The Association of Vitamin D Deficiency and Insufficiency with Diabetic Nephropathy: Implications for Health Disparities

Díaz, Vanessa A.; Mainous, Arch G.; Carek, Peter J.; Wessell, Andrea M.; Everett, Charles J.

doi:10.3122/jabfm.2009.05.080231

Cited by 78 publications

(60 citation statements)

References 23 publications

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“…Recent studies reported that exaggerated urinary loss of VDBP in DN could contribute mechanistically to vitamin D deficiency which is highly prevalent in diabetes mellitus [14,33]. Moreover, other studies suggested that vitamin D deficiency may have an important role in the progressive loss of renal function and is independently associated with the development of DN [34]. Therefore, in diabetes patients with hypovitaminosis D, vitamin D deficiency which results from urinary wasting of VDBP may lead to further impairment of renal function and accentuation of DN.…”

Section: Discussionmentioning

confidence: 97%

Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus

2015

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Diabetic nephropathy is a serious complication of both type 1 and type 2 diabetes and, unless arrested, leads to end-stage renal disease. Therefore, early prediction and detection of DN would greatly benefit the disease management and delay its progression. The aim of this study is to evaluate the levels of urinary monocyte chemoattractant protein-1 (uMCP-1) and urinary vitamin D-binding protein (uVDBP) in type 2 diabetic patients with different degrees of diabetic nephropathy (DN) and to assess the value of uMCP-1 and uVDBP in the early detection of DN. Seventy-five type 2 diabetic patients with normoalbuminuria (n = 25), microalbuminuria (n = 25), macroalbuminuria (n = 25), and 25 healthy controls were included in this study. Urinary MCP-1 and VDBP levels were evaluated by enzyme-linked immunosorbent assay. A significant elevation in the uMCP-1 and uVDBP levels was found in macroalbuminuric (p < 0.001) and microalbuminuric (p < 0.01) diabetic patients compared to that in normoalbuminuric diabetic patients and control subjects (p < 0.001). Correlation study revealed that both uMCP-1 and uVDBP were significantly positively correlated to urinary albumin/creatinine ratio (r = 0.968, p < 0.001 and r = 0.973, p < 0.001, respectively), serum urea (r = 0.461, p = 0.001 and r = 0.456, p = 0.002, respectively), and serum creatinine (r = 0.475, p = 0.001 and r = 0.448, p = 0.004, respectively) and significantly inversely correlated to glomerular filtration rate (r = -0.983, p < 0.001 and r = -0.988, p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis of uMCP-1 and uVDBP levels for early diagnosis and detection of DN revealed that the cut-off value of uMCP-1 was 110 pg/mg with 92% sensitivity and 100% specificity; whereas, the cut-off value of uVDBP was 550 ng/mg with 96% sensitivity and 84% specificity. The findings of the present study suggest that uMCP-1 and uVDBP may be considered as novel potential diagnostic biomarkers for the early detection of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 97%

Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus

2015

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“…Studies by Tahrani, Bucan and Svoren similarly showed deficiency in vitamin D in patients with diabetes (27)(28)(29). Vitamin D deficiency mechanism in children is different (30) and in patients with diabetes type 1 it includes genetic susceptibility factors, accompanying albuminuria or renal excretion of vitamin D and/or its metabolites (28,31).…”

Section: Discussionmentioning

confidence: 99%

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

et al. 2017

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Background: Type 1 Diabetes mellitus (DM) causes changes in bone mineral density (BMD). Objectives: The aim of this study was to evaluate BMD in children with type 1 DM and predictive factors of BMD loss in these patients. Methods: This cross-sectional study was conducted on 112 children with type 1 DM referrtd to children's medical center in Tehran, Iran during 2015 and 2016. Serum levels of hemoglobin A1c (HbA1c), Insulin-like growth factor 1 (IGF-1), 25-hydroxy vitamin D (25(OH) D), calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphates (ALP), Fasting blood sugar (FBS) was recorded. Lumbar

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“…Our findings add to the growing body of evidence that low levels of vitamin D among Blacks contribute to cardiovascular disparities. Suboptimal vitamin D has been linked to conditions more prevalent among Blacks including diabetic nephropathy, 48 peripheral vascular disease, 49 kidney disease progressing to renal failure, 50 and cardiovascular mortality. 51 Blacks also have higher rates of endothelial dysfunction and small vessel disease than whites.…”

Section: Discussionmentioning

confidence: 99%

Racial Disparity in Blood Pressure: is Vitamin D a Factor?

et al. 2011

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The Association of Vitamin D Deficiency and Insufficiency with Diabetic Nephropathy: Implications for Health Disparities

Cited by 78 publications

References 23 publications

Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus

Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

Racial Disparity in Blood Pressure: is Vitamin D a Factor?

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