The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

Abstract

Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.

Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population

“…Regarding the relationship between 25(OH)D and lipid profile, we found an inverse association between 25(OH)D levels and LDL cholesterol, non-HDL cholesterol, and a direct association between 25(OH)D and HDL [51][52][53][54], confirming previous studies. Various mechanisms have been suggested to explain the relation between 25(OH)D and lipid metabolism: (i) vitamin D and its metabolites play a role in cholesterol synthesis inhibiting 3-hydroxy-3methyl-glutaryl-CoA-reductase and lanosterol 14a-demethylase enzyme activity in cultured cells [55]; (ii) lower LDL-C concentrations have been observed in people with higher sunlight exposure, although it is not known whether the exposure to sunlight affects cholesterol metabolism indirectly, by improving the status of vitamin D, or directly; (iii) vitamin D is essential to maintain the necessary levels of apolipoprotein A-1, the main component of HDL [56].…”

The role of vitamin D in subjective tinnitus—A case-control study

“…Indeed, there is evidence that vitamin D may have beneficial effects on serum lipid profiles, and its supplementation may diminish serum total cholesterol, LDL cholesterol, and triglyceride levels [ 71 ]. Some studies suggest that serum 25(OH)D is inversely correlated with levels of LDL cholesterol and triglycerides, and positively correlated with the level of HDL cholesterol [ 72 , 73 ]. On the other hand, dyslipidemia is frequent in tinnitus patients, and tinnitus can be successfully dealt with by treating hyperlipidemia with lipid lowering agent atorvastatin [ 74 , 75 ].…”

Vitamin D Deficiency as a Predictor of a High Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates With Type 1 Diabetes

“…revealed that the HDL level was lower in the group with 25(OH)D levels <25 ng/ml compared to the group with 25(OH)D levels ≥25 ng/ml. A significant positive association was found between serum levels of vitamin D and HDL ( 45 ). The mentioned authors found a significant negative association between vitamin D level and both serum tumor necrosis factor receptor-2 (TNFR-2) and high-sensitive C-reactive protein (hsCRP) in that study.…”