (LC) and prevalent fractures significantly increased stepwise with elevated pentosidine levels. The H-Pen group had the highest prevalence of LC (88.6%, p < 0.001) and prevalent fractures (44.3%, p = 0.007), whereas the L-Pen group had the lowest prevalence of LC (32.1%, p < 0.001) and prevalent fractures (21.0%, p = 0.007). Multiple logistic regression analysis identified pentosidine as a significant independent factor related to prevalent fractures (odds ratio = 1.069, p < 0.001). Pentosidine levels increased stepwise and correlated with liver disease severity. They were markedly high in patients with decompensated LC. In multiple regression analysis, liver functional reserve factors (total bilirubin, albumin, and prothrombin time-international normalized ratio) significantly and independently correlated with pentosidine levels. Conclusions Plasma pentosidine was significantly associated with prevalent fractures and liver functional reserve in patients with CLD. Pentosidine may be useful in predicting fracture risk and should be closely followed in CLD patients with advanced disease.

show abstract

The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

Cited by 24 publications

References 21 publications

Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers

Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease

Contact Info

Product

Resources

About