The association of vitamin D, cathelicidin, and vitamin D binding protein with acute asthma attacks in children

Arıkoğlu, Tuğba; Kuyucu, Semanur; Karaismailoğlu, Eda; Batmaz, Sehra Birgül; Balcı, Şenay

doi:10.2500/aap.2015.36.3848

Cited by 30 publications

(31 citation statements)

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“…Some case-controlled studies could show the association between vitamin D deficiency and asthma in children. In a study by Arikoglu et al [15], the association between vitamin D deficiency and increased risk for asthmatic attack in children was indicated. In this regard, the mean serum level of vitamin D in the asthma attack group was significantly lower than that of the controlled asthma group.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and its impact on asthma severity in asthmatic children

et al. 2016

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BackgroundDespite obtaining evidences on association between vitamin D and development of lung in fetus, little is known about vitamin D level and its impact on severity of asthma in children. The present study aimed to assess the relationship between the asthma severity and vitamin D deficiency in asthmatic children.MethodsThis case-control study was conducted on 106 individuals including asthmatic (n = 53) and healthy children (n = 53) who referred to Mofid hospital in Tehran in 2013. The level of serum vitamin D in both groups was measured by radioimmunoassay method at the reference lab and was categorized as sufficient (> 30 ng/ml), insufficient (20 to 30 ng/ml), or deficient (< 20 ng/ml). The control status of asthma in patients group was classified as controlled, partially controlled, and uncontrolled.ResultsIn the groups with and without asthma, the prevalence of vitamin D deficiency was 73.6 and 49.1%, and the prevalence of vitamin D insufficiency was 18.9 and 18.9%, while normal vitamin D level was revealed in 7.5 and 32.1%, respectively with a significant difference (p = 0.005). Using the multivariate logistic regression analysis, the presence of asthma was associated with reduced level of vitamin D (OR = 1.068, 95% CI: 1.027–1.110, P = 0.001). In this context, the risk for asthma in the children with vitamin D deficiency was 6.3 times of those with normal vitamin D level. Although the presence of asthma was strongly associated with reduced level of vitamin D in serum, neither severity of asthma nor control status of asthma were associated with vitamin D deficiency.ConclusionThe presence of vitamin D deficiency effectively predict increased risk for childhood asthma; however the severity or control status of this event may not be predicted by confirming vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and its impact on asthma severity in asthmatic children

et al. 2016

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“…In a recent analysis, vitamin D deficiency was associated with low lung function among obese children with asthma, but not among those of normal weight 58 . Another recent study reported that high BMI was associated with asthma exacerbations among children with low vitamin D, with cathelicidin (an innate immunity polypeptide found in macrophages and neutrophils) potentially playing a mediating role 59 . Omega-3 and omega-6 fatty acids have also been linked to asthma 60 , and fish oil supplementation in early life has been reported to modulate immune responses 61 .…”

Section: Diet and Nutrientsmentioning

confidence: 99%

The effect of obesity, weight gain, and weight loss on asthma inception and control

Forno

Celedón

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of the review There is ample and growing evidence that obesity increases the risk of asthma and morbidity from asthma. Here we review recent clinical evidence supporting a causal link between obesity and asthma, and the mechanisms that may lead to “obese asthma”. Recent findings While in some children obesity and asthma simply co-occur, those with “obese asthma” have increased asthma severity, lower quality of life, and reduced medication response. Underlying mechanistic pathways may include anatomical changes of the airways such as obstruction and dysanapsis; systemic inflammation; production of adipokines; impaired glucose-insulin metabolism; altered nutrient levels; genetic and epigenetic changes; and alterations in the airway and/or gut microbiome. A few small studies have shown that weight loss interventions may lead to improvements in asthma outcomes, but thus far research on therapeutic interventions for these children has been limited. Summary Obesity increases the risk of asthma –and worsens asthma severity or control– via multiple mechanisms. “Obese asthma” is a complex, multifactorial phenotype in children. Obesity and its complications must be managed as part of the treatment of asthma in obese children.

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“…Vitamin D deficiency is a condition that is still being reported at quite high rates all over the world, including developed countries, and it can lead to serious health problems (21). In our study, it was detected that while duration of VD intake is the only factor affecting the serum VD level, insufficient serum VD level is a risk factor related to wheezing.…”

Section: Discussionmentioning

confidence: 57%

The Relationship Between Vitamin D Deficiency and Wheezing in Young Children; A Randomized Study

Mansuroğlu

Altıntaş

Doğruel

2017

Asthma Allergy Immunol

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ÖZGiriş: D vitamini (VD) immünolojik süreçlerde kritik bir rol oynamaktadır ve çeşitli allerjik ve enfeksiyöz hastalıkların gelişimindeki rolünü araştırmak için çalışmalar yürütülmektedir. Çalışmanın amacı, çocuklarda 25(OH)D düzeyini etkileyen faktörleri belirlemek ve VD ile vizing, allerji ve enfeksiyonlar arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem:Çalışmaya, 18-24 ay arasında 64 çocuk dahil edildi. Çalışmanın başında ve sonunda fizik muayene yapıldı, kan örnekleri alındı ve aileler bir anket doldurdu. İlk vizitte çocukların yarısına 400 ünite VD desteği önerildi. Çalışmanın 3., 6. ve 12. aylarında takip vizitleri planlandı. ABSTRACTObjective: Vitamin D (VD) plays a critical role in immunological processes and studies have been conducted to investigate its role in the development of several allergic and infectious diseases. The aim of this study was to determine the factors that affect the 25(OH)D level in children, and also to assess the relationship between VD and wheezing, allergy, and infection. Materials and Methods:Sixty-four children between 18-24 months of age were included in this study. At the beginning and at the end of the study, a physical examination was performed, blood samples were taken, and parents completed the questionnaire. Half of the children had been recommended at the first visit to take daily 400 units of VD. Follow-up visits were scheduled at the 3rd, 6th and 12th months of the study. Results:The mean age of the infants participating in the study was 20.3±1.5 months. 46.9% (n=30) of the infants were female and 53.1% (n=34) were male. While the 25(OH)D level was 29.8±10.8 ng/ml at the beginning of the study, it was 26.5±10.3 ng/ml (p=0.017) at the end of the study. The percentage of patients with sufficient 25 (OH) D levels was 48.4% (n = 31) at the beginning of the study and 29.7% (n = 19) at the end of the study (p=0.010). A statistically significant relationship was determined between VD intake and serum 25(OH)D level. At the beginning and at the end of the study, the 25(OH)D level was statistically inversely correlated with wheezing. Low 25(OH)D levels were also found to be a risk factor for the development of wheezing. No statistically significant relationship was determined between the serum 25(OH)D level and allergic and respiratory outcomes. Conclusion:When the factors which effect 25(OH)D level were examined, it was only associated with VD supplementation. VD deficiency showed a significant relationship with wheezing development, regardless of supplementation of VD.

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The association of vitamin D, cathelicidin, and vitamin D binding protein with acute asthma attacks in children

Abstract: Vit D deficiency showed a significant relationship to the development of asthma attacks independent of cathelicidin deficiency and other factors associated with the severity of chronic asthma.

Cited by 30 publications

References 0 publications

Vitamin D deficiency and its impact on asthma severity in asthmatic children

Vitamin D deficiency and its impact on asthma severity in asthmatic children

The effect of obesity, weight gain, and weight loss on asthma inception and control

The Relationship Between Vitamin D Deficiency and Wheezing in Young Children; A Randomized Study

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