The astrocyte-enriched gene
            <i>deathstar</i>
            plays a crucial role in the development, locomotion, and lifespan of
            <i>D. melanogaster</i>

Zhang, Xiaoli; Sun, Dongyu; Wong, Kyle; Salkini, Ammar; Najafi, Hadi; Kim, Woo Jae

doi:10.1080/19336934.2024.2368336

Cited by 2 publications

(1 citation statement)

References 87 publications

(118 reference statements)

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“…For climbing assay, we modified the conventional RING assay (Gargano et al 2005) and reported in our previous reports (Miao et al 2024;Zhang et al 2024). In brief, 40-50 aged flies were placed in an empty vial and were tapped to the bottom of the tube.…”

Section: Climbing Assaymentioning

confidence: 99%

Hypersensitivity controlled by mir-9a modulates female receptivity ofDrosophila melanogaster

Zhang,

Bagley,

Huang

et al. 2024

Preprint

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Female Drosophila melanogaster undergo a complex behavioral transformation following mating, characterized by increased sensory sensitivity and altered reproductive behaviors. In this study, we investigated the role of miR-9a, a conserved microRNA, in regulating these post-mating changes. We found that miR-9a mutant females exhibited a hypersensitivity phenotype, with increased rejection of courting males, delayed onset of sexual receptivity, and abnormal mating termination behavior. This phenotype was associated with aberrant overgrowth of adult body wall sensory neurons, suggesting a link between neuronal hypersensitivity and reproductive behavior. To further elucidate the underlying mechanisms, we performed genetic interaction studies with sens and bru2, genes known to interact with miR-9a. We found that removing one copy of sens or bru2 in miR-9a mutant backgrounds rescued the female rejection phenotype and normalized neuronal morphology. This suggests that miR-9a regulates sensory neuron development and female receptivity by modulating the expression of target genes like sens and bru2. Our findings reveal a novel role for miR-9a in regulating sensory hypersensitivity and reproductive behaviors in Drosophila. This research provides valuable insights into the molecular mechanisms underlying post-mating behavioral adaptations and neural development. Additionally, our findings highlight the potential of Drosophila as a model organism for investigating the role of miR-9 family members in neuronal specification and function, with implications for understanding sensory processing and neural plasticity in other organisms.

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Section: Climbing Assaymentioning

confidence: 99%

Hypersensitivity controlled by mir-9a modulates female receptivity ofDrosophila melanogaster

Zhang,

Bagley,

Huang

et al. 2024

Preprint

Self Cite

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Male-specific sNPF peptidergic circuits control energy balance for mating duration through neuron-glia interactions

Zhang,

Miao,

Kang

et al. 2024

Preprint

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This study reveals a sexually dimorphic sNPF-sNPF-R circuit in the Drosophila brain that regulates energy balance behavior, specifically the shorter-mating-duration (SMD) response to sexual experience. sNPF is predominantly expressed in neurons, while sNPF-R is expressed in both neurons and glial cells, particularly astrocyte-like glia (ALG) in a subset of cells outside the mushroom body (MB) termed "Rishi cells" (RS cells). Sexual experience induces global alterations in calcium signaling and synaptic plasticity within this circuit, with sNPF-R expressing neurons and glia in RS cells playing a critical role in encoding sexual experience-related information into energy balance behavior related to mating duration. Neuronal glucose metabolism, specifically the Tret1l transporter, is essential for maintaining the high calcium levels and proper function of sNPF neurons near RS cells. This novel and intricate neuron-glia sNPF-sNPF-R network acts as critical circuits within the Drosophila brain for processing interval timing behaviors, highlighting the dynamic interplay between metabolism, neural circuits, and behavior in regulating energy balance.

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The astrocyte-enriched gene deathstar plays a crucial role in the development, locomotion, and lifespan of D. melanogaster

Cited by 2 publications

References 87 publications

Hypersensitivity controlled by mir-9a modulates female receptivity ofDrosophila melanogaster

Hypersensitivity controlled by mir-9a modulates female receptivity ofDrosophila melanogaster

Male-specific sNPF peptidergic circuits control energy balance for mating duration through neuron-glia interactions

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