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Soh, Avril Z; Chee, C. B. E.; Wang, Yee‐Tang; Yuan, Jian‐Min; Koh, Woon‐Puay

doi:10.1093/aje/kwx383

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…As one of three major beverages (Peng et al, 2016;Yu et al, 2020), tea (Camellia sinensis) is closely related to the lifestyles and dietary habits of people in many countries (Roy et al, 2008;Soh et al, 2017;Tsuboi et al, 2019;Inoue-Choi et al, 2022). Fuzhuan brick tea (FBT), as a Chinese traditional tea, belongs to dark tea with a unique fermentation process.…”

Section: Introductionmentioning

confidence: 99%

Exploration of the hypoglycemic mechanism of Fuzhuan brick tea based on integrating global metabolomics and network pharmacology analysis

Xiang,

You,

Zeng

et al. 2024

Front. Mol. Biosci.

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Introduction: Fuzhuan brick tea (FBT) is a worldwide popular beverage which has the appreciable potential in regulating glycometabolism. However, the reports on the hypoglycemic mechanism of FBT remain limited.Methods: In this study, the hypoglycemic effect of FBT was evaluated in a pharmacological experiment based on Kunming mice. Global metabolomics and network pharmacology were combined to discover the potential target metabolites and genes. In addition, the real-time quantitative polymerase chain reaction (RT-qPCR) analysis was performed for verification.Results: Seven potential target metabolites and six potential target genes were screened using the integrated approach. After RT-qPCR analysis, it was found that the mRNA expression of VEGFA, KDR, MAPK14, and PPARA showed significant differences between normal and diabetes mellitus mice, with a retracement after FBT treatment.Conclusion: These results indicated that the hypoglycemic effect of FBT was associated with its anti-inflammatory activities and regulation of lipid metabolism disorders. The exploration of the hypoglycemic mechanism of FBT would be meaningful for its further application and development.

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