The associations between hematological parameters and the incidence of prehypertension and hypertension in children and adolescents: a prospective cohort study

Huang, Lan; Chen, Song; Q, Liu; Liang, Xiaoyue; Ren, Yanling; Huang, Daochao; Guan, Xianmin; An, Xizhou; Liang, Xiaohua

doi:10.1038/s41440-023-01304-z

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…Males in the fourth vs. the first quartile of platelet counts displayed 5-fold higher and females had 4-fold higher odds for MetS [28]. A longitudinal study involving initially healthy Chinese children aged 6 to 8 years revealed that at a follow-up conducted 5 years later, the incidence of prehypertension and hypertension was 3.3-fold higher in those with erythrocyte counts within the fourth quartile vs. the first quartile at baseline [21]. Longitudinal studies in adults document that a rise in leukocyte, erythrocyte, or platelet counts within their normal range is associated with an increased incidence of type 2 diabetes, cardiovascular diseases, and mortality later (reviewed in [16]).…”

Section: Discussionmentioning

confidence: 99%

“…Simultaneous evaluation of erythrocyte and leukocyte counts in adolescents using Bayesian modeling indicated their correlation with waist-to-height ratio (WHtR), BP, FPG, and TAG levels, while only erythrocyte counts correlated significantly with HDL-C levels [20]. Erythrocyte counts are higher in children with prehypertension and hypertension than in their normotensive peers [21]. Erythropoiesis is a constant source of endogenous uric acid [22].…”

Section: Introductionmentioning

confidence: 99%

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Association of Leukocyte, Erythrocyte, and Platelet Counts with Metabolic Syndrome and Its Components in Young Individuals without Overt Signs of Inflammation: A Cross-Sectional Study

Šebeková,

Gurecká,

Podracká

2024

Children

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The presence of metabolic syndrome (MetS) increases the risk of developing type 2 diabetes, cardiovascular diseases, and mortality. MetS is associated with increased leukocyte or erythrocyte counts. In 16- to 20-year-old males (n = 1188) and females (n = 1231) without signs of overt inflammation, we studied whether the presence of MetS and its components results in elevated blood cell counts. The leukocyte, erythrocyte, and thrombocyte counts significantly but weakly correlated with the continuous MetS score, MetS components, uric acid, and C-reactive protein levels both in males (r = −0.09 to 0.2; p < 0.01) and females (r = −0.08 to 0.2; p < 0.05). Subjects with MetS had higher leukocyte (males: 6.2 ± 1.3 vs. 6.9 ± 1.2 × 109/L; females 6.6 ± 1.5 vs. 7.5 ± 1.6 × 109/L; p < 0.001), erythrocyte (males: 5.1 ± 0.3 vs. 5.3 ± 0.3 × 1012/L; females: 4.5 ± 0.3 vs. 4.8 ± 0.3 × 1012/L; p < 0.001), and platelet counts (males: 245 ± 48 vs. 261 ± 47 × 109/L; females: 274 ± 56 vs. 288 ± 74 × 109/L; p < 0.05) than those without MetS. With the exception of platelet counts in females, the blood counts increased with the number of manifested MetS components. Phenotypes with the highest average leukocyte, erythrocyte, or platelet counts differed between sexes, and their prevalence was low (males: 0.3% to 3.9%; females: 1.2% to 2.7%). Whether functional changes in blood elements accompany MetS and whether the increase in blood counts within the reference ranges represents a risk for future manifestation of cardiometabolic diseases remain unanswered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Leukocyte, Erythrocyte, and Platelet Counts with Metabolic Syndrome and Its Components in Young Individuals without Overt Signs of Inflammation: A Cross-Sectional Study

Šebeková,

Gurecká,

Podracká

2024

Children

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Hypertension in children and adolescents: perspectives in Japan

Fujiwara,

Kaneko,

Hayashi

et al. 2024

Hypertens Res

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Dimethyl Fumarate Prevents the Development of Chronic Social Stress-Induced Hypertension in Borderline Hypertensive Rats

Kluknavsky,

Balis,

Liskova

et al. 2024

Antioxidants

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This study investigated the effects of chronic crowding-induced social stress and dimethyl fumarate (DMF) on borderline hypertensive rats, focusing on the transcription nuclear factor (erythroid-derived 2)-like 2 (NRF2) gene Nfe2l2, on the expression of selected NFR2-mediated gene expressions in the heart, and on vascular function. Rats were exposed to chronic crowding, DMF treatment (30 mg/kg/day, p.o.), or a combination of both for six weeks. Blood pressure (BP) was measured non-invasively, gene expressions were analysed using RT-qPCR, and vascular function was assessed by measuring noradrenaline (NA)-induced vasoconstriction and endothelium-dependent and -independent relaxations in the femoral arteries using a wire myograph. Chronic stress increased BP, Nfe2l2 expression, and NA-induced vasoconstriction, though it did not affect relaxation responses nor the left heart ventricle-to-body weight (LHV/BW) ratio. DMF elevated Nfe2l2 expression (as the main effect) in the heart but did not alter BP and vascular functions vs. control when administered alone. Interestingly, DMF increased the LHV/BW ratio, supposedly due to reductive stress induced by continuous NRF2 activation. When combined with stress, DMF treatment prevented stress-induced hypertension and mitigated NA-induced vasoconstriction without altering relaxation functions. In addition, the combination of stress and DMF increased Tnf and Nos2 expression and the expressions of several genes involved in iron metabolism. In conclusion, these findings suggest that DMF can prevent chronic stress-induced hypertension by reducing vascular contractility. Moreover, DMF itself may produce reductive stress in the heart and induce inflammation when combined with stress. This indicates a need for the careful consideration of long-term DMF treatment considering its impact on the heart.

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The associations between hematological parameters and the incidence of prehypertension and hypertension in children and adolescents: a prospective cohort study

Cited by 3 publications

References 39 publications

Association of Leukocyte, Erythrocyte, and Platelet Counts with Metabolic Syndrome and Its Components in Young Individuals without Overt Signs of Inflammation: A Cross-Sectional Study

Association of Leukocyte, Erythrocyte, and Platelet Counts with Metabolic Syndrome and Its Components in Young Individuals without Overt Signs of Inflammation: A Cross-Sectional Study

Hypertension in children and adolescents: perspectives in Japan

Dimethyl Fumarate Prevents the Development of Chronic Social Stress-Induced Hypertension in Borderline Hypertensive Rats

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