The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila

González-Morales, Nicanor; Géminard, Charles; Lebreton, Gaëlle; Cerezo, Delphine; Coutelis, Jean-Baptiste; Noselli, Stéphane

doi:10.1016/j.devcel.2015.04.026

Cited by 64 publications

(87 citation statements)

References 79 publications

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“…The handedness determined by Myo31DF in the H1 segment might be conveyed to the H2 segment through atypical cadherins, Dachsous and Fat. Schema is adopted from González-Morales et al [24]. …”

Section: Cell Chirality and Hindgut Laterality In Drosophilamentioning

confidence: 99%

Cell chirality: its origin and roles in left–right asymmetric development

Inaki

Liu

Matsuno

2016

Phil. Trans. R. Soc. B

154

147

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An item is chiral if it cannot be superimposed on its mirror image. Most biological molecules are chiral. The homochirality of amino acids ensures that proteins are chiral, which is essential for their functions. Chirality also occurs at the whole-cell level, which was first studied mostly in ciliates, single-celled protozoans. Ciliates show chirality in their cortical structures, which is not determined by genetics, but by ‘cortical inheritance’. These studies suggested that molecular chirality directs whole-cell chirality. Intriguingly, chirality in cellular structures and functions is also found in metazoans. In Drosophila, intrinsic cell chirality is observed in various left–right (LR) asymmetric tissues, and appears to be responsible for their LR asymmetric morphogenesis. In other invertebrates, such as snails and Caenorhabditis elegans, blastomere chirality is responsible for subsequent LR asymmetric development. Various cultured cells of vertebrates also show intrinsic chirality in their cellular behaviours and intracellular structural dynamics. Thus, cell chirality may be a general property of eukaryotic cells. In Drosophila, cell chirality drives the LR asymmetric development of individual organs, without establishing the LR axis of the whole embryo. Considering that organ-intrinsic LR asymmetry is also reported in vertebrates, this mechanism may contribute to LR asymmetric development across phyla.This article is part of the themed issue ‘Provocative questions in left–right asymmetry’.

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Section: Cell Chirality and Hindgut Laterality In Drosophilamentioning

confidence: 99%

Cell chirality: its origin and roles in left–right asymmetric development

Inaki

Liu

Matsuno

2016

Phil. Trans. R. Soc. B

154

147

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“…The rotation itself seems to mediate actin bundling and only becomes dispensable after the basement membrane is polarized [221]. This process also requires the atypical cadherin Fat [220], which is also involved in L/R symmetry breaking in other organs of D. melanogaster (see above, [214]). Interestingly, rotational motion of mammary epithelial acini in 3D environments also leads to extracellular matrix deposition and lack of rotation leads to a loss of matric deposition [222].…”

Section: Melanogastermentioning

confidence: 99%

“…Notably, individual cellular chirality is integrated into planar polarity in the case of hindgut morphogenesis and thereby leads to asymmetric organ patterning [199]. Here, the atypical cadherin Dachous and the Dachsous/Fat/Frizzled planar cell polarity pathway (see below) are involved in transducing intracellular information [214]. This pathway is known to be responsible for cytoskeletal organization and junctional remodeling [215].…”

Section: Melanogastermentioning

confidence: 99%

Cytoskeletal Symmetry Breaking and Chirality: From Reconstituted Systems to Animal Development

Pohl

2015

Symmetry

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Animal development relies on repeated symmetry breaking, e.g., during axial specification, gastrulation, nervous system lateralization, lumen formation, or organ coiling. It is crucial that asymmetry increases during these processes, since this will generate higher morphological and functional specialization. On one hand, cue-dependent symmetry breaking is used during these processes which is the consequence of developmental signaling. On the other hand, cells isolated from developing animals also undergo symmetry breaking in the absence of signaling cues. These spontaneously arising asymmetries are not well understood. However, an ever growing body of evidence suggests that these asymmetries can originate from spontaneous symmetry breaking and self-organization of molecular assemblies into polarized entities on mesoscopic scales. Recent discoveries will be highlighted and it will be discussed how actomyosin and microtubule networks serve as common biomechanical systems with inherent abilities to drive spontaneous symmetry breaking.

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“…Nanos is present in stem cells involved in regeneration in planarians [30]. Finally, Piwi also functions in maintaining both germline and somatic stem cells in Drosophila [31].…”

Section: Functionmentioning

confidence: 99%

Germ Cell Specification: The Evolution of a Recipe to Make Germ Cells

Krishnakumar¹,

Dosch²

2018

Germ Cell

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Multicellular species use gametes for their propagation. Gametes are formed from primordial germ cells (PGCs), which develop during embryogenesis. In some species, PGCs are speciied by the inheritance of a RNA granule known as germ plasm. During germ cell speciication, the germ plasm conveys a unique set of properties, e.g. the germ cell speciic meiotic cell cycle to the PGCs. Germ plasm assembly is controlled by independently evolving organizer proteins like Oskar in Drosophila or Bucky ball in zebraish. These organizers are intrinsically disordered proteins, which rapidly changed their amino acid sequence during evolution. A common recipe has emerged by studies on organizer proteins for animals that use germ plasm to specify their germline. Investigating the nature of these organizers might therefore provide a clue to germ cell speciication in other species, which are less accessible to molecular-genetic and embryological approaches. Moreover, we might understand how the irst metazoans modiied their existing cellular structures from unicellular eukaryotes to ensure their reproduction.

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The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila

Cited by 64 publications

References 79 publications

Cell chirality: its origin and roles in left–right asymmetric development

Cell chirality: its origin and roles in left–right asymmetric development

Cytoskeletal Symmetry Breaking and Chirality: From Reconstituted Systems to Animal Development

Germ Cell Specification: The Evolution of a Recipe to Make Germ Cells

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