The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis

Yu, Zhihong; Chen, Miao; Zhang, Qingqian; Hu, Xun

doi:10.2174/1386207322666190125150557

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…The results showed that Bsm1 and Cdx2 polymorphisms were protective factors for avoiding lung cancer incidence, while T allele and TT genotype of Taq1 were risk factors for lung cancer susceptibility. Our results were partly consistent with previous meta-analysis studies conducted by Yu et al (2018), which indicated that the Bsm1 A allele was negatively related to the lung cancer risk and the T allele carriers were at increased risk of lung cancer, and by Li et al (2019), which suggested that Bsm1, Taq1, and Cdx-2 polymorphisms may contribute to lung cancer susceptibility.…”

Section: Discussionsupporting

confidence: 92%

The Association BetweenVDRandGCPolymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Duan

Zheng

et al. 2020

Genetic Testing and Molecular Biomarkers

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Background: Lung cancer is the leading cause of cancer-related deaths worldwide, imposing an enormous economic burden on society. Several studies have identified a link between the genetic polymorphisms in vitamin D pathways and lung cancer risk; however, the results remain inconclusive. The aim of this study was to estimate the effect of polymorphisms in the vitamin D receptor (VDR) and GC genes on lung cancer risk. Methods: Eligible case-control studies published between January 2000 and December 2018 were searched and studied. The pooled odds ratio and its 95% confidence interval were used to estimate the effect. Results: Fifteen articles that included 4732 lung cancer patients and 4337 controls were identified for this study. Our results demonstrated that the VDR Bsm1 polymorphism (p < 0.05) and the TC and TT+TC genotypes of the Cdx2 polymorphism (p < 0.05) were protective factors for avoiding lung cancer incidence, while the T allele and the TT genotype of Taq1 polymorphism (p < 0.05) were risk factors for lung cancer. Ethnicity-based subgroup analyses indicated that the AA genotype of both the Apa1 and the Bsm1 polymorphisms decreased lung cancer risk in Asians, while Fok1 and Taq1 polymorphisms increased lung cancer risk in Asians. Subgroup analysis by cancer subtypes showed that certain alleles and genotypic structures of the Bsm1, Fok1, Taq1, and rs7041 were associated with nonsmall-cell lung cancer risk. Subgroup analysis by smoking status showed that the interaction between the TT genotype of Taq1 and smoking increased the risk of lung cancer. Subgroup analysis with regard to gender showed that the AA+Aa genotype of Apa1 decreased lung cancer risk in male patients. Conclusions: Our results suggest that the Bsm1 and Cdx2 polymorphisms decreased lung cancer risk, while the Taq1 polymorphism increased lung cancer risk. Moreover, the AA genotype of the Apa1 and Bsm1 variants were protective factors in Asian populations, whereas the Fok1 and Taq1 polymorphisms were risk factors for lung cancer in Asian populations. Future case-control studies with different ethnicities are still needed to generalize these associations.

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Section: Discussionsupporting

confidence: 92%

The Association BetweenVDRandGCPolymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Duan

Zheng

et al. 2020

Genetic Testing and Molecular Biomarkers

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“…To the best of our knowledge, just 3 previous researches have investigated the effect of VDR genetic polymorphism in relation to LC risk. [39][40][41] In this present study, we identified 3 locus in VDR genes have significant association with LC. Currently, compared with the previous, there are various advantages in our study, more gene loci were included in analysis, especially to Cdx-2, which is the first gene loci included in this meta-analysis, more databases were retrieved (Pubmed, PMC, Embase, Cochrane library, Web of Science and CNKI), more studies with better quality were selected for analysis, the relationship between polymorphism of candidate gene locus and lung cancer susceptibility was analyzed under 5 genetic models, stratified analysis was further conducted by ethnicity and larger sample size increased the statistical capacity.…”

Section: Discussionsupporting

confidence: 55%

“…In this meta-analysis, we comprehensively assessed 4 candidate SNPs (Bsm1, Apa1, Taq1, Cdx-2) of VDR gene for association with LC susceptibility from 9 selected studies, and we found many differences between the results of this study and previous studies. [39][40][41] Previous studies have shown that Apa1 and Bsm1 were associated with LC risk in overall populations, Caucasians and Asians in some genetic models. However, according to our study, all genetic models of Apa1 failed to find correlation with LC incidence both in overall and stratified analysis, no association was found between Bsm1 and susceptibility to LC in Caucasians although it could reduce the risk of LC in overall populations and Asians under all 5 genetic models.…”

Section: Discussionmentioning

confidence: 99%

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis

Li¹,

Liu²,

Liu³

et al. 2019

J. Cancer

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Purpose: The aim of this meta-analysis was to investigate polymorphism of Bsm1, Apal, Taq1 and Cdx-2 in vitamin D receptor (VDR) associations in relation to lung cancer (LC) susceptibility. Methods: 9 literatures were recruited into this meta-analysis from PubMed, PMC, Embase, Web of Science, Cochrane library and CNKI. STATA version 15.1 was used for statistical tests. The heterogeneity was tested using I 2 statistics. According to the value of I 2 , the random-effect model (REM) or fixed-effect model (FEM) was selected to combine data from studies, respectively. Potential publication bias was evaluated by Egger's test. Sensitivity analysis was also performed to evaluate the stability and reliability in results. Results: Decreased susceptibility of LC was found in all genetic models contrast in Bsm1 gene of VDR (a vs. A: OR = 0.62, 95 % CI = 0.44-0.87; aa vs. AA: OR = 0.76, 95 % CI = 0.60-0.96; Aa vs. AA: OR = 0.59, 95 % CI = 0.39-0.88; aa vs. AA+Aa: OR = 0.80, 95 % CI = 0.64-0.99; Aa+aa vs. AA: OR = 0.57, 95 % CI = 0.37-0.86). The similar results were also found in partial genetic models of Taq1 (a vs. A: OR = 0.88, 95 % CI = 0.79-0.98; aa vs. AA+Aa: OR = 0.84, 95 % CI = 0.73-0.98) and Cdx-2 (Aa vs. AA: OR = 0.80, 95 % CI = 0.66-0.98; Aa+aa vs. AA: OR = 0.79, 95 % CI = 0.65-0.96). Likewise, significant correlation between Bsm1, Taq1 polymorphism and LC risk was detected among Asians. Cdx-2 polymorphism was considered as a protective factor in Caucasians, whereas no association of Apal polymorphism with LC risk was observed in Asians and Caucasians for all genetic models. Conclusion: The results of this meta-analysis suggested that Bsm1, Taq1 and Cdx-2 polymorphism may contribute to lung cancer susceptibility, more studies need be conducted to confirm in the future.

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“…The results indicated that polymorphisms in the VDR gene are associated with a greater risk of lung cancer compared to those without such variations. Moreover, the researchers found that the risk of lung cancer increased with the number of VDR gene variations present in an individual [ 78 ]. This provides evidence that VDR gene variations may be an important factor in lung cancer risk.…”

Section: Vitamin D Receptor Gene Variation and Lung Cancer Riskmentioning

confidence: 99%

Exploring the Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor Gene Variation in Lung Cancer Risk

Ciocarlie,

Motofelea,

Motofelea

et al. 2024

IJMS

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Lung cancer has an unfavorable prognosis with a rate of low overall survival, caused by the difficulty of diagnosis in the early stages and resistance to therapy. In recent years, there have been new therapies that use specific molecular targets and are effective in increasing the survival chances of advanced cancer. Therefore, it is necessary to find more specific biomarkers that can identify early changes in carcinogenesis and allow the earliest possible treatment. Vitamin D (VD) plays an important role in immunity and carcinogenesis. Furthermore, the vitamin D receptor (VDR) regulates the expression of various genes involved in the physiological functions of the human organism. The genes encoding the VDR are extremely polymorphic and vary greatly between human populations. To date, there are significant associations between VDR polymorphism and several types of cancer, but the data on the involvement of VDR polymorphism in lung cancer are still conflicting. Therefore, in this review, our aim was to investigate the relationship between VDR single-nucleotide polymorphisms in humans and the degree of risk for developing lung cancer. The studies showcased different gene polymorphisms to be associated with an increased risk of lung cancer: TaqI, ApaI, BsmI, FokI, and Cdx2. In addition, there is a strong positive correlation between VD deficiency and lung cancer development. Still, due to a lack of awareness, the assessment of VD status and VDR polymorphism is rarely considered for the prediction of lung cancer evolution and their clinical applicability, despite the fact that studies have shown the highest risk for lung cancer given by TaqI gene polymorphisms and that VDR polymorphisms are associated with more aggressive cancer evolution.

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The Association of Vitamin D Receptor Gene Polymorphism with Lung Cancer Risk: An Update Meta-analysis

Cited by 9 publications

References 11 publications

The Association BetweenVDRandGCPolymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis

The Association BetweenVDRandGCPolymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis

Exploring the Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor Gene Variation in Lung Cancer Risk

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