The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision
Jiayin Gao,
Jiawei Wang,
Shiyu Liu
et al.
Abstract:The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for the first time, thus representing the beginning of developmental patterning. Here, we demonstrate that the molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, is asymmetrically expressed in the late 2-cell stage of mouse embryos. The knockdown ofHspa2in one of the two-cell blastomeres prevented its progeny predominantly toward the inner cell ma… Show more
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