The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

El-Saed, Aiman; Okamura, Tomonori; Evans, Rhobert W.; Nakamura, Yasuyuki; Willcox, Bradley J.; Lee, S.; Maegawa, Hiroshi; Seto, Todd B.; Choo, Jina; Fujiyoshi, Akira; Miura, Katsuyuki; Kuller, Lewis H.; Ueshima, H.

doi:10.1007/s12603-016-0670-9

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…In addition, inclusion criteria differed between the two cohorts, allowing for the inclusion of some individuals with a history of DOI: 10.4236/fns.2018.96054 707 Food and Nutrition Sciences cardiometabolic diseases in the US cohort but not the Japanese. Since the differences we observed have been reported in larger cohorts [27], our findings were unlikely to have been affected by these limitations.…”

Section: Discussionmentioning

confidence: 53%

Plasma Fatty Acid Composition in Men over 50 in the USA and Japan

Takada¹,

Shimizu²,

Ishii³

et al. 2018

FNS

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Background: Coronary heart disease (CHD) rates differ markedly between the US and Japan. Fatty acid profiles have been linked to risk for CHD. Few studies have compared the plasma fatty acid composition, including trans fatty acids, in Japanese and US subjects. Methods: Fasting blood samples were taken from healthy older (>age 50) American (n = 76) and Japanese (n = 44) men, and plasma levels of 23 fatty acids were analyzed by gas chromatography and expressed as a percent of total fatty acids. Results: As expected, plasma levels of long-chain ω3 fatty acids (docosahexaenoic and eicosapentaenoic acids, DHA and EPA) were higher in Japanese men and ω6 fatty acids (e.g., arachidonic acid, AA) were lower compared with American men. Plasma levels of the major industrially-produced trans fatty acids (IP-TFAs; elaidic and linoelaidic acids) were far higher in American men, and levels of the potentially cardioprotective, primarily ruminant-derived trans fatty acid palmitoelaidic acid (POA) were higher in Japanese. Plasma levels of saturated or monounsaturated fatty acids were also higher in the American men. Conclusion: There are multiple differences in plasma fatty acid profiles between American and Japanese older men. The higher levels of DHA and EPA, along with the lower levels of the IP-TFAs, are consistent with the markedly lower risk for coronary heart disease in Japan vs. the US.

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Section: Discussionmentioning

confidence: 53%

Plasma Fatty Acid Composition in Men over 50 in the USA and Japan

Takada¹,

Shimizu²,

Ishii³

et al. 2018

FNS

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“…Our findings of the inverse associations of the serum total n-6 PUFA or LA with CRP are supported by several previous epidemiological observations, 11,[13][14][15][16][17][18][19][20] although some epidemiological studies have not found associations 8,9,21 or inverse associations have been found only in the subgroup analyses. 10,22 There is also evidence from randomized trials that even very large changes in LA intake do not substantially affect circulating AA concentrations 30 and do not increase inflammation markers. 7 Similarly, AA supplementation has not had an impact on inflammation markers, 31,32 not even with several fold higher doses (1.5 g/d) compared to typical dietary intakes.…”

Section: Discussionmentioning

confidence: 99%

“…Although several epidemiological studies have evaluated the associations of the n-6 PUFAs with inflammation markers, the findings have been heterogeneous. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Use of circulating PUFAs would remove the bias associated with dietary assessment methods and would also make it possible to investigate the associations of the mainly endogenously produced n-6 PUFAs, gamma-linolenic acid (GLA) and dihomo-gamma-linolenic acid (DGLA). However, only few studies have investigated the associations of GLA or DGLA with inflammation, again with heterogeneous results.…”

Section: Introductionmentioning

confidence: 99%

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

et al. 2017

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“…Excessive TFA intake is also assumed to induce abnormal glucose metabolism 11,23,24 and elevated inflammatory biomarkers. 25,26 But while mean HbA1c increased in patients with higher elaidic acid, no significant difference was noted in elaidic acid quartiles. In addition, serum hs-CRP was not associated with elaidic acid level.…”

Section: Discussionmentioning

confidence: 91%

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

Oshita

Toh

Shinohara

et al. 2019

Circ J

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Background: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Methods and Results: A total of 112 patients (age, 21-66 years) who underwent percutaneous coronary intervention were followed up for up to 2 years. Serum elaidic acid was measured using gas chromatography/mass spectrometry as a marker of TFA intake and divided into quartiles. The primary endpoint was ischemia-driven target lesion revascularization (TLR). The hazard ratio (HR) for TLR increased significantly with higher serum elaidic acid (P<0.01). The significant positive trend remained unchanged after adjusting for conventional lipid profile and bare-metal stent usage. In contrast, although triglycerides and low-density lipoprotein cholesterol were positively correlated with elaidic acid, they were not associated with TLR. On multivariable Cox proportional hazard analysis, elevated elaidic acid was independently associated with TLR risk after adjusting for conventional coronary risks (HR,

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The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

Abstract: With the exception of consistent inverse association of CRP with total n-6 FAs, there are considerable variations across the three populations in the associations of CRP with different FAs.

Cited by 6 publications

References 33 publications

Plasma Fatty Acid Composition in Men over 50 in the USA and Japan

Plasma Fatty Acid Composition in Men over 50 in the USA and Japan

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

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