The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population

Cai, Gaojun; Shi, Ganwei; Xue, Sheliang; Lü, Wei

doi:10.1097/md.0000000000008058

Cited by 240 publications

(237 citation statements)

References 22 publications

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“…These data indicated that IL-8 level is affected by intensity of exercise. The present study detected significant increase in atherogenic index in both obese non-ovx and obese ovx subgroup versus lean subgroup, these results also comes in agreement with other several studies, As Pourfarzam, et al [63] ; Zhan et al [64] ; Gaojun Cai et al [65] ; Shen et al [66] demonstrated that atherogenic index associated with metabolic syndrome and it was higher in coronary heart diseases. Furthermore it was positively correlated with TC, TG and negatively correlated with HDL-C.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

hamed¹,

Ahmed²,

Bedair³

et al. 2018

Zagazig University Medical Journal

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Background: Cardiovascular disease (CVD) is one of the leading causes of death worldwide and is more prevalent in post-menopausal women. Monocyte chemo-attractant protein-1(MCP-1) is a chemokine that attracts monocytes/macrophages to sites of inflammation and play a role in development of atherosclerosis. Objective: This study aimed to explore the effects of ovariectomy (Ovx) as a model of menopause on the serum level of MCP-1 in high fat diet induced atherogenesis and clarify the modulatory effects of moderate exercises on the serum level of MCP-1 in this model. Animals and methods: 96 female albino rats divided equally into 4 groups, each is subdivided equally into 2subgroups subgroup (Ia): non ovx ,sedentary, fed standard diet for 10 weeks, subgroup (Ib): non ovx ,sedentary, fed high fat diet for 10 weeks. Subgroup (IIa) ovx sedentary, fed standard diet for 10 weeks subgroup (IIb): ovx, sedentary fed high fat diet for 10 weeks. Subgroup (IIIa): non ovx ,exercised and fed standard diet for 10 weeks. subgroup (IIIb) non ovx ,exercised and fed high fat diet for 10 weeks. Subgroup (IVa): ovx ,exercised and fed standard diet for 10 weeks. subgroup (IVb) ovx ,exercised and fed high fat diet for 10 weeks. Results: in ovx obese sedentary rats, there was a significant (p <0.001) increase in MCP-1,Lipid profile, Atherogenic indices, Platelets activation percentage, Total leucocytic counts, Differential monocyte counts, and Interleukin 8 and aortic thickness versus lean subgroup. Swimming exercise showed significant (p <0.001) reductions in the above parameters, associated with significant increase in the serum HDL level in ovx obese exercised subgroup versus ovx obese sedentary subgroup. Conclusions: MCP-1 level increased in obesity and menopause leading to development of atherosclerosis and these changes could be reversed by adaptive moderate exercises.

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Section: Discussionsupporting

confidence: 93%

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

hamed¹,

Ahmed²,

Bedair³

et al. 2018

Zagazig University Medical Journal

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“…AIP was found to be higher in 2936 patients with coronary artery disease versus 2451 controls [25], while AIP has also been suggested as an independent risk factor for coronary artery disease [24,25]. An AIP value below 0.11 has been associated with low, values from 0.11 to 0.24 with intermediate, and values exceeding 0.24 with high cardiovascular disease risk [20][21][22]24,57]. Dobi a sov a et al examined 1433 subjects with various risks of atherosclerosis and reported that AIP directly correlated with the fractional esterification rate of HDL (r ¼ 0.803), and inversely correlated with LDL particle size (r = À0.776).…”

Section: Discussionmentioning

confidence: 94%

“…AIP reflects the lipoprotein composition in plasma, and it has been postulated as a surrogate marker for small dense LDL particles, and also as a predictor of atherosclerosis, cardiovascular risk, and even effectiveness of therapy [18][19][20][21]25,27]. AIP was found to be higher in 2936 patients with coronary artery disease versus 2451 controls [25], while AIP has also been suggested as an independent risk factor for coronary artery disease [24,25]. An AIP value below 0.11 has been associated with low, values from 0.11 to 0.24 with intermediate, and values exceeding 0.24 with high cardiovascular disease risk [20][21][22]24,57].…”

Section: Discussionmentioning

confidence: 99%

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Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects

et al. 2019

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Background and aims: Atherogenic index of plasma (AIP), defined as the logarithm of triglycerides to high-density lipoprotein cholesterol (HDL-C) ratio, is a strong predictor of future cardiovascular disease. Our aim was to examine the association of AIP with haemodynamic variables in normotensive and never-treated hypertensive subjects in a cross-sectional study. Methods: Supine haemodynamics in 615 subjects without antihypertensive and lipid-lowering medications were examined using whole-body impedance cardiography and radial pulse wave analysis. Linear regression analysis was applied to investigate the association of AIP with haemodynamic variables and age, sex, body mass index (BMI), smoking status, alcohol consumption, plasma C-reactive protein, electrolytes, uric acid, low density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate, and quantitative insulin sensitivity check index. Results: The demographics and laboratory values of the study population were (mean ± 95% confidence interval): age 44.9 ± 1.0 years, BMI 26.8 ± 0.4 kg/m 2 , office blood pressure 140.6 ± 1.6/ 89.4 ± 1.0 mmHg, total cholesterol 5.2 ± 0.08, LDL-C 3.1 ± 0.08, triglycerides 1.2 ± 0.08, HDL-C 1.6 ± 0.04 mmol/l, and AIP À0.15 ± 0.02. Age (standardized coefficient Beta 0.508, p < .001) and aortic systolic blood pressure (Beta 0.239, p < .001) presented with the strongest associations with pulse wave velocity. However, AIP was also associated with pulse wave velocity (Beta 0.145, p < .001). AIP was not related with aortic or radial blood pressure, cardiac output, systemic vascular resistance, or augmentation index. Conclusions: AIP is directly and independently associated with arterial stiffness, a variable strongly related to cardiovascular risk. This supports more widespread use of AIP in standard clinical cardiovascular disease risk evaluation. ARTICLE HISTORY

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“…The TC/HDL-C and TG/HDL-C molar ratios are associated with coronary heart disease (24). Furthermore, the atherogenic index is used as a predictor of atherosclerosis and coronary artery disease (25,26). The increase in cholesterol is associated with the risk of fatty liver and atherosclerosis (5).…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Kim

Cho²,

Jang³

2018

Int J Mol Med

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Diospyros (D.) lotus has been demonstrated to have antioxidant and anti-inflammatory properties. The purpose of the present study was to evaluate the effect of D. lotus leaf water extract (DLE) on high-fat diet (HFD)-induced obesity in c57BL/6 mice. The present study first investigated the effect of DLE on the lipid accumulation and triglyceride (TG) contents in 3T3-L1 cells, and the results revealed that treatment with DLE suppressed the lipid accumulation and TG level. Subsequently, the anti-obesity effects of DLE were investigated in vivo. Oral administration of DLE reduced the body weight gain, food efficiency ratio, and liver and visceral fat weight in mice fed with a HFD. DLE administration in these mice also reduced TG, total cholesterol, low-density lipoprotein cholesterol, glucose, insulin and leptin levels, as well as the atherogenic index. Furthermore, DLE administration decreased hepatic steatosis, as well as serum aspartate transaminase, alanine transaminase and alkaline phosphatase levels in mice fed with HFD. It was further observed that treatment of the HFD-fed mice with DLE prevented lipid peroxidation, while it recovered glutathione depletion and the activities of superoxide dismutase, catalase and glutathione peroxidase. In conclusion, the current study suggests that the anti-obesity effect of DLE may provide positive insights as a potential functional food ingredient for the prevention of obesity.

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The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population

Cited by 240 publications

References 22 publications

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

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