The associations of HLA-A, -B, DRB1 alleles and haplotypes in Turkish lymphoma patients

Uçar, Fahri; Sönmez, Mehmet; Ermantaş, Nilay; Özbaş, Hasan Mücahit; Cansız, Abide; Balcı, Mustafa; Yılmazz, Mustafa

doi:10.1016/j.gene.2016.04.017

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Wang et al [ 20 ] also found that B*46:01 and DQB1*06:02 may be protective and susceptible genes for MDS, respectively, consistent with the results of this study. Uçar et al [ 23 ] discovered higher frequencies of HLA-A*29 (OR: 5.65; Pc = 0.001), B*07 (OR: 3.00; Pc = 0.003), and DRB1*11 (OR: 1.80; Pc = 0.002) alleles in patients with Hodgkin’s lymphoma compared with controls. Significantly increased allele frequencies of HLA-DQA1*01:03 and HLA-DQB1*06:01 have also been reported in lymphoma [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

Li,

et al. 2024

PLoS ONE

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Several genes involved in the pathogenesis have been identified, with the human leukocyte antigen (HLA) system playing an essential role. However, the relationship between HLA and a cluster of hematological diseases has received little attention in China. Blood samples (n = 123913) from 43568 patients and 80345 individuals without known pathology were genotyped for HLA class I and II using sequencing-based typing. We discovered that HLA-A*11:01, B*40:01, C*01:02, DQB1*03:01, and DRB1*09:01 were prevalent in China. Furthermore, three high-frequency alleles (DQB1*03:01, DQB1*06:02, and DRB1*15:01) were found to be hazardous in malignant hematologic diseases when compared to controls. In addition, for benign hematologic disorders, 7 high-frequency risk alleles (A*01:01, B*46:01, C*01:02, DQB1*03:03, DQB1*05:02, DRB1*09:01, and DRB1*14:54) and 8 high-frequency susceptible genotypes (A*11:01-A*11:01, B*46:01-B*58:01, B*46:01-B*46:01, C*01:02-C*03:04, DQB1*03:01-DQB1*05:02, DQB1*03:03-DQB1*06:01, DRB1*09:01-DRB1*15:01, and DRB1*14:54-DRB1*15:01) were observed. To summarize, our findings indicate the association between HLA alleles/genotypes and a variety of hematological disorders, which is critical for disease surveillance.

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Section: Discussionmentioning

confidence: 99%

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

Li,

et al. 2024

PLoS ONE

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“…The existence of the HLA-DR15 allele suggested MDS susceptibility, which is consistent with our findings. Uçar et al(Uçar et al . 2016) discovered higher frequencies of HLA-A*29 (OR: 5.65; Pc = 0.001), B*07 (OR: 3.00; Pc = 0.003), and DRB1*11 (OR: 1.80; Pc = 0.002) alleles in patients with Hodgkin’s lymphoma compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…Uçar et al(Uçar et al 2016) discovered higher frequencies of HLA-A*29 (OR: 5.65; Pc = 0.001), B*07 (OR: 3.00; Pc = 0.003), and DRB1*11 (OR: 1.80; Pc = 0.002) alleles in patients with Hodgkin's lymphoma compared with controls. Significantly increased allele frequencies of HLA-DQA1*01:03 and HLA-DQB1*06:01 have also been reported in lymphoma…”

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confidence: 91%

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

Zheng¹,

Li²,

Li³

et al. 2023

Preprint

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Background: Serveral genes involved in the pathogenesis have been identified and a crucial role is known to be played by the human leukocyte antigen (HLA) system. However, the relationship between HLA and a cluster of hematological diseases has been rarely reported in China.Methods: Blood samples (n=123,913) from 43,568 patients and 80,345 individuals without known pathology were genotyped using sequence-based typing (SBT) for HLA class I and II.Results: The HLA-A*11:01, B*40:01, C*01:02, DQB1*03:01, and DRB1*09:01 were common in China. Additionally, compared to controls, in malignant hematologic diseases, 3 high-frequency alleles (DQB1*03:01, DQB1*06:02, and DRB1*15:01) were risky. And we observed 7 high-frequency risk alleles (A*01:01, B*46:01, C*01:02, DQB1*03:03, DQB1*05:02, DRB1*09:01, and DRB1*14:54) and 8 high-frequency susceptible genotypes (A*11:01-A*11:01, B*46:01-B*58:01, B*46:01-B*46:01, C*01:02-C*03:04, DQB1*03:01-DQB1*05:02, DQB1*03:03-DQB1*06:01, DRB1*09:01-DRB1*15:01, and DRB1*14:54-DRB1*15:01) for benign hematologic diseases. Conclusion: Our results support the association between HLA alleles/genotypes and multiple hematological disorders, which is essential in disease surveillance.

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“…Common environmental triggers, altered immune system, genetic factors and long-term use of immunosuppressants may be responsible for development of malignancy in BD (10)(11)(12)(13). In addition to the role in BD pathogenesis, the HLA-B51 polymorphism has also been reported to be related with lymphoma, cervical carcinoma, papillary thyroid carcinoma (14)(15)(16). In BD long-term ongoing inflammation may cause comorbidities and mortality but whether it provokes malignancy development is yet to be clarified (4).…”

Section: Introductionmentioning

confidence: 99%

The relationship between malignancy and Behçet's disease features

Doğan

Armağan

Gök

et al. 2022

Journal of Health Sciences and Medicine

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Introduction: Behçet's disease (BD) is an autoimmune, multisystemic vasculitis characterized by chronic inflammation. Autoimmune responses in BD could drive chronic inflammation which is a risk for malignant transformation. Some genetic, environmental, clinical features and immunosuppressive treatments in BD may increase the risk of malignancy. Common genetic factors and similar environmental factors play a role in the pathogenesis of some autoimmune diseases and malignancies. We hypothesized that the frequency of comorbidity and clinical features of BD may differ in BD patients with a family history of malignancy. So, we aimed to compare the demographic and clinical characteristics features of the BD patients with and without a family history of malignancy. Material and Method:The BD patients who admitted the rheumatology outpatient clinic consecutively were included in the study. The demographic and clinical characteristics, comorbidities including malignancy in BD patients and malignancies in their family were questioned. The acute phase reactant elevation of at least two follow-ups was accepted as chronic inflammation.Results: A total of 98 patients (57% male) were included. Mean age was 43.5±12.3 years. The frequency of comorbidity was 60% and malignant/premalignant lesions were seen in 5% of the patients. All lesions were solid organ related and all of them were in women. History of BD and malignancy in patients' families was found 28% and 38%, respectively. The patients with and without malignancy in their family were compared. Female gender and the frequency of erythema nodosum were higher in the patients with malignancy in their family. The other demographic and clinical characteristics, chronic persistent inflammation and medical treatments were statistically. not different Conclusion: Frequency of malignancy in BD patients' family was evaluated and to the best of our knowledge, there was no literature data on this subject interestingly. The family history of malignancy in BD patients could be associated with clinical characteristics. Further prospective studies were needed to show the clinical effect of malignancy history in families.

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The associations of HLA-A, -B, DRB1 alleles and haplotypes in Turkish lymphoma patients

Cited by 6 publications

References 28 publications

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

Investigation of HLA susceptibility alleles and genotypes with hematological disease among Chinese Han population

The relationship between malignancy and Behçet's disease features

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