The association of white lesions with oral squamous cell carcinoma. A retrospective study of 212 patients

Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population

“…In this review, we analysed the data on malignant transformation of OL and presented the hospital‐based epidemiological as well as clinical characteristics of these Chinese patients. The analysis in this review showed that women tended to have a higher MTR in China. This finding is similar to that reported in other published studies outside China.…”

Progress in determining the malignant potential of oral lesions

“…However, leukoplakias are far more common (13–15) and may also have potential for transformation into OSCC (16, 17). However, only a minority of potentially malignant lesions progress to OSCC (11), the overall incidence of cancer development ranging from 4.4 to 31.4% (7, 18, 19) or to as high as 36% when moderate or severe dysplasia is present (20). A follow‐up study of a hospital‐based population of 166 patients with oral leukoplakia revealed a 2.9% annual malignant transformation rate (21).…”

“…Most cancers of the oral cavity are squamous cell carcinomas (OSCC), and many are preceded by clinically evident potentially malignant oral mucosal lesions, particularly erythroplakia and some leukoplakias (5, 6). In one series of 212 Dutch patients with a histologically proven OSCC, there were coexistent white lesions in 48% of the patients (7). In societies where the incidence of oral cancer is high, clinically recognisable pre‐malignant lesions are particularly common (8).…”

The prevalence of oral leukoplakia in 138 patients with oral squamous cell carcinoma

“…The fact that some oral leukoplakias (OLs) undergo malignant transformation during their clinical evolution (Pindborg et al , 1968; Silverman et al , 1984; Schepman et al , 1998) and that white lesions are found on the borders of some oral squamous cell carcinomas (OSCC) (Hogewind et al , 1989; Schepman et al , 1999), lends support to the concept that OL is a potentially malignant lesion.…”