2024
DOI: 10.1101/2024.03.22.586303
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The AusAB non-ribosomal peptide synthase inStaphylococcus aureuspreferentially incorporates exogenous phenylalanine and tyrosine into the aureusimine natural products

Adriana Moldovan,
Markus Krischke,
Claudia Huber
et al.

Abstract: Non-ribosomal peptide synthases (NRPS) are modular multidomain enzymes, responsible for the biosynthesis of various secondary metabolites, in a mRNA-template independent manner. They are predominantly present in bacteria and fungi, where they synthesize a variety of products, including antibiotics, siderophores, toxins and signalling molecules. The human pathogen Staphylococcus aureus possesses one single NRPS, AusA, highly conserved in all sequenced S. aureus strains. AusA incorporates the aromatic amino acid… Show more

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