OBJECTIVES: A study of the dental, periodontal, oral mucosal and salivary condition of adult patients with chronic renal failure (CRF) receiving hemodialysis (HD). MATERIAL AND METHODS: A total of 105 patients on HD were studied, together with 53 healthy age and sexmatched controls. Indices employed included carious, absent and obturated teeth index (CAO index), plaque index, calculus index and loss of periodontal attachment. Whole and parotid salivary secretions were also measured. RESULTS: The CAO index was not significantly higher among HD patients than controls (14.9 ؎ 8.7 vs 13.3 ؎ 7.9, respectively; t ؍ 1.1; P ؍ 0.3). However, plaque and calculus indices were significantly higher in HD patients (2.1 ؎ 0.8 and 2.3 ؎ 0.6, respectively) than controls (1.3 ؎ 0.8 and 1.6 ؎ 0.9) (P Ͻ 0.001). Loss of periodontal attachment was similar in both groups (4.9 ؎ 2.5 vs 4.2 ؎ 2.5 in the HD patients and controls, respectively) (t ؍ 1.8; P ؍ 0.07). There was no more oral mucosal pathology in HD patients than in controls (chi-square ؍ 5.8; P ؍ 0.3). Stimulated salivary secretion was significantly higher in controls than HD patients for both whole (t ؍ ؊5.2; P Ͻ 0.001) and parotid (t ؍ ؊2.6; P ؍ 0.01) salivas. CONCLUSIONS: The results show significantly higher plaque and calculus indices and lower salivary secretion among the HD patients than in healthy controls.