The atypical E2F transcription factor DEL1 modulates growth–defense tradeoffs of host plants during root-knot nematode infection

Nakagami, Satoru; Saeki, Kentaro; Toda, Kei; Ishida, Takashi; Sawa, Shinichiro

doi:10.1038/s41598-020-65733-3

Cited by 12 publications

(8 citation statements)

References 35 publications

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“…The del1-1 mutant showed SA accumulation in 7 dpi Arabidopsis galls, while in uninfected roots, the SA levels did not change significantly compared to the control background Col-0. Therefore, DEL1 seems to repress SA biosynthesis in RKNs-induced galls in Arabidopsis ( Nakagami et al., 2020 ; Table 1 ; Figure 2 ). As a result, del1-1 mutant galls at 5 dpi exhibited more intense lignin staining than wild type galls, and the expression patterns of genes encoding enzymes related to lignin biosynthesis, such as 4-coumarate: CoA ligase 1 (4CL1), 4CL2, alcohol dehydrogenase 5 (CAD5), phenylalanine ammonia-lyase 1 (PAL1), PAL2, and cinnamate 4-hydroxylase (C4H) were significantly up-regulated as compared to wild type galls ( Nakagami et al., 2020 ).…”

Section: Plant Transcription Factors Relevant During Rkns Infection W...mentioning

confidence: 99%

“…Therefore, DEL1 seems to repress SA biosynthesis in RKNs-induced galls in Arabidopsis ( Nakagami et al., 2020 ; Table 1 ; Figure 2 ). As a result, del1-1 mutant galls at 5 dpi exhibited more intense lignin staining than wild type galls, and the expression patterns of genes encoding enzymes related to lignin biosynthesis, such as 4-coumarate: CoA ligase 1 (4CL1), 4CL2, alcohol dehydrogenase 5 (CAD5), phenylalanine ammonia-lyase 1 (PAL1), PAL2, and cinnamate 4-hydroxylase (C4H) were significantly up-regulated as compared to wild type galls ( Nakagami et al., 2020 ). The loss of function of DEL1/E2Fe in Arabidopsis galls leads to enhanced resistance and it also causes growth inhibition, likely due to excessive lignification and/or SA accumulation in RKNs-induced galls.…”

Section: Plant Transcription Factors Relevant During Rkns Infection W...mentioning

confidence: 99%

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Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction

Domínguez-Figueroa,

Gómez-Rojas,

Escobar

2024

Front. Plant Sci.

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Root-knot nematodes are polyphagous parasitic nematodes that cause severe losses in the agriculture worldwide. They enter the root in the elongation zone and subtly migrate to the root meristem where they reach the vascular cylinder and establish a feeding site called gall. Inside the galls they induce a group of transfer cells that serve to nurture them along their parasitic stage, the giant cells. Galls and giant cells develop through a process of post-embryogenic organogenesis that involves manipulating different genetic regulatory networks within the cells, some of them through hijacking some molecular transducers of established plant developmental processes, such as lateral root formation or root regeneration. Galls/giant cells formation involves different mechanisms orchestrated by the nematode´s effectors that generate diverse plant responses in different plant tissues, some of them include sophisticated mechanisms to overcome plant defenses. Yet, the plant-nematode interaction is normally accompanied to dramatic transcriptomic changes within the galls and giant cells. It is therefore expected a key regulatory role of plant-transcription factors, coordinating both, the new organogenesis process induced by the RKNs and the plant response against the nematode. Knowing the role of plant-transcription factors participating in this process becomes essential for a clear understanding of the plant-RKNs interaction and provides an opportunity for the future development and design of directed control strategies. In this review, we present the existing knowledge of the TFs with a functional role in the plant-RKN interaction through a comprehensive analysis of current scientific literature and available transcriptomic data.

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Section: Plant Transcription Factors Relevant During Rkns Infection W...mentioning

confidence: 99%

Section: Plant Transcription Factors Relevant During Rkns Infection W...mentioning

confidence: 99%

Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction

Domínguez-Figueroa,

Gómez-Rojas,

Escobar

2024

Front. Plant Sci.

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“…SA accumulation leads to the activation of plant defense responses. Nakagami et al. (2020) showed that DEL1 represses excessive SA accumulation and root growth inhibition of host plants upon RKN infection in Arabidopsis .…”

Section: Genetic and Molecular Basis Of Tradeoff To Developing Breeding Populations And Cultivarsmentioning

confidence: 99%

Mitigating tradeoffs in plant breeding

Dwivedi¹,

Reynolds

Ortíz

2021

iScience

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Summary Tradeoffs among plant traits help maintain relative fitness under unpredictable conditions and maximize reproductive success. However, modifying tradeoffs is a breeding challenge since many genes of minor effect are involved. The intensive crosstalk and fine-tuning between growth and defense responsive phytohormones via transcription factors optimizes growth, reproduction, and stress tolerance. There are regulating genes in grain crops that deploy diverse functions to overcome tradeoffs, e.g., miR-156- IPA1 regulates crosstalk between growth and defense to achieve high disease resistance and yield, while OsALDH2B1 loss of function causes imbalance among defense, growth, and reproduction in rice. GNI-A1 regulates seed number and weight in wheat by suppressing distal florets and altering assimilate distribution of proximal seeds in spikelets. Knocking out ABA-induced transcription repressors (AITRs) enhances abiotic stress adaptation without fitness cost in Arabidopsis . Deploying AITRs homologs in grain crops may facilitate breeding. This knowledge suggests overcoming tradeoffs through breeding may expose new ones.

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“…Gall formation efficiency was evaluated as reported (Nakagami et al 2020). In brief, Gall number and germinated seedlings number were counted for each petri dish of six seedlings.…”

Section: Evaluation Of Gall Formation Efficiencymentioning

confidence: 99%

Identification of genes involved in <i>Meloidogyne incognita</i>-induced gall formation processes in <i>Arabidopsis thaliana</i>

Suzuki

Ueda

Wada

et al. 2021

Plant Biotechnology

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Root-knot nematodes (RKN; Meloidogyne incognita) are phytoparasitic nematodes that cause significant damage to crop plants worldwide. Recent studies have revealed that RKNs disrupt various physiological processes in host plant cells to induce gall formation. However, little is known about the molecular mechanisms of gall formation induced by nematodes. We have previously found that RNA expression levels of some of genes related to micro-RNA, cell division, membrane traffic, vascular formation, and meristem maintenance system were modified by nematode infection. Here we evaluated these genes importance during nematode infection by using Arabidopsis mutants and/or β-glucronidase (GUS) marker genes, particularly after inoculation with nematodes, to identify the genes involved in successful nematode infection. Our results provide new insights not only for the basic biology of plant-nematode interactions but also to improve nematode control in an agricultural setting.

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The atypical E2F transcription factor DEL1 modulates growth–defense tradeoffs of host plants during root-knot nematode infection

Cited by 12 publications

References 35 publications

Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction

Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction

Mitigating tradeoffs in plant breeding

Identification of genes involved in <i>Meloidogyne incognita</i>-induced gall formation processes in <i>Arabidopsis thaliana</i>

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