The associations of two novel inflammation indexes, systemic immune-inflammation index (SII) and system inflammation response index (SIRI), with periodontitis: evidence from NHANES 2009–2014

Luo, Shiyi; Liu, Zefei; Jiao, Ruofeng; Li, Wei; Sun, Jiangling; Ma, Su; Song, Jukun; Chen, Zhu

doi:10.1007/s00784-024-05529-1

Cited by 9 publications

(1 citation statement)

References 49 publications

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“…2 19 . Absence of periodontitis and mild in ammation were de ned as having no periodontitis, whereas moderate and severe in ammation were de ned as having periodontitis 20 . The Body Shape Index (ABSI) is an index used to assess the relationship between body shape and health risk, and was proposed by researchers at the City University of New York in 2012.…”

Section: Classi Cation Of Periodontitismentioning

confidence: 99%

Association between “A Body Shape Index” (ABSI) with periodontitis in a hypertension population from the NHANES 2009–2014

Gu,

Luo,

Sun

et al. 2024

Preprint

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Objective A body Shape index (ABSI), defined as waist circumference (WC)/ (body mass index (BMI) 2/3 × height 1/2), is unique in that the ABSI is positively associated with visceral obesity and is independent of BMI. The ABSI has also been shown to be positively and linearly correlated with the amount of visceral adiposity in the general population and with all-cause and cardiovascular disease (CVD). However, it is uncertain whether ABSI is associated with periodontitis in hypertensive patients. Methods A cross-sectional study of 2,482 hypertensive patients (mean age 65.2 ± 9.1 years) was conducted using the ABSI Z score, periodontitis as a dichotomous variable, the ABSI Z score as a continuous variable, and multiple covariates such as age, gender, and race. The data were analyzed using descriptive statistics, multiple logistic regression, subgroup analysis with EmpowerStats (version 4.2), and curve transformation plots were generated. Results In multivariate logistic regression analysis, ABSI Z score showed a significant positive association with periodontitis in the hypertensive population in all three models. When ABSI Z score was divided into low, medium, and high three groups, we observed that those with the highest ABSI Z score had a 20% increased risk of periodontitis among people with hypertension (OR = 1.2; 95%CI, 1.0-1.5, P = 0.046). We used smooth curve fitting to confirm the results and found that these results were still supported, and additional subgroup analyses showed that the positive association between ABSI Z score and periodontitis in hypertensive population was stable and consistent in the general population. Conclusion The present cross-sectional investigation showed a positive association between ABSI Z score and periodontitis in a hypertensive population.

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Section: Classi Cation Of Periodontitismentioning

confidence: 99%

Association between “A Body Shape Index” (ABSI) with periodontitis in a hypertension population from the NHANES 2009–2014

Gu,

Luo,

Sun

et al. 2024

Preprint

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Systemic immune‐inflammation states in US adults with seropositivity to infectious pathogens: A nutrient‐wide association study

Xie,

Halimulati,

Dou

et al. 2024

J Parenter Enteral Nutr

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BackgroundLimited understanding exists regarding the association between daily total dietary nutrient intakes and immune‐inflammation states in US adults exposed to various pathogens. This study sought to examine the correlation between nutrient intakes and immune‐inflammation indicators and to assess their performance in distinguishing immune‐inflammation states.MethodsThis study was derived from the National Health and Nutrition Examination Survey (NHANES), which included 33,804 participants aged 20 years or older between 2005 and 2018. Multivariable linear regression and restricted cubic spline regression were conducted to evaluate the association between nutrient intakes and immune‐inflammation indicators. Receiver operating characteristic curve analysis was performed to evaluate the discriminatory performance of identified nutrients for various immune‐inflammation states measured by the systemic immune‐inflammation index (SII).ResultsTen key nutrients were significantly associated with immune‐inflammation responses, including calcium, saturated fatty acid (SFA) 4:0, SFA 6:0, SFA 12:0, SFA 14:0, SFA 16:0, vitamin B2, total SFAs, retinol, and lutein + zeaxanthin, which show potential as dietary indicators. The area under the curve for discriminating various immune‐inflammation states was improved by at least 0.03 compared with a model that included only covariates, with all P values <0.05 in the Delong tests, indicating a significant enhancement in model performance.ConclusionsTen nutrients, including calcium, various SFAs, vitamin B2, retinol, and lutein + zeaxanthin, exhibit significant association with SII and potential as dietary indicators for distinguishing between different immune‐inflammation states in US adults with seropositivity to various viruses.

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U‐shaped association between pan‐immune‐inflammation value and periodontitis: NHANES 2009–2014

Zhou,

Zhang,

Miao

et al. 2024

Journal of Periodontology

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BackgroundThis study aimed to investigate the relationship between the pan‐immune‐inflammation value (PIV) and periodontitis based on a large national survey.MethodsIn the present cross‐sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.ResultsThe associations between PIV and stage III/IV periodontitis followed a U‐shaped pattern (Pnon‐linearity < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01–1.46), third quartile (OR = 1.34; 95% CI: 1.11–1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25–1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (ORQ4vs2 = 1.72, 95% CI: 1.36–2.18) and individuals with hypertension (ORQ4vs2 = 1.78, 95% CI: 1.38–2.28) with significant interactions (Pinteraction < 0.05).ConclusionsThere is a U‐shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.Plain Language SummaryA U‐shaped association exists between the pan‐immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.

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The associations of two novel inflammation indexes, systemic immune-inflammation index (SII) and system inflammation response index (SIRI), with periodontitis: evidence from NHANES 2009–2014

Cited by 9 publications

References 49 publications

Association between “A Body Shape Index” (ABSI) with periodontitis in a hypertension population from the NHANES 2009–2014

Association between “A Body Shape Index” (ABSI) with periodontitis in a hypertension population from the NHANES 2009–2014

Systemic immune‐inflammation states in US adults with seropositivity to infectious pathogens: A nutrient‐wide association study

U‐shaped association between pan‐immune‐inflammation value and periodontitis: NHANES 2009–2014

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