The Auditory Nerve Overlapped Waveform (ANOW) Originates in the Cochlear Apex

Lichtenhan, Jeffery T.; Hartsock, JJ; Gill, RM; Guinan, John J.; Salt, Alec N.

doi:10.1007/s10162-014-0447-y

Cited by 48 publications

(68 citation statements)

References 38 publications

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“…The first is that the literature suggests that a significant proportion of the RW response is generated from auditory nerve potentials in addition to OHCs, especially for low-frequency stimuli (Henry, 1995; Patuzzi et al, 1989; He et al, 2012; Lichtenhan et al, 2014). In order to quantify the proportion of neural and OHC potentials present in the RW response, or cochlear response (CR), Chertoff et al (2014) damaged the auditory nerve with 10 mM of an ototoxic drug, ouabain, and recorded the CR before and after an acute application to the RW niche.…”

Section: Introductionmentioning

confidence: 99%

The potential use of low-frequency tones to locate regions of outer hair cell loss

et al. 2016

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Current methods used to diagnose cochlear hearing loss are limited in their ability to determine the location and extent of anatomical damage to various cochlear structures. In previous experiments, we have used the electrical potential recorded at the round window –the cochlear response (CR) –to predict the location of damage to outer hair cells in the gerbil. In a follow-up experiment, we applied 10 mM ouabain to the round window niche to reduce neural activity in order to quantify the neural contribution to the CR. We concluded that a significant proportion of the CR to a 762 Hz tone originated from phase-locking activity of basal auditory nerve fibers, which could have contaminated our conclusions regarding outer hair cell health. However, at such high concentrations, ouabain may have also affected the responses from outer hair cells, exaggerating the effect we attributed to the auditory nerve. In this study, we lowered the concentration of ouabain to 1 mM and determined the physiologic effects on outer hair cells using distortion-product otoacoustic emissions. As well as quantifying the effects of 1 mM ouabain on the auditory nerve and outer hair cells, we attempted to reduce the neural contribution to the CR by using near-infrasonic stimulus frequencies of 45 and 85 Hz, and hypothesized that these low-frequency stimuli would generate a cumulative amplitude function (CAF) that could reflect damage to hair cells in the apex more accurately than the 762 stimuli. One hour after application of 1 mM ouabain, CR amplitudes significantly increased, but remained unchanged in the presence of high-pass filtered noise conditions, suggesting that basal auditory nerve fibers have a limited contribution to the CR at such low frequencies.

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Section: Introductionmentioning

confidence: 99%

The potential use of low-frequency tones to locate regions of outer hair cell loss

et al. 2016

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“…If basilar membrane displacement to a low frequency tone is not everywhere constant and in phase along the cochlear spiral, electrical responses of differing polarity from many cells will sum and consequently smooth the amplitude of the cochlear response. Moreover, slow biasing of cochlear mechanics with a low-frequency tone has largely ignored the contribution of neural excitation that is predominately phase locked to low-frequency tones (Henry, 1995;He et al, 2012;Lichtenhan et al, 2014;Stankovic and Guinan, 1999). That is to say, low frequency tones evoke both hair cell and neural responses.…”

Section: Introductionmentioning

confidence: 99%

An analysis of cochlear response harmonics: Contribution of neural excitation

Chertoff

Kamerer

Peppi

et al. 2015

The Journal of the Acoustical Society of America

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In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f Tr ). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f Tr . From gerbil ears, estimates of f Tr were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f Tr before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f Tr but not the sigmoidal, saturating, nonlinear morphology.

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“…Current findings support that when appropriately analyzed, CEOAEs can yield information about multiple sites along the basilar membrane, and may be beneficial in terms of test duration. The more precise estimation of spectral components at low frequencies via the ST is important, and is potentially beneficial because of the growing interests to gain a better understanding of the apical cochlear mechanics (e.g., Dhar et al, 2011;Lichtenhan et al, 2014;Temchin and Ruggero, 2010).…”

Section: Discussionmentioning

confidence: 99%