The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

Ermakov, Simon; Azarbal, Farnaz; Stefanick, Marcia L.; LaMonte, Michael J.; Li, Wenjun; Tharp, Katie M.; Martin, Lisa W.; Nassir, Rami; Salmoirago‐Blotcher, Elena; Chen, Albert; Manson, JoAnn E.; Assimes, Themistocles L.; Hlatky, Mark A.; Larson, Joseph C.; Pérez, Marco

doi:10.1136/heartjnl-2015-308927

Cited by 37 publications

(30 citation statements)

References 30 publications

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“…Moreover, the renin–angiotensin system is activated in patients with low body weight, leading to advanced atrial fibrosis . Finally, adipokines such as leptin, adiponectin, and resistin, which are correlated with BMI, have been reported to be involved in the development of AF . As shown by Haynes et al, low body weight is associated with abnormal circulating adipokine levels, which may contribute to eating disorders and poor nutritional status .…”

Section: Discussionmentioning

confidence: 99%

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta‐Analysis and Systematic Review

Zhu

Wan²,

Liu

et al. 2016

JAHA

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Section: Discussionmentioning

confidence: 99%

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta‐Analysis and Systematic Review

Zhu

Wan²,

Liu

et al. 2016

JAHA

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“…In contrast to our study, Ermakov at al. revealed that in a group of postmenopausal women (50-79 years-old), during over 11 years of observation, serum resistin levels were independently associated with new AF onset [13]. The authors concluded that resistin may be considered as a biomarker that partially mediates the relationship between obesity and AF.…”

Section: Baseline Adipokine Levels and Future Atrial Fibrillation Devmentioning

confidence: 97%

Are adipokines associated with atrial fibrillation in type 2 diabetes?

Peller

Kapłon‐Cieślicka

Rosiak

et al. 2020

Endokrynologia Polska

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Introduction:The potential effect of adipokines on the development of AF is yet to be established. The aim of this study was to investigate the association of baseline serum adipokines with 1) the presence of AF at baseline and 2) future risk of AF development. Material and methods:The current study is a sub-analysis of the prospective, randomised AVOCADO (Aspirin Vs./Or Clopidogrel in Aspirin-resistant Diabetics inflammation Outcomes) trial. The AVOCADO study included patients with type 2 DM burdened with at least two additional cardiovascular risk factors and receiving acetylsalicylic acid. In patients included in the current analysis adipokines and inflammatory biomarker levels were measured. Information on the subsequent AF diagnosis was collected after a median of 5.4 years of follow-up. Results: A total of 273 patients with type 2 DM (median age 68 years; 52% male) were included in the initial analysis comparing patients with and without AF at baseline. Patients with diagnosed AF (12%) had higher levels of serum resistin [8.5 (5.8-10.5) vs. 6.9 (5.6-8.7) ng/mL; p = 0.034], adiponectin [6.9 (5.6-8.7) vs. 2.7 (1.8-4.2) ng/mL; p = 0.032], and N-terminal pro-B-type natriuretic peptide (336 [148-473] vs. 108 ; p < 0.001) than non-AF patients. There were no significant differences in serum leptin, IL-6, and TNF-a concentrations between the two groups. From subjects without known AF at study entry, 19% developed AF at follow-up. In logistic regression analysis, baseline adipokine levels did not predict AF development. Conclusion: In type 2 DM, patients with AF have higher resistin and adiponectin concentrations than patients with no AF. None of the studied adipokines proved a predictor of future AF development. (Endokrynol Pol 2020; 71 (1): 34-41)

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“…Over a follow-up of 11.1 years, 18% of 4937 women developed AF 5. In multivariable analysis, adiponectin and leptin were not found to predict incident AF in their cohort.…”

mentioning

confidence: 92%

Obesity and atrial fibrillation: can adipokines help to solve this puzzle: Table 1

Güngör

2016

Heart

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The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

Abstract: In women, elevated levels of serum resistin are significantly associated with higher rates of incident AF and partially mediate the association between BMI and AF. In the same population, leptin and adiponectin levels are not significantly associated with AF.

Cited by 37 publications

References 30 publications

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta‐Analysis and Systematic Review

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta‐Analysis and Systematic Review

Are adipokines associated with atrial fibrillation in type 2 diabetes?

Obesity and atrial fibrillation: can adipokines help to solve this puzzle: Table 1

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