The AURKA Gene rs2273535 Polymorphism Contributes to Breast Carcinoma Risk - Meta-analysis of Eleven Studies

Guo, Xu‐Guang; Feng, Weibo; Xia, Yong

doi:10.7314/apjcp.2014.15.16.6709

Cited by 11 publications

(14 citation statements)

References 28 publications

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“…Our results showed that subjects with Phe/Ile genotype or at least one Phe allele had a significant reduced risk to breast cancer in Malaysian Chinese women even after Bonferroni correction, suggesting that it can be act as a strong protective biomarker for breast cancer in the population. This finding was similar to recent meta-analysis studies claiming that the Ile allele was an increase risk factor for breast cancer (Qin et al, 2013;Tang et al, 2013;Dai et al, 2014;Guo et al, 2014;Xu et al, 2014;Qin et al, 2015). In Malaysia, Malaysian Chinese women has the highest breast cancer incidences when compared to other ethnic groups (Leong et al, 2007;Pathy et al, 2011), and it is yet to clarify that the role of genetic abnormality contribute to the high incidence rate in this ethnic.…”

Section: 647 Association Of Cyp2e1 Stk15 and Xrcc1 Polymorphisms Wisupporting

confidence: 86%

“…Taken together, there is significant evidence showing that these three genes are involve in modulating the pathway in the development of breast cancer. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) were inconclusively associated to breast cancer risk in case-control or meta-analysis studies in different populations (Wu et al, 2006;Bu et al, 2014;Dai et al, 2014;Ding et al, 2014;Feng et al, 2014;Guo et al, 2014;Qin et al, 2015), but association of these SNPs to breast cancer in Southeast Asia populations, especially in Malaysian women was unquestionably insufficient. Therefore, this pilot study investigates the association of these SNPs, together with etiology factors such as age and ethnicity, to breast cancer risk in Malaysian women.…”

Section: Introductionmentioning

confidence: 99%

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Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

Chong

Goh²,

See³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is the most common type of cancer affecting Malaysian women. Recent statistics revealed that the cumulative probability of breast cancer and related deaths in Malaysia is higher than in most of the countries of Southeast Asia. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) have been associated with breast cancer risk in a meta-analysis but any link in Southeast Asia, including Malaysia, remained to be determined. Hence, we investigated the relationship between these SNPs and breast cancer risk among Malaysian women in the present case-control study. Materials and Methods: Genomic DNA was isolated from peripheral blood of 71 breast cancer patients and 260 healthy controls and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. No significance association was found between XRCC1 SNPs and breast cancer risk in the population. Conclusions: This study provides additional knowledge on CYP2E1, STK15 and XRCC1 SNP impact of risk of breast cancer, particularly in the Malaysian population. From our findings, we also recommend Malaysian women to perform breast cancer screening before 50 years of age.Keywords: Breast cancer -CYP2E1 -Malaysian women -single nucleotide polymorphisms -STK15 -XRCC1

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Section: 647 Association Of Cyp2e1 Stk15 and Xrcc1 Polymorphisms Wisupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

Chong

Goh²,

See³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…The risk of breast cancer is high in individuals with the AURKA rs2273535 polymorphism 38 , while the AURKA 91A (rs2273535) polymorphism is associated with a high risk of oral cancer 39 . In Caucasians, the AURKA rs1047972 polymorphism is associated with a decreased risk of breast cancer 40 .…”

Section: Discussionmentioning

confidence: 99%

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma

Wang¹,

Hsu²,

Chou³

et al. 2018

Int. J. Med. Sci.

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Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at AURKA SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the AURKA gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC.

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“…A previous study demonstrated that the AURKA 91A (rs2273535) allele polymorphism is associated with a high risk of oral cancer [ 21 ]. Previous studies have also suggested that the AURKA rs2273535 polymorphism is associated with a high risk of breast cancer, particularly in Asians [ 31 ]. However, the AURKA rs1047972 polymorphism has been shown to reduce the incidence of breast cancer in Caucasians [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan

Chou

Chuang

et al. 2017

PLoS ONE

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BackgroundOral squamous cell carcinoma (OSCC) is the sixth and fourth most common cause of cancer death in men worldwide and in Taiwan, respectively. AURKA, which encodes a centrosome-related serine/threonine kinase, is frequently amplified and overexpressed in many human cancers, particularly advanced OSCC. We conducted a hospital-based case-control study to estimate AURKA single-nucleotide polymorphisms (SNPs) and environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics.Methodology/Principal findingsWe enrolled a total of 876 OSCC patients and 1200 controls. Four SNPs of AURKA, namely rs1047972, rs2273535, rs2064863, and rs6024836, were analyzed using real-time polymerase chain reaction (PCR). Among the 1420 smokers, the AURKA polymorphism carriers with the betel nut chewing habit had a higher risk of oral cancer than AURKA wild-type (WT) carriers without the betel nut chewing habit. Patients with the AURKA rs2064863 gene had a 1.365-fold higher risk of stage III or IV OSCC (95% confidence interval [CI] 1.029–1.811) than those with the rs2064863 WT gene. Furthermore, carriers of the AURKA rs1047972/rs2273535/rs2064863 C-A-T haplotype had a 1.736-fold (95% CI 1.110–2.715) higher risk of OSCC than controls (C-T-T, the most common haplotype). Among patients with the betel quid chewing habit, carriers of other haplotypes (C-T-T, C-A-G, T-A-T, T-A-G, T-T-T, and C-T-G) had a 12.857-fold (95% CI 10.731–15.404) increased risk, and carriers of the C-A-T haplotype had the highest risk (AOR: 31.120; 95% CI 13.864–69.850) of OSCC, compared with those without the betel quid chewing who harbored other haplotypes.ConclusionsIn conclusion, betel nut chewing combined with the AURKA C-A-T haplotypes lead to a high risk of OSCC. These findings reveal a novel genetic-environmental predisposition for oral tumorigenesis.

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The AURKA Gene rs2273535 Polymorphism Contributes to Breast Carcinoma Risk - Meta-analysis of Eleven Studies

Cited by 11 publications

References 28 publications

Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma

Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan

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