The Associations of<i>IL-6, IFN-γ, TNF-α, IL-10,</i>and<i>TGF-β1</i>Functional Variants with Acute Myeloid Leukemia in Turkish Patients

Nursal, Ayşe Feyda; Pehlıvan, Mustafa; Şahin, Handan Haydaroğlu; Pehlıvan, Sacide

doi:10.1089/gtmb.2016.0036

Cited by 19 publications

(20 citation statements)

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“…Pehlivan et al found no significant differences between Turkish patients with Philadelphia positive CML and their controls . Contrary to our observations, no difference was observed in a Turkish population for the TGF‐β1 rs1800470 variant genotype …”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, we observed no differences regarding the frequency of IL‐6 rs1800795 genotypes or alleles among AML patients and controls, our data being similar to the results reported by Nursal et al In contrast, the presence of the rs1800795 variant genotype could be associated with CML susceptibility in Turkish patients …”

Section: Discussionsupporting

confidence: 90%

“…In the present study, no relationship was found between IL‐10 rs1800872 and rs1800896 and AML predisposition. These findings are in line with certain studies reported previously ; however, they are also in contradiction with several others …”

Section: Discussionsupporting

confidence: 85%

“…Moreover, a recent study reported that the presence of the IL‐10 rs1800872 variant allele was associated with a slightly increased risk of AML (adjusted OR = 1.30 95% CI: 1.01‐1.72) . Nursal et al showed that variants of the IL‐10 (rs1800896 and rs1800872) gene may have a significant association with AML etiopathogenesis …”

Section: Discussionmentioning

confidence: 99%

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Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia

et al. 2019

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Background Cytokines were correlated with survival and disease progression in acute myeloid leukemia (AML). We aimed to evaluate the multivariate effect of TNF‐α rs361525, rs1800750, rs1800629, IL‐10 rs1800896, rs1800872, IL‐6 rs1800795, TGF‐β1 rs1800470, IFN‐γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML. Methods All SNPs were genotyped in 226 adult AML cases and 406 healthy individuals. AML patients were investigated for FLT3 (ITD, D835), DNMT3A (R882), and NPM1 type A mutations. Results Univariate analysis revealed that age above 65 years had a negative influence on survival (P < .001). The presence of the rs1800750 variant genotype (P = .005) or FLT3‐ITD mutation (P = .009) in a cytogenetic high‐risk group (P = .003) negatively influenced OS. A negative association was observed between Eastern Cooperative Oncologic Group Scale status > 2, lactate dehydrogenase (LDH) level, platelet (PLT) count <40 000 cells/mm3, and OS. Multivariate Cox regression analysis showed that the presence of the rs1800750 variant genotype was a risk factor for death (P = .007), and that blast percentage, LDH level (≥600 IU/L), and cytogenetic high‐risk were independent significant predictors for death in AML (P = .04, corrected HR = 1.20; P = .022, corrected HR = 1.24; P = .021, corrected HR = 1.34, respectively). Conclusions Age above 65 years, PLT count, TNF‐α rs1800750 variant genotype, blast percentage, LDH level, and cytogenetic high‐risk may be used as independent risk factors to assess AML mortality.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia

et al. 2019

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“…In this study, the IL-10 gene SNPs -1082, -819, -592 and their genotypic combinations in 100 SP patients and 100 volunteer-healthy controls in the Turkish population were Wide variation has been also recorded in the frequencies of IL-10 gene's promoter SNPs among distinct populations. Despite the fact that the global prevalence notified of the allele frequencies of -1082, -819, and -592 SNPs in IL-10 gene in control groups vary, and they are same to last studies in Turkish society [13,21,22].…”

Section: Discussionmentioning

confidence: 83%

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Özdaş¹

2018

Hittite J. Sci. Eng.

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Sinonasal polyposis (SP) is a cronic inflammation of the sinonasal mucosa. Chronic sinusitis, odor loss headache and nasal obstruction are among the clinical symptoms of SP with low life quality among the patients. Sinonasal polyposis is often accompanied by allergic rhinitis, allergy, aspirin susceptibility and asthma [1]. SP has been implicated in many immunological pathways and is a localized manifestation of systemic disorders [2,3]. SP cases frequently accompanied by T helper (Th) type 1-, Th2-, or Th17-biased inflammatory processes regulated by increased expression levels of a number of cytokines with pro-and anti-inflammatory activities [4]. However, the underlying etiology of SP is multifactorial. Also the pathogenesis of SP is still unexplained.Interleukin (IL)-10 is a crucial Th2 group anti-inf-

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Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia

Wu,

Li,

Meng

et al. 2023

Cancer Medicine

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BackgroundChemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML.MethodsWe detected nine single nucleotide polymorphisms (SNPs) in immune checkpoint‐related genes, including PD1, LAG3, TIM3, and TIGIT in 285 AML inpatients and 324 healthy controls. SNP genotyping was performed on the MassARRAY platform. Furthermore, we analyzed the relationship between the susceptibility and prognosis of AML and the selected SNPs.ResultsOur results showed that rs2227982 and rs10204525 in PD1 were significantly associated with susceptibility to AML after false discovery rate correction. PD1 rs10204525 also showed a significant correlation with the response to chemotherapy and risk stratification of AML. Importantly, the AA genotype of PD1 (rs2227982) under the recessive model showed a negative impact on AML prognosis independently.ConclusionsOur results indicate that PD1 SNPs are important for susceptibility and prognosis in AML, which may provide a new therapeutic target for AML patients.

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The Associations ofIL-6, IFN-γ, TNF-α, IL-10,andTGF-β1Functional Variants with Acute Myeloid Leukemia in Turkish Patients

Cited by 19 publications

References 55 publications

Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia

Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia

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