The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population

Sigit, Fathimah S.; Trompet, Stella; Tahapary, Dicky L.; Sartono, Erliyani; Dijk, Ko Willems van; Yazdanbakhsh, Maria; Supali, Taniawati; Smit, Johannes; Rosendaal, Frits R.; Mutsert, Renée de

doi:10.1016/j.numecd.2021.05.012

Cited by 7 publications

(5 citation statements)

References 53 publications

(34 reference statements)

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“…10 A similar association between hypoadiponectinemia and hyperleptinemia, and markers of adiposity and insulin resistance was also seen in a Dutch population. 20 The findings of this study, therefore, reinforce the strong association between markers of adiposity as well as other conventional risk factors for CMD and adiponectin and leptin. Conventional risk factors for CMD, such as obesity have been shown to be a much stronger determinant of serum adiponectin levels compared to serum leptin levels, 21 this could potentially explain why in this study, variations in serum adiponectin were fully explained by differences in conventional risk factors of CMD.…”

Section: Discussion Of Key Findingssupporting

confidence: 79%

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Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study

Kusi-Mensah,

Hayfron-Benjamin,

Chetty

et al. 2023

Clin Med Insights Endocrinol Diabetes

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Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent. Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders. Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians ( P < .001). In fully adjusted models, participants living in urban Ghana had significantly higher odds of hyperleptinemia compared to rural participants (women-odds ratio 2.88; 95% CI, 1.12-7.38, P = .028 and men 43.52, 95% CI, 4.84-391.25, P < .001). Urban Ghanaian men also had higher odds of elevated leptin: adiponectin ratio (6.29, 95% CI, 1.43-27.62, P = .015). The odds of hyperleptinemia were only higher in Amsterdam Ghanaian men (10.56; 95% CI, 1.11-100.85, P = .041), but not in women (0.85; 95% CI, 0.30-2.41, P = .759). There was no significant association between hypoadiponectinemia and geographical location in both sexes. Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans.

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Section: Discussion Of Key Findingssupporting

confidence: 79%

Section: Discussionsupporting

confidence: 79%

Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study

Kusi-Mensah,

Hayfron-Benjamin,

Chetty

et al. 2023

Clin Med Insights Endocrinol Diabetes

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“…Previous studies have shown that Asian populations have lower adiponectin concentrations than Caucasians ( 35 , 36 ). Moreover, adiponectin is correlated with MS in Chinese and Caucasian populations ( 12 , 13 ), but not in the Indonesian population ( 16 ). Additionally, the relationship between adiponectin and each MS component varies among participants of different races and sexes ( 12 , 29 ).…”

Section: Discussionmentioning

confidence: 91%

“…Previous cross-sectional studies have reported that hypoadiponectinemia is closely associated with MS and its components ( 12 , 13 ); however, a meta-analysis has indicated that increased adiponectin level is an independent protector against the development of MS, especially in men ( 14 ). Moreover, the relationship between adiponectin and MS varies with sex ( 15 ) and race ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Growth differentiation factor-15/adiponectin ratio as a potential biomarker for metabolic syndrome in Han Chinese

et al. 2023

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AimsGrowth differentiation factor-15 (GDF-15) and adiponectin are adipokines that regulate metabolism. This study aimed to evaluate the roles of GDF-15, adiponectin, and GDF-15/adiponectin ratio (G/A ratio) as biomarkers for detecting metabolic syndrome (MS).Materials and methodsThis cross-sectional study included 676 participants aged 20–70 years in Jurong, China. The participants were divided into four groups based on sex and age (<40 and ≥40 years). MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Receiver operating characteristic curves were used to evaluate the performance of GDF-15, adiponectin, and the G/A ratio in predicting MS.ResultsThe prevalence of MS was 22.0% (149/676). Logistic regression analysis indicated that the G/A ratio and adiponectin levels, but not GDF-15 levels, were correlated with MS [odds ratio; 95% CI 1.010 (1.006–1.013) and 0.798 (0.735–0.865), respectively] after adjusting for confounding factors. The G/A ratio displayed a significant relationship with MS in each subgroup and with each MS component in both men and women; however, adiponectin concentrations were significantly associated with MS and all its components only in men (all P <0.05). The area under the curve (AUC) of the G/A ratio and the adiponectin level for MS was 0.758 and 0.748, respectively. The highest AUC was 0.757 for the adiponectin level in men and 0.724 for the G/A ratio in women.ConclusionsThis study suggests that the G/A ratio and adiponectin are potential biomarkers for detecting MS in women and men, respectively.

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“…In Indonesia, the prevalence of the metabolic syndrome is 28 and 46% in men and women, respectively (Sigit et al. 2021 ). It has been proven that insulin resistance (IR) contributes to the pathophysiology of metabolic syndrome (Alwahsh et al.…”

Section: Introductionmentioning

confidence: 99%

Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model

Soetikno

Andini

Iskandar

et al. 2023

Pharmaceutical Biology

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Context α-Mangosteen (α-MG) attenuates insulin resistance (IR). However, it is still unknown whether α-MG could alleviate hepatic manifestations in IR rats. Objective To investigate the effect of α-MG on alleviating hepatic manifestations in IR rats through AMP-activated protein kinase (AMPK) and sterol-regulatory element-binding protein-1 (SREBP-1) pathway. Materials and methods IR was induced by exposing male Sprague-Dawley rats (180–200 g) to high-fat/high-glucose diet and low-dose injection of streptozotocin (HF/HG/STZ), then treated with α-MG at a dose of 100 or 200 mg/kg/day for 8 weeks. At the end of the study (11 weeks), serum and liver were harvested for biochemical analysis, and the activity of AMPK, SREBP-1c, acetyl-CoA carboxylase (ACC), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, insulin receptor substrate (IRS)-1, Bax and liver histopathology were analyzed. Results α-MG at both doses significantly lowered ALT, AST, triglyceride, and cholesterol total by 16.5, 15.7, 38, and 36%, respectively. These beneficial effects of α-MG are associated with the downregulation of the IR-induced inflammation in the liver. Furthermore, α-MG, at both doses, activated AMPK by 24–29 times and reduced SREBP-1c by 44–50% as well as ACC expression by 19–31% similar to metformin. All treatment groups showed liver histopathology improvement regarding fat deposition in the liver. Conclusions Based on the findings demonstrated, α-MG protected against HF/HG/STZ-induced hepatic manifestations of the IR rats, at least in part via the modulation of the AMPK/SREBP-1c/ACC pathway and it could be a potential drug candidate to prevent IR-induced hepatic manifestations.

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The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population

Cited by 7 publications

References 53 publications

Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study

Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study

Growth differentiation factor-15/adiponectin ratio as a potential biomarker for metabolic syndrome in Han Chinese

Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model

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