The associations of maternal and children’s gut microbiota with the development of atopic dermatitis for children aged 2 years

Abstract

BackgroundIt is critical to investigate the underlying pathophysiological mechanisms in the development of atopic dermatitis. The microbiota hypothesis suggested that the development of allergic diseases may be attributed to the gut microbiota of mother-offspring pairs. The purpose of this study was to investigate the relationship among maternal-offspring gut microbiota and the subsequent development of atopic dermatitis in infants and toddlers at 2 years old.MethodsA total of 36 maternal-offspring pairs were enrolled and followed up to 2 years postpartum in central China. Demographic information and stool samples were collected perinatally from pregnant mothers and again postpartum from their respective offspring at the following time intervals: time of birth, 6 months, 1 year and 2 years. Stool samples were sequenced with the 16S Illumina MiSeq platform. Logistic regression analysis was used to explore the differences in gut microbiota between the atopic dermatitis group and control group.ResultsOur results showed that mothers of infants and toddlers with atopic dermatitis had higher abundance of Candidatus_Stoquefichus and Pseudomonas in pregnancy and that infants and toddlers with atopic dermatitis had higher abundance of Eubacterium_xylanophilum_group at birth, Ruminococcus_gauvreauii_group at 1 year and UCG-002 at 2 years, and lower abundance of Gemella and Veillonella at 2 years. Additionally, the results demonstrated a lower abundance of Prevotella in mothers of infants and toddlers with atopic dermatitis compared to mothers of the control group, although no statistical difference was found in the subsequent analysis.ConclusionThe results of this study support that gut microbiota status among mother-offspring pairs appears to be associated with the pathophysiological development of pediatric atopic dermatitis.

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

“…In addition, offspring born to mothers with anxiety, depression, or stress had different gut microbiome diversity and bifidobacterial abundance 47 . Alteration in the gut microbiota may play a key role in the pathophysiological development of AD 48 . Furthermore, paternal stress can impact the health of offspring through genetic inheritance, particularly by altering the sperm epigenome.…”

“…47 Alteration in the gut microbiota may play a key role in the pathophysiological development of AD. 48 Furthermore, paternal stress can impact the health of offspring through genetic inheritance, particularly by altering the sperm epigenome. This includes modifications in DNA methylation, histone modifications, sncRNAs, and sncRNAsassociated alterations.…”

Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study

“…The gut microbiome can be seen as the primary filter mediating interactions with environmental factors, including dietary elements. Additionally, both the gut and skin microbiomes are influenced during natural childbirth and play a role in forming cutaneous/mucosal barriers in children [30]. Disruption of this delicate process could lead to the development of AD and a compromised resident immune system.…”

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

“…In addition, Fan et al studied 36 mother-offspring pairs. The results presented that mothers of infants and young children with AD had a higher abundance of Candida-tus_Stoquefichus and Pseudomonas during pregnancy and that children with AD had a higher abundance of Eubacterium_xylanophilum_group at birth, Ruminococcus_gauvreauii_group after 1 year of age, and UCG-002 after 2 years of age, and a lower abundance of Gemella and Veillonella after 2 years of age [71].…”